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Cell replacement therapies for Parkinson's disease (PD) based on transplantation of pluripotent stem cell-derived dopaminergic neurons are now entering clinical trials. Here, we present quality, safety, and efficacy data supporting the first-in-human STEM-PD phase I/IIa clinical trial along with the trial design. The STEM-PD product was manufactured under GMP and quality tested in vitro and in viv
Background: In Sweden, vaccine uptake is exceptionally high due to an efficient child immunization program. More than 97% of Swedish children were vaccinated at child health care centers (CHCs) according to the schedule at 2 years of age in 2021. From the age of 6 years, vaccinations are given within the school health care. Maintaining high vaccination coverage over time is one of the central moti
The manifestation of extreme solar proton events (SPEs) in Beryllium-10 (10Be) ice core data contains valuable information about the strength and incidence of SPEs or local characteristics of the atmosphere. To extract this information, the signals of enhanced production of cosmogenic 10Be due to the SPEs have to be detected, hence distinguished from the variability of the background production by
A search for high-mass resonances decaying into a Formula Presented-lepton and a neutrino using proton-proton collisions at a center-of-mass energy of Formula Presented is presented. The full run 2 data sample corresponding to an integrated luminosity of Formula Presented recorded by the ATLAS experiment in the years 2015-2018 is analyzed. The Formula Presented-lepton is reconstructed in its hadro
Background and Purpose: Possibilities to age in place are increasingly important with the demographic shift toward aging populations. With the Person-Place Fit Measure for Older Adults (PPFM-OA), older adults self-assess how their home and community environments suit their needs. The aim of the study was to evaluate the psychometric properties of the Swedish version of PPFM-OA. Methods: Four hund
No abstract. Prepared for Linnédelegationen, Stockholm, Sweden.
Massive MIMO has been shown, both in theory and through experiments, to offer very promising properties. These include the possibility to decrease output power by at least an order of magnitude while still achieving large gains in spectral efficiency, as compared to today’s access schemes. To efficiently design communication algorithms and evaluate massive MIMO schemes, channel models that capture
The gene for beta-microseminoprotein MSMB has been studied by DNA hybridization and molecular cloning techniques. Comparative analysis of restriction endonuclease digests of the cloned gene and of leukocyte DNA strongly suggested that the gene is present in a single copy in the haploid human genome. By Southern blot analysis of DNA from somatic cell hybrids, the gene was assigned to chromosome 10.
A stochastic model based on a probability density function (PDF) was developed for the investigation of different conditions that determine knock in spark ignition (SI) engine, with focus on the turbulent mixing. The model used is based on a two-zone approach, where the burned and unburned gases are described as stochastic reactors. By using a stochastic ensemble to represent the PDF of the scalar
Polarized inelastic neutron scattering under a magnetic field is used to get a microscopic insight into the spin resonance of the heavy fermion superconductor CeCoIn5. The resonance line shape is found to depend on the neutron polarization: Some of the spectral weight is common to the two polarization channels while the remaining part is distributed equally between them. This is evidence for the s
While the terms soft power, public diplomacy (PD) and nation brands have cemented their place in academic discourse during the early 21st century, the evaluation of these activities has not been given anywhere near the same level of attention. When describing how campaigns are evaluated, scholars tend to make assumptions based on the goals or outputs of an initiative rather than on the basis of re
Rocky planets may acquire a primordial atmosphere by the outgassing of volatiles from their magma ocean. The distribution of O between H2O, CO, and CO2 in chemical equilibrium subsequently changes significantly with decreasing temperature. We consider here two chemical models: one where CH4 and NH3 are assumed to be irrevocably destroyed by photolysis and second where these molecules persist. In t
This chapter is concerned with Turkish heritage speakers (HSs) in Germany, here exemplified by 21 early bilinguals during adulthood who live in Hamburg, North Germany. We introduce the population, report their self-perceived proficiency and propose the Turkish Use Score (TUS) that is based on quantitative aspects of language use (e.g., the number of people Turkish is spoken with) and qualitative o
III-Nitride based LEDs based on InGaN active layers on GaN work very well for the blue and green emitting LEDs. However, the large lattice mis-match between redemitting active layers, with at least 35% indium in the active layers, and the GaN substrate still limits the efficiencies obtained to very low values. Unfortunately, the approach to use GaAs based (GaAs/AlInGaP) devices for the red fails f
