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The role of caveolae in stretch- vs. flow-induced vascular responses was investigated using caveolin-1 deficient (KO) mice. Portal veins were stretched longitudinally for 5 min (acute) or 72 h (organ culture). Basal ERK1/2 and Akt phosphorylation were increased in organ-cultured KO veins, as were protein synthesis and vessel wall cross-section. Stretch stimulated acute phosphorylation of ERK1/2 an
C3 nephritic factors are autoantibodies that prolong the half-life or prevent regulation of the alternative pathway C3 convertase, resulting in uncontrolled complement activation. They are strongly associated with renal disease but their role in pathogenesis remains controversial. Here we optimized and compared a panel of assays to identify and interrogate nephritic factor activities. Of 101 patie
Here, we present the activities within our research group over the last five yearswith cantilevers fabricated in the polymer SU-8. We believe that SU-8 is an interestingpolymer for fabrication of cantilevers for bio/chemical sensing due to its simple processingand low Young’s modulus. We show examples of different integrated read-out methodsand their characterisation. We also show that SU-8 cantil
Popular Abstract in Swedish Fibromodulin och dystrofin i ateroskleros; en populärvetenskaplig sammanfattning VAD ÄR ATEROSKLEROS? Ateroskleros – det man tidigare kallade för åderförkalkning – är grundorsaken till hjärtinfarkt, stroke och kärlkramp. Ett aterosklerosplack är en förträngning i ett blodkärl, ofta vid en förgrening där blodflödet är turbulent. Placket börjar ofta växa redan i unga år Cardiovascular disease represents nearly half the cases of noncommunicable diseases worldwide and is the leading global cause of death. The main underlying cause is atherosclerosis, and in atherosclerotic plaque progression the structure, composition and integrity of a dynamic extracellular matrix (ECM) is one very important factor. This thesis discusses the importance of the connection between th
The goal of this master thesis is to set up a low cost automated robotic test system which can later be reproduced to greatly increase test coverage. Mostly through experimental research this thesis will find good components to use and evaluate these from a performance and cost perspective. It will also develop computer vision algorithms needed and automation software for the final set up. The per
Med ofta stora summor involverade i ärenden relaterade till osäkra hamnar är det av stort intresse för både redaren och befraktaren att etablera deras respektive risk de har under en resa. Den här uppsatsen behandlar relationen mellan redaren och befraktaren då redaren har åsamkats skada på grund av en osäker hamn. Frågan är till vilken grad det är möjligt att hålla befraktaren ansvarig för en såWith often large amounts involved, the issue of unsafe ports is of great interest for both the shipowner and the charterer in order to establish what kind of risk they would bear under a voyage. This thesis deals with the relationship between the shipowner and the charterer when the shipowner has suffered a loss due to an unsafe port. The question is to what extent it is possible to hold the char
This thesis explores the interlinking of evaluation and development through an anthropological lens by considering the indigenization process of an evaluation culture, and how evaluation travels across boundaries as an assemblage, similar to many other global phenomena. Central to the thesis is the national evaluation capacity building trend viewed as a two-sided project; first as internal capacit
The aim of this master thesis has been to develop a Blocking device that makes sure that a Spring parking brake is not unintentionally activated after a manual release. There is also a need for developing a new Piston indicator that should give two signals depending on if the Spring parking brake is active or inactive. Both are supposed to fit with a completely new generation of Spring parking bra
Biodiesel is an important alternative to ordinary diesel when limiting the effects on the climate. However, the production path of biodiesel produces a wastewater with a high chemical oxygen demand (COD) and it needs to be cleaned. The aim of this study was to characterise biodiesel wastewater as well as to suggest treatment options. The biodiesel wastewater studied came from a biodiesel plant i
The increasing prevalence of antimicrobial-resistant bacterial infections has ushered in a major global public health crisis. Judicious or restricted antimicrobial use in animal agriculture, aiming to confine the use for the treatment of infections, is the most commonly proposed solution to reduce selection pressure for resistant bacterial strains and resistance genes. However, a multifaceted solu
Purpose: Boys with genetic syndromes have an increased risk of undescended testes (UDT), but laparoscopic findings and outcomes after two-stage Fowler-Stephens orchiopexy (FS2) are rarely reported. This study aims to compare laparoscopic findings and results after FS2 between syndromic and non-syndromic boys. Methods: A retrospective cohort study on boys with UDT who underwent laparoscopy between
Urban freight systems play an indispensable role in contemporary cities. By enabling the continuous flow of goods, they support economic activity and contribute to urban prosperity. At the same time, these activities generate substantial negative externalities, including emissions, noise, congestion and increasing pressures on urban space. As freight activities grow, their impacts intensify, under
Motivation Machine learning offers a powerful approach for building predictive models from high-dimensional molecular data. Omics technologies such as transcriptomics, proteomics, and metabolomics quantify thousands of molecules simultaneously, providing deep insights into disease biology. Integrating multiple modalities can enhance predictive performance, as shown in histology-omics and holter-om
Jerome of Stridon was one of the most important biblical exegetes in early Christianity. Analyzing letters as well as prefaces to biblical commentaries written by Jerome, this article discusses four criteria which he considered to be necessary for orthodox exegesis to take place: 1) education and learning; 2) studying the Scriptures as part of an ascetic lifestyle; 3) divine help; and 4) learning
Integrating multi-modal patient data to support personalized medicine has gained a lot of interest across different health domains over the past decade. Addressing this challenge requires the development and implementation of an informed, evidence-based AI-driven decision-support system continuously maintained and updated to align with the latest clinical guidelines. A key challenge to ensure its
Implant-associated infections (IAIs) are one of the leading concerns in orthopedics and dentistry as they commonly lead to implant failure. The presence of biofilms and, increasingly frequently, drug-resistant bacteria further impairs the efficacy of conventional antibiotics. Immobilization of antimicrobial peptides (AMPs) on implant surfaces is a promising alternative to antibiotics for preventio
The objective of this thesis is to investigate the feasibility of constructing temporary warehouse halls using glulam (glued laminated timber) frames, as well as to explore alternative solutions to PVC fabric for roofing and walls. The background is an increasing demand for temporary and flexible ware- house structures across several industries, along with a growing interest in environmentally fr
We live in an increasingly individualistic society where involuntary loneliness, especially among older adults, has become a growing issue. In Sweden, where single-person households are common, many seniors, particularly those over 65 who live alone, report feeling lonely. At the same time, children are growing up with limited contact with older generations, as everyday interactions between age gr
