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Context: Robot-assisted laparoscopic radical prostatectomy (RALP) using the da Vinci Surgical System (Intuitive Surgical, Sunnyvale, CA, USA) is now in widespread use for the management of localised prostate cancer (PCa). Many reports of the safety and efficacy of this procedure have been published. However, there are few specific reports of the limitations and complications of RALP. Objective: Th

Although Rac and its activator Tiam1 are known to stimulate cell-cell adhesion, the mechanisms regulating their activity in cell-cell junction formation are poorly understood. Here, we identify beta 2-syntrophin as a Tiam1 interactor required for optimal cell-cell adhesion. We show that during tight-junction (TJ) assembly beta 2-syntrophin promotes Tiam1-Rac activity, in contrast to the function o

BACKGROUND: With the increasing number of breast cancer (BC) diagnosed as a second primary malignancy after a first primary non-breast cancer (BCa-2), it is unclear about the familial risk of BC among women with a first-degree relative (FDR, parents or siblings) affected by a BCa-2.METHODS: In this Swedish nationwide cohort study, 5315 women with a FDR affected by BCa-2 and 115,048 women with a FD

SPINK1+/ETS- prostate cancer is an aggressive disease with poor clinical outcome. New data suggest a novel treatment by upregulating the expression of miR-338-5p/-421 through epigenetic modulation or by miRNA replacement. This is a new and interesting concept that warrants further exploration in clinical trials.See related article by Bhatia et al., p. 2755.

Syfte: Syftet med denna uppsats är att bidra till klarhet av och förståelse för vilken eller vilka aktörer som påverkar FASB i deras beslutsprocess vid införandet av en ny eller vid förändringen av en befintlig redovisningsstandard. Metod: Denna uppsats är en dokumentstudie av deskriptiv karaktär. En deduktiv ansats har legat till grund för att uppnå uppsatsens syfte. Urvalstekniken är ett så kall

This report has resulted in a method to evaluate and map the safety culture within a company. The method consists of two templates. One template, the assessment template, which works as a reference point and one presentation template where simply the facts and status of the company will be presented and evaluated compared to the assessment template. Safety culture relates to attitudes, behaviour,

Today hazard studies are a self evident part of a project plan while creating a new process or making changes in an existing one in the chemical industry. Therefore it is important to make the hazard studies as efficient as possible. The objective for this thesis was to optimise the hazard study processes based on the main methods presently used at Neste Oil Oyj, Neste Jacobs Oy and Borealis Polym

Vårt syfte är att beskriva och analysera hur benchmarkinganvänds i svenska detaljhandelskedjor med inriktning mot mode. Syftet är även att behandla fallföretagens erfarenheter av benchmarkingarbetet och ta reda på om det finns potential hos styrverktyget som inte utnyttjas. Vi har utfört en kvalitativ fallstudie, med en deduktiv ansats av fyra detaljhandelskedjor. Vår teoretiska teferensram består

Hållbar utveckling är idag ett centralt begrepp och en vision inom alla tänkbara samhällsområden. Det utgör kärnan i svensk planeringslagstiftning. Såväl kommunalt översiktsplanearbete som regionalt utvecklingsarbete har tydliga perspektiv för en hållbar utveckling. Sveriges samhällsorganisation kan karaktäriseras av ett timglas med en stark stat, starka kommuner och en svag regional nivå i mitten

This thesis examines how the transition from a linear product development process to a faster and iterative one affects the extent and quality of cross-functional collaboration within a company. It investigates both what changes such a transition entails, as well as how they may be explained. The setting of the study is the software development department of a multinational consumer electronics fi

The title, “for she loved much”, stems from Luke 7:47. The aim of this essay is to interpret Luke 7:36-50 using the method of narrative criticism, since the structure and rhythm of the episode is similar to the structure of a novel. The purpose is to inquire into the issues of forgiveness by analyzing whether the sinful woman of the city was forgiven before or after approaching Jesus during the di

Background/introduction: Scania supply chain is responsible for packaging to protect parts during transportation from their suppliers around the world. For many years Scania has used returnable packaging for inbound logistics of automotive parts. Scania packaging can be divided into two groups; namely Standard packaging and Special packaging. Problem description: When introducing a newer solution

Syftet med denna uppsats är att undersöka om de teoretiska fördelarna som Machine Learning kan ha på kapabiliteten hos AI-robotar har fått genomslag, och hur dessa fördelar kommer att påverka hur RPA-robotar placeras i verksamhetsprocesser i form av roll och uppgift. Genom intervjuer med branschexperter och sammanställning av teorier ser vi att introduceringen av ML i RPA-robotar kan innebära en u

This thesis proposes an autoregressive credit spread model to make long term simulations of credit spreads and credit indices in the Investment grade and High yield bond segments. Several models are tested, and the final spread model produces simulations with statistics consistent with historical data, even though the model itself is relatively parsimonious. A transition from spread to index is pro