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The development of a predictive control algorithm for glycaemia regulation in diabetic subjects requires patient-specific models of the glucose metabolism which are physiologically relevant, parsimonious, yet able to accurately forecast blood glucose. Given the measured data: total plasma insulin [mIU/L]; plasma glucose [mg/dL]; plasma glucose rate of appearance after intestinal absorption [mg/kg
One of the latest additions in defining the test process is the upcoming ISO/IEC 29119 standard, which aims to define a universally applicable generic test process model. However, currently the standard does not offer any support for the adoption process of the model. In this paper, we present our framework, which aims to combine a maturity level-based approach with the standard process. Our objec
The software engineering community has proposed numerous approaches for making software self-adaptive. These approaches take inspiration from machine learning and control theory, constructing software that monitors and modifies its own behavior to meet goals. Control theory, in particular, has received considerable attention as it represents a general methodology for creating adaptive systems. Con
Various proxy records have been used for the understanding of environmental and climate variations during the Holocene. Here, for the first time, we use meteoric 10Be isotope measurements performed on sediments from a drill core collected at the Kunlun Pass (KP) on the northeastern Qinghai-Tibet Plateau (NETP) to investigate hydroclimate changes during the Holocene. The 10Be flux suggests relative
Background: Avoidable mortality is considered as a potential indicator of the influences of public health policies and healthcare quality on population health. This study aimed to examine the trend in avoidable mortality and its influence on rising life expectancy (LE) and declining gender gap in LE (GGLE) in Sweden. Methods: We extracted data on causes of death by age, sex, and year from nationa
Background Clinical outcomes after major surgery are poorly described at the national level. Evidence of heterogeneity between hospitals and health-care systems suggests potential to improve care for patients but this potential remains unconfi rmed. The European Surgical Outcomes Study was an international study designed to assess outcomes after non-cardiac surgery in Europe.Methods We did this 7
Neurofilament light (NfL) is a marker of neuroaxonal injury, a prominent feature of Alzheimer's disease. It remains uncertain, however, how it relates to amyloid and tau pathology or neurodegeneration across the Alzheimer's disease continuum. The aim of this study was to investigate how plasma NfL relates to amyloid and tau PET and MRI measures of brain atrophy in participants with and without cog
Aim: The first Swedish National Guidelines for Ovarian Cancer (NGOC) were published in 2012. We aimed to evaluate surgical outcomes and survival in patients with stage IIIC-IV disease, before and after the NGOC implementation. Method: Women with primary epithelial ovarian cancer, FIGO stage IIIC–IV, registered in the Swedish Quality Registry for Gynecologic Cancer 2008–2011 and 2013–2016 were incl
Empirical software engineering research relies on good communication with industrial partners. Conducting joint research both requires and contributes to bridging the communication gap between industry and academia (IA) in software engineering. This study aims to explore communication between the two parties in such a setting. To better understand what facilitates good IA communication and what pr
Understanding the transport and deposition of the cosmogenic isotope 10Be is vital for the application of the isotope data to infer past changes of solar activity, to reconstruct past Earth’s magnetic field intensity and climate change. Here, we use data of the cosmogenic isotope 10Be from the Greenland ice cores, namely the NEEM and GRIP ice cores, to identify factors controlling its distribution
The threat that solar storms pose to our ever-modernizing society has gathered significant interest in the recent past. This is partly due to the discoveries of large peaks in the content of cosmogenic radionuclides such as radiocarbon (14C) in tree rings and beryllium-10 (10Be) and chlorine-36 (36Cl) in ice cores that were linked to extreme solar storms dated to the past millennia. To better asse
Sea spray aerosol (SSA) contributes significantly to natural aerosol particle concentrations globally, in marine areas even dominantly. The potential changes of the omnipresent inorganic fraction of SSA due to atmospheric ageing is largely unexplored. In the atmosphere, SSA may exist as aqueous phase solution droplets or as dried solid or amorphous particles. We demonstrate that ageing of liquid N
Background: The complexity of pancreaticoduodenectomy and fear of morbidity, particularly postoperative pancreatic fistula, can be a barrier to surgical trainees gaining operative experience. This meta-analysis sought to compare the postoperative pancreatic fistula rate after pancreatoenteric anastomosis by trainees or established surgeons. Methods: A systematic review of the literature was perfor
Explosive volcanic eruptions can reach the stratosphere and cause elevated concentrations of sulphate particles for months to years. When these particles descend into the troposphere, they can impact cirrus clouds though to what degree is unknown. In this study, we combine three satellite data sets to investigate the impact of downwelling sulphate aerosol on midlatitude cirrus clouds during spring
Atmospheric new-particle formation (NPF) affects climate by contributing to a large fraction of the cloud condensation nuclei (CCN). Highly oxygenated organic molecules (HOMs) drive the early particle growth and therefore substantially influence the survival of newly formed particles to CCN. Nitrogen oxide (NOx) is known to suppress the NPF driven by HOMs, but the underlying mechanism remains larg
Smoke from western North American wildfires reached the stratosphere in large amounts in August 2017. Limb-oriented satellite-based sensors are commonly used for studies of wildfire aerosol injected into the stratosphere (OMPS-LP (Ozone Mapping and Profiler Suite Limb Profiler) and SAGE III/ISS (Stratospheric Aerosol and Gas Experiment III on the International Space Station)). We find that these m
The Sun sporadically produces eruptive events leading to intense fluxes of solar energetic particles (SEPs) that dramatically disrupt the near-Earth radiation environment. Such events have been directly studied for the last decades but little is known about the occurrence and magnitude of rare, extreme SEP events. Presently, a few events that produced measurable signals in cosmogenic radionuclides
