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Symptoms of infection and tissue pathology are caused by the host response; not by the microbe per se. The same response is also critical for the defence and is needed to clear infection. It is therefore essential to understand how the host response is activated and to identify the critical effector mechanisms of the defence. We have studied these issues in the urinary tract infection (UTI) model.
To evaluate the cost-effectiveness of an additional 12-week treatment with varenicline for abstainers who had successfully completed an initial 12-week treatment. The Benefits of Smoking Cessation on Outcomes simulation model was used to simulate both direct and indirect effects of smoking cessation. All calculations were performed in 2003 Swedish prices. Sweden in 2003. The modelled cohort consis
Recently, we showed that 10.2% of consecutively patch-tested hand eczema patients had a positive patch test to a selection of fragrances containing fragrances relevant to hand exposure. In this study, we used repeated skin exposure to a patch test-positive fragrance allergen in patients previously diagnosed with hand eczema to explore whether immersion of fingers in a solution with or without the
To describe the Avodart after Radical Therapy for prostate cancer Study (ARTS), investigating the use of dutasteride (a dual 5 alpha-reductase inhibitor that suppresses intraprostatic dihydrotestosterone, reduces tumour volume and improves other markers of tumour regression in prostate cancer) to prevent or delay disease progression in patients with biochemical recurrence after therapy with curati
I identify what I see as three aspects of contemorary cosmopolitan philosophy: A certain moral consciousness, a commitment to moral universalism, and an institutional implication of the first two. The third of these is often regarded as a fall-out or consequence of the other two. I argue instead that the institutional aspect should be regarded as primary and that a distinctive feature of cosmopoli
Our main result gives necessary and sufficient conditions, in terms of Fourier transforms, for an ideal in the algebra L-1(G parallel to K, omega), the convolution algebra of zonal functions on the automorphism group on the unit disc which are integrable with respect to the weight; function omega, to be dense in the algebra, or to have as closure an ideal of functions whose set of common zeros of
Objective: The aim of this study was the validation of the criteria defining a significant mucocutaneous-bleeding history in type 1 von Willebrand disease (VWD). Subjects and methods: To avoid selection bias, 42 obligatory carriers (OC) of type 1 VWD were identified from a panel of 42 families with type 1 VWD enrolled by 10 expert centers. OC were identified by the presence of an offspring and ano
Erosional outliers are an important component of the Ludlow (Late Silurian) stratigraphy of Gotland, Sweden. However, due to the poor degree of exposure, outcrop studies have not revealed a detailed section from any of these outliers. The first complete stratigraphy of such an erosional remnant. the Burgen outlier, is presented here, based on the recently recovered Burgen-1 drillcore. Stratigraphi
In this study, we investigated the interaction of fengycin, a lipopeptide produced by Bacillus subtilis, with lipid monolayers using the Langmuir trough technique in combination with Brewster angle rnicroscopy. Thermodynamic analyses were performed to get further information about the mixing behavior and the molecular interactions between the two components. The effect of fengycin on the structura
Retrograde and transganglionic labeling techniques are commonly used to visualize subsets of neurons and sensory afferent projections in the nervous system. These methods commonly require anesthesia and surgical methods. However, some tracers can also be administered systemically in awake animals, thus reducing risks associated with anesthesia and surgery and allowing for labeling of neuronal popu
Purpose: To evaluate against Monte-Carlo the performance of various dose calculations algorithms regarding lung turnout coverage in stereotactic body radiotherapy (SBRT) conditions. Materials and methods: Dose distributions in virtual lung phantoms have been calculated using four commercial Treatment Planning System (TPS) algorithms and one Monte Carlo (MC) system (EGSnrc). We compared the perform
Abstract is not available
In this contribution, we reflect on the particular function of international criminal law to prevent refugee crises of the type that provided a major trigger for the debate on military and legal interventionism in the 1990s. Based on the dichotomy of formal and substantive justice, we analyze the achievements of International Criminal Tribunals and look into the Gotovina judgment in particular. We
