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Ribonucleotide reductases (RNRs) are important enzymes that convert the building blocks of RNA (NTPs) into building blocks of DNA (dNTPs). dNTPs are used for synthesis of DNA as well as repair of mutated and damaged DNA. These cellular processes are critical to an organism. That is why these processes are found in various organisms. Since these processes are so essential, their allosteric regulati
Att behandla tumörsjukdomar genom injektion av radioaktiva läkemedel är en behandlingsteknik kallad radionuklidterapi. Det radioaktiva läkemedlet består av en radioaktiv isotop, fäst på en målsökande bärarmolekyl, specifik för den vävnad vari man önskar att läkemedlet skall ansamlas. Då den radioaktiva isotopen sönderfaller sänds joniserande strålning ut; strålning med förmågan att jonisera molekyIntroduction: There is a need of reassessment of radiation absorbed dose specification in nuclear medicine, taking the non-uniformities in the distribution of radioactivity into account. This is especially important in radionuclide therapies where very high activities are administered and the radionuclides emit alpha particles, beta particles or low-energy electron and will require absorbed dose c
Introduction: Idiopathic normal pressure hydrocephalus (iNPH) is a treatable but largely underdiagnosed neurological condition affecting the elderly population. It is characterised by gait and cognitive impairment, as well as urinary incontinence. For the most part, it is diagnosed via imaging and clinical assessments. Abnormalities in cerebrospinal (CSF) flow in the cerebral aqueduct have been li
The aim of this essay is to examine the phrasing of gender equality in the 2030 Agenda for Sustainable Development focusing on Goal 5: Gender Equality. The focus of the study also extends to analyze the potential consequences of the goal’s phrasing and understand why the empowerment of women and girls are seen as essential for the progression on all levels of sustainability. Through qualitative in
The focus of this master’s thesis has been getting a six-legged robot to autonomously navigate around a room with obstacles. To make this possible a time-of-flight camera has been implemented in order to map the environment. Two force sensing resistors were also mounted on the front legs to sense if the legs are in contact with the ground. The information from the sensors together with a path plan
Mobile robotics is an expanding field worldwide leading to the need for advanced path-planning algorithms that can traverse various environments. Current state-ofthe- art path-planning algorithms used at the Swedish Defence Research Agency, FOI, tend to be inflexible and parameter dependent. The parameters might need to be tuned for each new environment, which is a very labor-intensive process. T
The purpose of this paper is to investigate consumers’ decision making for purchases in physical stores and the effect of a cooling-off period in this process. The theories and models that have been used are the expected utility theory, the regret theory, the prospect theory and the projection bias. By means of these theories the paper analyses if a cooling-off period has an effect ex ante or ex p
The purpose of this study was to highlight professionals’ views and aims of using touch screen technology, such as tablets, whilst working with people with dementia. The usage of touch screen technology whilst supporting people with dementia was found to be getting more and more common in today’s society. The study has underlined how the professionals described the tablet, what aims there were by
Background: Cataracts are the leading cause of reversible blindness globally, disproportionately affecting populations in low- and middle-income countries. In Ethiopia, cataracts remain a significant public health concern. Despite the effectiveness of cataract surgery in restoring vision, information on recovery time and its predictors remain limited. The aim of this study was to assess time to re
Importance Women with adverse pregnancy outcomes have higher subsequent cardiovascular risks, but their long-term risk of atrial fibrillation (AF) and potential causality are unclear. A better understanding of such risks is needed to identify women with high risk early in life and guide interventions to prevent AF and its complications. Objective To determine long-term risks of AF associated with
Importance: Traditional adoption studies examine disorder-to-disorder parent-offspring transmission. The role of parental genetic risk in offspring disorder transmission can capture indirect genetic effects from parental genotype to parental phenotype to offspring risk. Objective: To assess the relative importance of genetic and rearing effects from paternal family genetic risk scores (FGRSs) in 3
Background Pulmonary nodules (PNs) are clinically challenging because differentiation between benign and malignant PNs is not possible at CT detection; recurring CT examinations and invasive procedures are often required in PN follow-up. Purpose To investigate PN prevalence in a middle-aged population and the risk factors associated with these nodules. Materials and Methods In this secondary analy
This article explores the processes that led to the inclusion of psychedelics under the 1971 Convention on Psychotropic Substances, a cornerstone of international drug control. Drawing on archival records, we analyze the narratives and dynamics that shaped this decision. Despite limited scientific evidence of public health dangers, concerns about psychedelics were amplified by sensationalized medi
Blood biomarkers have the potential to revolutionize Alzheimer's disease diagnosis, offering advantages over CSF and PET due to their accessibility, scalability and cost-effectiveness. This study evaluated the effectiveness of individual plasma biomarkers, such as phosphorylated Tau (pTau) 217, as well as biomarker combinations, with a focus on the pTau 217/β-Amyloid (Aβ) 1–42 ratio to predict amy
There is an urgent need for accurate and validated methods to measure plasma phosphorylated tau (p-Tau) biomarkers in Alzheimer’s disease (AD). In this study, we compared the performance of new commercially available plasma p-Tau217 assay developed by ALZpath to other established p-Tau assays in an autopsy-confirmed sample. We included 72 participants from the Arizona Study of Aging and Neurodegen
Background: The Influenza – Monitoring Vaccine Effectiveness in Europe (I-MOVE/I-MOVE+) and Vaccine Effectiveness, Burden and Impact Studies (VEBIS) hospital networks have conducted seasonal multicentre, test-negative, case–control studies in Europe to measure influenza vaccine effectiveness (IVE) since 2015/16. We measured the effect of chronic conditions on VE of influenza A subtypes among older
Background: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not i
Before performing 177Lu-DOTATATE therapy for neuroendocrine tumors, somatostatin receptor (SSTR) PET imaging is currently used to confirm sufficient tumor SSTR expression, but it also has potential to be used to personalize treatment by predicting absorbed doses to critical organs. This study aims to validate the predictive capability of SSTR PET in anticipating renal absorbed dose in the first cy
Evidence from neuropathological cohorts indicates that a CSF α-synuclein (α-syn) seed amplification assay (SAA) might provide quantitative kinetic parameters correlating with α-syn pathology burden in patients with Lewy body disease (LBD). Studies are needed to assess their longitudinal trend during the presymptomatic and clinical disease phases and their correlation with measures of disease progr
