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Deoxyribonucleoside kinases are feedback inhibited by the final products of the salvage pathway, the deoxyribonucleoside triphosphates. In the present study, the mechanism of feedback inhibition is presented based on the crystal structure of a complex between the fruit fly deoxyribonucleoside kinase and its feedback inhibitor deoxythymidine triphosphate. The inhibitor was found to be bound as a bi
Sulphur-containing analogues of d-glucose were tested for effects on insulin release, d-glucose transport and d-glucose oxidation in microdissected pancreatic islets of obese-hyperglycemic mice. Substituting sulphur for oxygen in the ring structure of d-glucose (5-thio-d-glucose) resulted in a total loss of insulin-releasing ability. 5-Thio-d-glucose inhibited d-glucose-stimulated insulin release,
Intersectional MAIHDA involves applying multilevel models in order to estimate intercategorical inequalities. The approach has been validated thus far using both simulations and empirical applications, and has numerous methodological and theoretical advantages over single-level approaches, including parsimony and reliability for analyzing high-dimensional interactions. In this issue of SSM, Lizott
This Letter presents direct searches for lepton flavour violation in Higgs boson decays, H→eτ and H→μτ, performed with the ATLAS detector at the LHC. The searches are based on a data sample of proton–proton collisions at a centre-of-mass energy s=13 TeV, corresponding to an integrated luminosity of 36.1 fb−1. No significant excess is observed above the expected background from Standard Model proce
What are the pedagogical impacts of internationalisation on the development of higher education in Europe? How can we proceed in this process and take a pedagogical stance on the issue? This theoretical article is partly based on a series of empirical studies, conducted by the author, investigating students' and teachers' experiences and understanding of an internationalised educational context in
The highly eroded 23 km diameter Rochechouart impact structure, France, has extensive evidence for post-impact hydrothermal alteration and sulphide mineralisation. The sulphides can be divided into four types on the basis of their mineralogy and host rock. They range from pyrites and chalcopyrite in the underlying coherent crystalline basement to pyrites hosted in the impactites. Sulphur isotopic
It would appear that all possible types of source material concerning pre-colonial and colonial Indian history had been found and analyzed only to be reanalyzed repeatedly, resulting in a number of macro-level studies. However, micro-level studies have been very rare. This may be so because many a historian of India believed that sources necessary for such studies did not exist as there was no tra
Aim Identify injury-related, patient-reported and treatment-related prognostic factors for 5-year outcomes in acutely ACL-ruptured individuals managed with early reconstruction plus exercise therapy, exercise therapy plus delayed reconstruction or exercise therapy alone. Methods Exploratory analysis of the Knee Anterior Cruciate Ligament, Nonsurgical versus Surgical Treatment (KANON) trial (ISRCTN
This study presents a 2-yr follow-up of 281 patients, aged 15-34 yr, diagnosed with diabetes between 1992 and 1993. At diagnosis, 224 (80%) patients were positive for at least one of the following autoantibodies: islet cell antibodies (ICAs), glutamic acid decarboxylase antibodies (GADAs), or tyrosine phosphatase antibodies (IA-2As); the remaining 57 (20%) patients were negative for all three auto
In Case C-364/13 International Stem Cell Corporation (ISCC) v. Comptroller General of Patents (December 18th, 2014), the Court of Justice of the European Union (CJEU) distinguished its’ earlier ruling in Brüstle v. Greenpeace (Brüstle) with regard to non-fertilized human ova stimulated by parthenogenesis. The Court found that in order to be considered a ‘human embryo’- and thus to be unpatentable
8000 years ago, prior to Neolithic agriculture, Europe was mostly a wooded continent. Since then, its forest cover has been progressively fragmented, so that today it covers less than half of Europe's land area, in many cases having been cleared to make way for fields and pasture-land. Establishing the origin of Europe's current, more open land-cover mosaic requires a long-term perspective, for wh
Analysis of signals defined on complex topologies modeled by graphs is a topic of increasing interest. Signal decomposition plays a crucial role in the representation and processing of such information, in particular, to process graph signals based on notions of scale (e.g., coarse to fine). The graph spectrum is more irregular than for conventional domains; i.e., it is influenced by graph topolog
Purpose: To evaluate the interday repeatability in the measurement of parameters used for the detection of progression of keratoconus by prediction limits (PL) for single measurements, and the repeatability coefficient (RC) for the mean of replicate measurements. Design: Prospective reliability analysis for cases and control eyes. Methods: Twenty-five eyes in 25 subjects with KC and 25 eyes in 25
In the last 15 years or so, soft selective sweep mechanisms have been catapulted from a curiosity of little evolutionary importance to a ubiquitous mechanism claimed to explain most adaptive evolution and, in some cases, most evolution. This transformation was aided by a series of articles by Daniel Schrider and Andrew Kern. Within this series, a paper entitled “Soft sweeps are the dominant mode o
Allergic rhinitis (AR) poses a global health problem and can be challenging to treat. Many of the current symptomatic treatments for AR have been available for decades, yet there has been little improvement in patient quality of life or symptom burden over the years. In this review, we ask why this might be and explore the pathophysiologica
BACKGROUND: Current guidelines recommend that comatose out-of-hospital cardiac arrest patients with ST-segment elevations (STEs) following return of spontaneous circulation (ROSC) should be referred for an acute coronary angiography. We sought to investigate the diagnostic value of the pre-hospital ROSC-ECG in predicting ST-elevation myocardial infarction (STEMI).METHOD: ROSC-ECGs of 145 comatose
The effect of lesions of two excitatory afferent pathways on the cellular damage in the hippocampus following complete cerebral ischaemia was investigated in the rat Lesions transecting the perforant path led to a significant decrease in cellular damage in the hippocampal CA1 region ipsilateral to the lesion as compared to the contatterai side and to control. Lesions of the fimbria-fornix, on the
This thesis investigates the generation and evaluation of tetrahedral meshes based on tomographic data of open-cell aluminum metal foam. The work focuses on creating volume meshes suitable for finite element analysis (FEA), starting from a 3D reconstruction of the metal foam microstructure derived from a stack of over 1000 CT-like image slices, tomographs. The work was based on, and extended a Py
Fermentation of Ulva spp., a protein-rich green macroalga, offers a sustainable approach for utilising an available resource and developing functional food ingredients. However, its high levels of inorganic matter, polyphenols, and complex polysaccharides such as ulvan pose challenges to microbial metabolism. This study investigated the effects of various pretreatment strategies, including hot wat
Syftet med denna studie var att kvalitativt utforska lärares syn på kunskapsbildning och kommunikation om klimatförändringar med elever i Vietnam, ett land med förhöjd klimatrisk. Med utgångspunkt i Hanoi genomfördes åtta (N = 8) semistrukturerade intervjuer med lärare på temat klimatundervisning. Materialet bearbetades sedan i en tematisk analys med abduktiv metod: delvis datadriven, delvis genomThis study qualitatively explored a sample of teachers' climate change conceptualizations and communication with school students in Vietnam, a country with high susceptibility to major climate change-related impacts. Fieldwork was conducted in Hanoi, where eight (N = 8) teachers were interviewed in a semi-structured format, focusing on the topic of climate change education. The material was ex
