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Mutational signatures are patterns of mutations that arise during tumorigenesis. We present an enhanced, practical framework for mutational signature analyses. Applying these methods to 3,107 whole-genome-sequenced (WGS) primary cancers of 21 organs reveals known signatures and nine previously undescribed rearrangement signatures. We highlight interorgan variability of signatures and present a way
Importance Perforated colonic diverticulitis usually requires surgical resection, with significant morbidity. Short-term results from randomized clinical trials have indicated that laparoscopic lavage is a feasible alternative to resection. However, it appears that no long-term results are available. Objective To compare long-term (5-year) outcomes of laparoscopic peritoneal lavage and primary
Artificial intelligence (AI) algorithms for automated classification of skin diseases are available to the con-sumer market. Studies of their diagnostic accuracy are rare. We assessed the diagnostic accuracy of an open-access AI application (Skin Image Search™) for recognition of skin diseases. Clinical images including tumours, infective and inflammatory skin diseases were collected at the Depart
The hexagonal swedenborgite, CaBaCo2Fe2O7, is a chiral frustrated antiferromagnet, in which magnetic ions form alternating kagome and triangular layers. We observe a long-range 3×3 antiferromagnetic order setting in below TN=160 K by neutron diffraction on single crystals of CaBaCo2Fe2O7. Both magnetization and polarized neutron single crystal diffraction measurements show that close to TN spins l
The present study explored presence of meaning in life, search for meaning in life, and their correlation with health anxiety. The Meaning in Life Questionnaire and the Short Health Anxiety Inventory were completed by 753 individuals. Results indicated higher presence of meaning in life was associated with lower health anxiety, while the opposite was observed for search for meaning in life. Result
Doses to the eyes of interventional radiologists and cardiologists could exceed the annual limit of 20 mSv proposed by the International Commission on Radiological Protection. Lead glasses of various designs are available to provide protection, but standard eye dosemeters will not take account of the protection they provide. The aim of this study has been to derive dose reduction factors (DRFs) eq
Glass is largely used in architectural and engineering applications (i.e., buildings and vehicles) as a structural material, especially in the form of laminated glass (LG) sections. To achieve adequate and controlled safety levels in these applications, the well-known temperature-dependent behavior of viscoelastic interlayers for LG sections should be properly accounted for during the design proce
A search for exotic decays of the Higgs boson into a pair of spin-zero particles, H → aa, where the a-boson decay sin to b-quarks promptly or with a mean proper lifetime cτa up to 6 mm and has a mass in the range of 20–60 GeV, is presented. The search is performed in events where the Higgs boson is produced in association with a W or Z boson, giving rise to a signature of one or two charged lepton
An approach for large scale protein identification and quantification was described. The peptide mixtures from the strong cation exchange (SCX) fractionated protein digests were separated and analyzed by HPLC MS/MS. The human fibrobalst nuclei were purified from stimulated and non-stimulated cells. The quantification results with MALDI and ESI LC/MS were shown to be identical within experimental e
Integrated Assessment and Modelling (IAM) provides an interdisciplinary approach to support ex-ante decision-making by combining quantitative models representing different systems and scales into a framework for integrated assessment. Scenarios in IAM are developed in the interaction between scientists and stakeholders to explore possible pathways of future development. As IAM typically combines m
With the rapid development of blood biomarkers (BBMs) related to amyloid-β (Aβ) pathology in Alzheimer's disease (AD), the question arises whether these can replace the accepted reference standard, positron emission tomography (PET), for assessing Aβ burden. BBMs can differentiate Aβ status reliably in cognitively impaired patients, but two-threshold strategies to further improve their performance
An investigation concerning a group of paintings sharing a common motif. The motif is the Madonna with the infants Jesus and Saint John, the Infant Jesus holding a goldfinch. Rapahel's version of the painting, in the Uffizi, is discussed in relation to a similar version of the motif that appeared in Sweden in the 1990's.
In a recent paper we presented a procedure for optimal analyticalcontrol of several deformable mirrors based on only the measured guidestar wavefronts. The expected performance was evaluated for variousguide star configurations using up to three deformable mirrors. Forsimplicity the guide stars were assumed to be infinitely distant. Inthis paper we address the effect of using laser guide stars in
Teacher shortages and occupational strain have increased interest in understanding the factors that support long-term teacher sustainability. Drawing on the Job Demands-Resources (JD-R) model and the Sustainable Working Life for All Ages (SwAge) framework, this study examined how organizational demands and resources relate to teacher professional sustainability in Hungary and Sweden. Professional
This thesis examines the market access barriers faced by small-scale producers in Bolivia, with a focus on Chiquitania, Los Valles Cruceños, and Zongo. Drawing on 15 semi-structured interviews with producers, vendors, university staff, and institutional actors, it analyses how structural, institutional, and relational barriers shape not only producers’ ability to reach markets, but also their abil
Popular Abstract in Swedish Kolhydrater är viktiga inte bara som bränsle och strukturgivande egenskaper, vilket var uppfattningen för 25 år sedan. De ingår även som en mycket viktig del i hur celler kommunicerar med varandra. Det har de senaste åren visat sig vara kolhydrater inblandade i en mängd signalering- och igenkänningsmekanismer. Några exempel: när bakterier angriper en cell är det oftast Artificial, amfiphilic, and biomimetic receptors soluble in water were synthesized via attaching polar amino acids to hydrophobic back-bones possessing a surface suitable for hydrophobic interactions. The hydrophobic back-bones chosen in this thesis were anthracene and dibenzobarrelene structures. A route to an efficient synthesis of a dibenzobarrelene backbone with two sets of orthogonal reactivi
Borderline Personality Disorder (BPD) has largely been associated with self-harm and chronic suicidality, despite the fact that these behaviours comprise only one diagnostic criterion. Treatments for self-harm are mostly indicated for individuals with BPD. Emerging literature suggests that youth with histories of depression are at risk of both self-harm and completed suicide. For individuals with
