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We have determined the solution structure of an albumin binding domain of protein G, a surface protein of group C and G streptococci. We find that it folds into a left handed three-helix bundle similar to the albumin binding domain of protein PAB from Peptostreptococcus magnus. The two domains share 59% sequence identity, are thermally very stable, and bind to the same site on human serum albumin.

Event-related potentials (ERPs) and behavioral measures were used to investigate recognition memory and source-monitoring judgements about previously perceived and imagined pictures. At study, word labels of common objects were presented. Half of these were followed by a corresponding picture and the other half by an empty frame, signalling to the Ss (aged 20-35 yrs) to mentally visualize an image

The paper considers a problem of routing, protection and load balancing in the IP/MPLS network. A network design problem combining all these aspects is presented. Proportionally fair distribution of residual bandwidths on links is used for load balancing, and protection is achieved with failure-dependent backup paths. The efficiency of the proposed approach is tested by combining optimization and

This paper presents the development of a system dynamic model to simulate and analyze desertification. The human-environment coupled model integrates socio-economic drivers with bio-physical drivers of biomass production, land degradation and desertification. It is based on the UN and GEF definitions of desertification. It illustrates the concept of desertification through differential equation an

We present exact algorithms with exponential running times for variants of n-element set cover problems, based on divide-and-conquer and on inclusion-exclusion characterisations. We show that the Exact Satisfiability problem of size 1 with m clauses can be solved in time 2(m)l(O(1)) and polynomial space. The same bounds hold for counting the number of solutions. As a special case, we can count the

As the chemical environment of semen diluents can have a profound effect on sperm quality, we examined the effect of temperature and pH on the motility and viability of sperm in the ostrich. Semen was collected from four males, each male being replicated three times. Ejaculates were diluted and incubated for 10 min at 20 degrees C and 40 degrees C in four different buffers, temperature adjusted at

Everett C. Hughes's classic concept of a "going concern" should stand for both entire institutions and for chains of activities within institutions. In this article the author explores this expanded version of Hughes's concept to show how staff and residents in a youth care setting interweave everyday concerns-meals, lessons, breaks, meetings, or other mundane but concerted projects-with interpers

Popular Abstract in Swedish Det talas mycket om rättvis fred i den allmänna debatten men det är ett ämne som är lite utforskat av akademiker. Det vetenskapliga pusslet som ligger till grund för denna avhandling är att undersöka vad en rättvis fred är, dels konceptuellt i fredsbyggande mer generellt, och empiriskt i förhållande till EU och den israelisk-palestinska konflikten. EU har använt termeJust peace has been much talked about in everyday life, but it is less well researched by academics. The puzzle underlying this dissertation is therefore to probe what constitutes a just peace, both conceptually within the field of peacebuilding and empirically in the context of the EU as a peacebuilder in the Israeli-Palestinian conflict. The EU has used the term just peace in many of its most

Combination therapies with inhaled corticosteroids (ICS) and either long-acting ß2 agonists (LABA) or leukotriene receptor antagonists (LTRA) are commonly used to help patients maintain control of their asthma. LABA and LTRA have different mechanisms of action and both provide complementary benefits when combined with ICS. This paper compares the two regimens based on recent clinical trial data, e

The move towards fire performance-based design in building and transport regulations has led to an increased use of fire models. This increased use of these models and the evolution of different regulations have put higher demands on the predictive capability of fire models. The purpose of this paper is to give an overview of different activities relating to the validation and verification of comp

Purpose - One current trend in burner technology is to obtain high efficiency while keeping low levels of NOx emissions. A swirling flow in combustion ensures a fixed position of a compact flame. Therefore, it is necessary to design efficient swirlers. Flow patterns are simulated for the different swirl devices proposed in this work. Two axial-swirlers are studied: one based on curve-vanes consist

Context. Elements heavier than Li are produced in the interiors of stars. However, for many elements the exact production sites and the timescales on which they are dispersed into the interstellar medium are unknown. Having a clear picture on the origins of the elements is important for our ability to trace and understand the formation and chemical evolution of the Milky Way and its stellar popula

Gaucher disease (GD) patients cannot metabolize glycosphingolipids properly due to deficiency of the enzyme glucosylceramidase (GCase). The lack of animal model for GD has hindered comprehensive investigation of disease mechanisms and also the development of curative treatment strategies such as hematopoietic stem cell (HSC) targeted gene therapy. Previous GCase deficient mice have either been let