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Background Riks-Stroke, the Swedish Stroke Register, is the world's longest-running national stroke quality register (established in 1994) and includes all 76 hospitals in Sweden admitting acute stroke patients. The development and maintenance of this sustainable national register is described. Methods Riks-Stroke includes information on the quality of care during the acute phase, rehabilitation a
Objective Histological evaluation of intestinal biopsies for the diagnosis of coeliac disease can be challenging and compatible with risk of misdiagnosis. The aim was to evaluate the agreement of pathological diagnosis for coeliac disease in children investigated at four major paediatric university hospitals in Sweden. Materials and methods Intestinal duodenal biopsies were collected from 402 chil
The difficulties of demonstrating that any specific form of psychotherapy is more effective than any other has led to the formulation of the so-called Dodo Bird Verdict (that all forms of therapy are equally effective) and to the suggestion that what really matters for therapeutic efficiency are factors that are common to different forms of therapy. The term “common factors”, however, is seldom de
Hypothesis: Sodium dioctylsulfosuccinate (Aerosol OT or NaAOT) is a well-studied charging agent for model poly(methyl methacrylate) (PMMA) latexes dispersed in nonpolar alkane solvents. Despite this,few controlled variations have been made to the molecular structure. A series of counterion exchanged analogs of NaAOT with other alkali metals (lithium, potassium, rubidium, and cesium) were prepared,
In National Audit Offices (NAOs), impact is often used as a measure of success, serving to build legitimacy. When aiming to maximize impact, the media tends to play an important role. Based on empirical observations from the Swedish NAO, this paper explores how the role of the media for a NAO can be understood, and how this may affect independence. It is suggested that impact can be understood ei
Popular Abstract in Swedish Den största källan till läkemedelsrester i vattenmiljön är utgående renat avloppsvatten från våra kommunala reningsverk. Läkemedel är utvecklade för att ha olika typer av biologiska effekter. Vilka dessa är i människan är relativt välkänt, medan effekterna på vattenlevande organismer och andra djur till stor del är okända. Detta i kombination med deras resistens mot de The discharge of effluents from wastewater treatment plants (WWTPs) is considered to be the major source of residual pharmaceuticals frequently found in aquatic environments. The complex nature of such compounds tends to make conventional biological treatments aimed at their removal ineffective. The present thesis concerns the removal of 62 different active pharmaceutical ingredients commonly dete
The model for permanent deformation in asphalt concrete (AC) layers used in the Mechanistic-Empirical Pavement Design Guide (MEPDG) was evaluated. Two instrumented flexible pavements were subjected to heavy vehicle simulator testing at three constant temperatures. Permanent deformation modelling was carried out using the MEPDG software v1.003 at the highest accuracy level. The nationally calibrate
Modelling the sedimentation of suspensions with partial differential equations requires constitutive relations (material properties) to be known. Restricted to suspensions obeying Kynch's assumption (ideal suspensions), this paper deals with the inverse problem, which is to estimate the batch-settling flux function from experimental data. A new batch-settling test is suggested, from which it is th
The Environmental Determinants of Diabetes in the Young (TEDDY) is an international study aiming to investigate associations between dietary and other environmental factors and the risk of developing islet autoimmunity and type 1 diabetes. Dietary intake was assessed using a 24-h recall and repeated 3-day food records and analyzed using country-specific food composition databases (FCDBs) in Finlan
β-1,4-Galactosyltransferase 7 (β4GalT7) is a key enzyme in the biosynthesis of glycosaminoglycan (GAG) chains. Natural and synthetic xylosides can be used to both inhibit and prime GAG synthesis by acting as inhibitors or substrates for β4GalT7. In this report, we exploit hydroxylated oxanes as deoxygenated xyloside analogs to clarify the minimum protein-ligand interactions required for galactosyl
We overexpressed and purified enzymes involved in the pyrimidine catabolic pathway in the yeast Saccharomyces (Lachancea) kluyveri. A new vector was therefore designed, providing the first specific expression system in Saccharomyces kluyveri. The URC1 gene was overexpressed and a soluble protein obtained and successfully purified using the C-terminally added His-tag. Our system will be used for fu
