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A method for identifying cascading effects in past events as an input to a decision support tool

Increasing interdependencies between critical infrastructures have made these systems more effective, but also more susceptible to cascading failures. In order to reduce the likelihood and consequences of cascading failures, it is essential to develop tools that support incident commander decisions so that an initial failure does not spread to other infrastructures. Here, a framework for generatin

The effect of including societal consequences for decisions on critical infrastructure vulnerability reductions

Critical infrastructures provide society with services that are essential for its functioning and extensive disruptions of these give rise to large societal consequences. Vulnerability analysis gives important decision information concerning improving their ability to withstand strains. To analyze vulnerabilities in infrastructures models for estimating consequences due to failures are needed. Con

The Primacy of Right. On the Triad of Liberty, Equality and Virtue in Wollstonecraft's Political Thought

I argue along the following lines: For Wollstonecraft, liberty is independence in two different spheres, one presupposing the other. On the one hand, liberty is independence in relation to others, in the sense of not being vulnerable to their whim or arbitrary will. Call this social, or political, liberty. For liberty understood in this way, infringements do not require individual instances of int

Power-driven FPGA to ASIC conversion

Gate arrays are often presented as a convenient means for ASIC prototyping. Obviously, they can both perform the same function and therefore be built from the same behavioral description. Design development implies a process of subsequent parameter bindings, leaving steadily less freedom for the remaining implementation choices. On the other hand, the ASIC offers more place & route freedom tha

Determinants for local tumour control probability after radiotherapy of anal cancer

Background and purpose: Anal squamous cell carcinoma is primarily treated with radiotherapy (RT), but the optimal RT dose for anal tumours of different sizes is not known. The purpose of this study was to identify determinants for local tumour control probability (LTCP). Material and methods: From a large Nordic database 901 patients who received RT for anal cancer between 2000 and 2007 were selec

Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

Cancer-associated fibroblasts (CAFs) are a major constituent of the tumor microenvironment, although their origin and roles in shaping disease initiation, progression and treatment response remain unclear due to significant heterogeneity. Here, following a negative selection strategy combined with single-cell RNA sequencing of 768 transcriptomes of mesenchymal cells from a genetically engineered m

Pulsar Binaries as Gravitational-Wave Sources: Rate predictions

Pulsar binaries are important targets for ground-based and future space-borne gravitational-wave (GW) detectors. In order for improving detector design and assessing detector performances, it is a prerequisite to understand the astrophysics of GW sources such as the population size or merger rates. Here, we summarize recent results for Galactic merger rates of two known types of pulsar binaries: (

Societal consequences of critical infrastructure vulnerabilities: integrating power system and regional inoperability input-output models

Critical infrastructures provide indispensable services to society and extensive disruption of these give rise to large societal consequences. Most risk-related studies of critical infrastructures, however, focus rather narrowly on the direct consequences, e.g. expressed by services not supplied or cost of nonsupplied services. Although these measures might serve as a proxy for the direct societal

The Ups and Downs of the Holocene: Exploring Relationships between Global CO2 and Climate Variability in the North Atlantic Region

This thesis aimed to examine the relationship between climate and atmospheric CO2 concentrations through rapid climate changes during the Holocene. Climate was reconstructed using high-resolution, radiocarbon dated, lake sediment geochemical proxies (magnetic susceptibility, loss-on-ignition, total carbon/nitrogen/sulphur determinations and biogenic silica), vegetational reconstruction (pollen ana

Environmental value orientation as an explanation of differing motives for conservation of the local biodiversity.

Biological diversity encompasses the genetic diversity within each species, the range of species in a given ecosystem e.g. species diversity and the diversity of ecosystems across an entire region (Primack, 2000). At present 1 per cent of the world’s described species are threatened with extinction. The most pervasive and overriding threat is habitat loss and degradation due to human activity such

Ingrid Bergman as Wartime Mediator : Swedish Immigrants as “the Same” in the OWI-film Swedes in America

The short film Swedes in America from 1943, produced by the Office of War Information, is constructed to show in which ways Sweden and the United States should be regarded as two nations nearly identical regarding social and human values. Up until this point, Swedes had in American cinema been portrayed as “the Other” but were now, in the American Second World War propaganda machinery, transformed

Contrasting vulnerability reduction measures for critical infrastructures: using power system and regional inoperability input-output models

Critical infrastructures provide society with services that are essential for its functioning and extensive disruptions of these give rise to large societal consequences. Vulnerability analysis gives important decision information concerning improving their ability to withstand strains. To analyze vulnerabilities in infrastructures models for estimating consequences due to failures are needed. Con