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PURPOSE: Four-pool Voigt (FPV) machine learning (ML)-based fitting for Z-spectra was developed to reduce fitting times for clinical feasibility in terms of on-scanner analysis and to promote larger cohort studies. The approach was compared to four-pool Lorentzian (FPL)-ML-based modeling to empirically verify the advantage of Voigt models for Z-spectra.METHODS: Voigt and Lorentzian models were fitt
Overview: Prostate cancer (PC)is the most common cancer in Sweden, and the leading cause of cancer death. Positronemission tomography with x-ray computed tomography (PET/CT) is an important imagingmethod for many cancers. A group of PET radiopharmaceuticals known as PSMA(prostate specific membrane antigen) ligands has been introduced for imaging ofPC. This thesis investigates aspects of the ligand
Multiple sclerosis leads to diffuse damage of the central nervous system, affecting also the normal-appearing white matter. Demyelination and axonal degeneration reduce regional fractional anisotropy in normal-appearing white matter, which can be routinely mapped with diffusion tensor imaging. However, the standard fractional anisotropy metric is also sensitive to physiological variations in orien
Background: Neuropsychiatric symptoms (NPS) are common in individuals with Alzheimer’s disease (AD) dementia, but substantial heterogeneity exists in the manifestation of NPS. Sex differences may explain this clinical variability. We aimed to investigate the sex differences in the prevalence and severity of NPS in AD dementia. Methods: Literature searches were conducted in Embase, MEDLINE/PubMed,
The urbanization of landscapes and the increase in impervious land cover materials is known to cause significant changes in the landscape's thermal properties, typically leading to urban heat island (UHI). Although previous studies have investigated the impacts of land cover land use (LULC) and other factors on the urban land surface temperature (LST), the results of such studies are mixed. For in
BACKGROUND: Patients with diabetes have increased rates of major adverse cardiac events (MACEs). We hypothesized that this is explained by diabetes-associated differences in coronary plaque morphology and lipid content. METHODS: In PROSPECT II (Providing Regional Observations to Study Predictors of Events in the Coronary Tree), 898 patients with acute myocardial infarction with or without ST-segme
OBJECTIVE: The objective of the present study is to investigate the feasibility of using heart rate characteristics to estimate atrial fibrillatory rate (AFR) in a cohort of atrial fibrillation (AF) patients continuously monitored with an implantable cardiac monitor (ICM). We will use a mixed model approach to investigate population effect and patient specific effects of heart rate characteristics
The Swedish carbon tax of 1991, one of the first of its kind, has positioned Sweden as a forerunner in climate governance. It is often depicted an international success and today constitutes the backbone of Swedish climate policy. At first, however, the tax received widespread criticism and had limited political support. The policy design process was short, with limited time for deliberation. Whil
Digital healthcare has proven to be increasingly important as the pressure on primary healthcare is enhanced, with a growing elderly population that lives longer. The importance of an effective digital healthcare with high quality is consequently increasing. By creating a reliable model, using machine learning algorithms, that can predict the next action for a caregiver in digital healthcare, not
Ever since the dawn of internet, a new wave of fast-growing software companies has emerged. The M&A scholars have struggled to find appropriate valuation mechanisms for unprofitable companies with ultra-high revenue growth. To overcome the uncertain future, a contractual provision called earnout is often used. An earnout is a contractual provision in a M&A-deal that states the seller of th
The culture proposal "Time for culture" emphasizes that the financial responsibility should not only be dependent on public funding, but private funders and non profit agencies should also take increased financial responsibility. The increasing demand for financial independency, has created a new position for cultural institutions. This has led to this study that wants to find out how th
Sammanfattning Skatteverket kan företa revisioner hos i huvudsak bokföringsskyldiga skattskyldiga, i regel näringsidkare, för att granska riktigheten av de uppgifter som lämnats till Skatteverket i deklarationer och kontrolluppgifter. Vid dessa revisioner granskas den skattskyldiges bokföring och andra underlag för att stämmas av mot de uppgifter som lämnats till Skatteverket. Skatteverket kan äSummary The Swedish Tax Agency is authorized to carry out audits, mainly with accountable taxable’s, normally corporations, in order to scrutinize the accuracy of the information that has been submitted to the Swedish Tax Agency through income tax returns and statements of earnings. In such audits the taxable’s accounting and other materials are compared against the information that has been submi
In the past people sought for information via libraries, travel magazines or were inspired by marketing the travel agency made in order to attract consumers. Before the Internet era one way communication was the right way to follow. Since Internet was developed two ways communication has evolved and people can talk to each other worldwide. The development of the two ways communication has created
With an increasingly population and urbanization, the solid waste management have become a major challenge for local authorities in developing countries all over the world. The local authorities must improve their waste management in order to minimize the negative effects of solid waste and to avoid future land use conflicts. At the same time the economical resources are limited and solid waste ma
Dealing with water diffuse pollution is a major problem for watershed managers. This problem raises many complicated questions, which are important to answer in order to reach water environment protection goals. This study suggested some possible answers for the country of Lithuania. Among them were the identification of critical source areas, the identification of sensitive areas and the applicat
Enzyme engineering for a better future It is essential for many organisms on this planet to be able to digest plants. One of those organisms is the blue mussel, which uses certain enzymes in its stomach to break down sugar fibers in the algae that it eats. But how does this really work, and can we use it for anything? Plant cells have very strong walls, protecting them from environmental stress.
Electricity finds itself different from other fresh-ware commodities, it cannot easily be stored. This characteristic trait of electricity results in traditional pricing methods not working for electricity pricing. Thus different pricing schemes are needed, such as Price Forward Curves (PFC) or pricing against a price level. The price forward curves are constructed through a mix of historical mark
Städer har historiskt sett utgjort den centrala delen för politiska beslut, ekonomisk tillväxt och bidragit till revolutionerande forskning. På senare år har städerna fått en mer betydande roll i samhället, vilket har lett till att behovet att planera städer som främjar hållbar utveckling har ökat. Detta medför stora utmaningar för den fysiska planeringen av städer och inom Sveriges gränser ställeDuring the recent decades the conditions for how our cities are developed has gained a more significant role in society, resulting in an increasing need to plan cities that promote sustainable development. This entails challenges in changing the direction of today’s spatial planning into a more sustainable one, a challenge that requires that all stakeholders work together to create attractive citi
The purpose of this study was to look at two autobiographies through qualitative methods. The main purpose has been to highlight how individuals describe themselves, the consequences of social aspects (family and friends) in depression they have experienced and their turning points: the way out of the depression. To study this, I have used the following questions as starting points: How do the dep
