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Obesity and diabetes are known to impact brain function and alter metabolism. Studies in rodents show that consumption of high fat and high sugar diets lead to brain dysfunction affecting memory and cognition, and increases risk of cerebro-vascular and neurodegenerative disorders. Striatum, which is involved in reward-based behaviour and motor control, undergoes changes on exposure to such diets l
After four years of independence, Kosovo continues to face severe social, political and economic challenges that pose several threats to the development and legitimacy of the new state. A field study was carried out in Kosovo in January–March 2012 with the purpose of creating a deeper understanding of the state-building process and test Alan Whaites’s theory of responsive and unresponsive state-
Introduction: A new-born with congenital heart disease requires care that involves numerous specialists. Such care can be provided at tertiary referral hospitals and transportation is often needed. A crucial factor is the handover process, when the child is born at a distance, with transfer of both professional responsibility and continued care from one healthcare professional to another. Aim: The
A measurement of the Standard Model Higgs boson produced in association with a W or Z boson and decaying into a pair of τ-leptons is presented. This search is based on proton-proton collision data collected at s=13 TeV by the ATLAS experiment at the LHC corresponding to an integrated luminosity of 140 fb−1. For the Higgs boson candidate, only final states with at least one τ-lepton decaying hadron
The aim of this paper is to outline a process-based approach to the historical trajectory of commercialising cities that can account for continuity and change in a city’s image. Previous research involving historical approaches to the commercialisation of places are typically underpinned by a view of history as linear and chronological. By contrast, the present study adopts a performative view of
This thesis is based on the work that was done during 1992--1996 at the DELPHI detector at LEP. Its main parts are outlined below. The brief Introduction gives an overview of the science of Particle Physics, its development and contemporary status. The first chapter represents an introduction to the DELPHI detector at LEP, describing the main features of the LEP machine and the DELPHI detector a
Our aim was to describe patient flows in mandibular third molar surgery at ora I and maxillofacial specialist units. Our hypothesis was that there are variations in how care is delivered and that the variations could be explained by inter-individual variations in surgeons' practice,the quality of the radiographs appended to the referral, and the staffing of the specialist units. A flow chart was c
Twenty-four children (aged 5 months to 18 years) who were admitted to a university hospital were observed for a total of 135 hours with the aim of describing their degree of participation in decisions concerning their own care. Grading of their participation was made by using a 5-point scale. An assessment was also made of what was considered as optimal participation in each situation. The results
Background: Metabolic reprogramming, particularly glycolysis, is essential in processes like cancer and immune response. While FGF21's role in hepatocyte glucose metabolism has been linked to glucose transporters and its impact on aerobic glycolysis and cellular growth in HCC remain unclear. In this study, we investigated FGF21-mediated modulation of glucose metabolism in HCC through mTOR and HIF1
During the last decades, increased concentrations of natural organic matter (NOM) and colour of surface waters have been reported from northern Europe and North America. Since surface waters are widely used for drinking water production this development has been problematic for drinking water producers. Even though NOM in itself is not harmful, it can cause production of undesirable disinfection b
This study aims to contribute knowledge to the needs of managers in support of the return-to-work process of a burnt-out employee. This study explores managers’ perspectives on the organisational factors that they experience, how these factors affect them in the return to work process for a burnt out employee, and how these factors affect their feeling of being supported by their organisations and
This study focus on the gelation process of 1-methylidene ethane-1,2-dicarboxylic acid (MIA) polyesters and what causes the gelation. The influence of oxygen during the syntheses, how the molecular weight is affected and how the polyester changes chemically was studied. Analytical methods used were SEC, titration and NMR. The replicability of the experiments was investigated and confirmed. Testing
Mitochondrial quality control prevents accumulation of intramitochondrial-derived reactive oxygen species (mtROS), thereby protecting cells against DNA damage, genome instability, and programmed cell death. However, underlying mechanisms are incompletely understood, particularly in fungal species. Here, we show that Cryptococcus neoformans heat shock factor 3 (CnHsf3) exhibits an atypical function
