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Ecologists are now widely utilising video data to quantify the behaviours and interactions of animals in the wild. This process can be facilitated by collecting videos in stereo, which can provide information about animals' positions, movements and behaviours in three-dimensions (3D). However, there are no published designs that can collect underwater 3D stereo data at high spatial and temporal re
It is universally acknowledged that highly photosensitive transistors are strongly dependent on the high carrier mobility of polymer-based semiconductors. However, the polymer π–π stacking and aggregation, required to increase the charge mobility, conversely inhibit the dissociation of photogenerated charge carriers, in turn accelerating the geminate recombination of electron-hole pairs. To explor
OBJECTIVE: Salt-inducible kinase 2 (SIK2) is abundantly expressed in adipocytes and downregulated in adipose tissue from individuals with obesity or insulin resistance. The main aims of this work were to investigate the involvement of SIKs in the regulation of glucose uptake in primary mature human adipocytes and to identify mechanisms underlying this regulation.METHODS: Primary mature adipocytes
Energy efficiency in buildings remains an important priority for the European Union. Towards that direction, therole of the one-stop-shops (OSSs) that will offer integrated renovation services has been further enhanced. Thepaper aims to compare public and private-driven OSSs to increase knowledge regarding the way they operate.The business models of ten OSSs for renovation of residential buildings
Background: Cognitive impairment is common following out-of-hospital cardiac arrest (OHCA), but the nature of the impairment is poorly understood. Our objective was to describe cognitive impairment in OHCA survivors, with the hypothesis that OHCA survivors would perform significantly worse on neuropsychological tests of cognition than controls with acute myocardial infarction (MI). Another aim was
INTRODUCTION: Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale. METHOD: One thousand forty-five participants underwent tau scans with either 18F-flortaucipir, 18F-MK6240, 18F-PI2
The incorporation of machine learning methods into proteomics workflows improves the identification of disease-relevant biomarkers and biological pathways. However, machine learning models, such as deep neural networks, typically suffer from lack of interpretability. Here, we present a deep learning approach to combine biological pathway analysis and biomarker identification to increase the interp
Glucagon-like peptide-1 (GLP-1) receptor agonists are established pharmaceutical therapies for the treatment of type 2 diabetes and obesity. They mimic the action of GLP-1 to reduce glucose levels through stimulation of insulin secretion and inhibition of glucagon secretion. They also reduce body weight by inducing satiety through central actions. The GLP-1 receptor agonists used clinically are ba
Baserat på fullständiga sammanställningar av subskriptionerne på 2 Timoteusbrevet i 485 grekiska manuskript, presenterar denna studie texttraditionen och utvecklingen av dessa subskriptioner och förklarar deras förhållande till andra subskriptioner, paratexter, de interna material i 1–2 Timoteus, Apostlagärningarna och det bredare. kyrkohistoria. Studien spårar källan/källorna bakom traditionen atBased on full collations of the subscriptions to 2 Timothy in 485 Greek manuscripts, this study presents the textual tradition and development of these subscriptions and explains their relationship to other subscriptions, paratexts, the internal evidence in 1–2 Timothy, Acts, and the wider church history. The study tracks the source(s) behind the tradition that the letter was sent to Timothy, inst
Sharing is considered as one of the key elements in circular economy, as well as away to deliver social impact. According to the New Bauhaus initiative by the EuropeanCommission, new neighbourhoods should be environmentally sustainable, provide anaesthetic experience, and deliver social inclusion. This study explores the emergence of sharing business models in the real estate industry. The aim is
To better understand the genetics of hearing loss, we performed a genome-wide association meta-analysis with 125,749 cases and 469,497 controls across five cohorts. We identified 53/c loci affecting hearing loss risk, including common coding variants in COL9A3 and TMPRSS3. Through exome sequencing of 108,415 cases and 329,581 controls, we observed rare coding associations with 11 Mendelian hearing
Sedimentary molybdenum (Mo) and uranium (U) enrichments are widely used to reconstruct changes in bottom water oxygen conditions in aquatic environments. Until now, most studies using Mo and U have focused on restricted suboxic-euxinic basins and continental margin oxygen minimum zones (OMZs), leaving mildly reducing and oxic (but eutrophic) coastal depositional environments vastly understudied. C
Background: Newborn infants affected by hypoxic-ischemic encephalopathy (HIE) undergo therapeutic hypothermia. As this treatment seems to be associated with pain, and intensive and invasive care is needed, pharmacological interventions are often used. Moreover, painful procedures in the newborn period can affect pain responses later in life, impair brain development, and possibly have a long-term
Climate change is already affecting crop production, and in some cases is undermining the viability of current crop systems.Crop research and development plays a critical role in developing the technologies and practices farmers need to maximize productivity and manage the increasing risks they face. This paper investigates how transformative adaptation - long-term, systemic change to fundamental
Leadership is as an integral part of organisational practice that relates to individual or collectivistic forms of decision-making and action that include strategic decision-making, such as how issues are communicated or ‘framed’, and how risk is managed. This article applies a systematic scoping review approach to understand the scope of scholarly literature on human rights leadership and assess
Background: Urosepsis is a life-threatening condition that needs to be addressed without delay. Two critical issues in its management are: (1) Appropriate empirical antibiotic therapy, considering the patients general condition, comorbidity, and the pathogen expected; and (2) Timing of imaging to identify obstruction requiring decompression. Objectives: To identify risk factors associated with 30-
