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The tumor suppressor gene p53 can mediate both apoptosis and cell cycle arrest. In addition, p53 also influences differentiation. To further characterize the differentiation inducing properties of p53, we overexpressed a temperature-inducible p53 mutant (ptsp53Val135) in the erythroleukemia cell line K562. The results show that wild-type p53 and hemin synergistically induce erythroid differentiati
Background: Women are at increased risk of developing anxiety or depression disorders after Cesarean section (CS). This study aims to evaluate whether an appointment with a senior obstetrician combined with an ultrasound examination reduces levels of anxiety in women after CS. Methods: A prospective observational study was conducted in Sweden. Women underwent an appointment with an obstetrician 6–
1. Dementia is a clinical syndrome with several causes whichcreates impairments in mental ability, personality, affect andsocialisation.2. Information from family members can be very useful in theearly identification of cognitive impairment.3. Patients presenting with cognitive impairment should be evaluatedfor potentially reversible causes, with a range of laboratorytests and investigations.4. Sh
Epidemiologists have for many decades reported on the patterns and distributions of diabetes within and between populations and have helped to elucidate the aetiology of the disease. This has helped raise awareness of the tremendous burden the disease places on individuals and societies; it has also identified key risk factors that have become the focus of diabetes prevention trials and helped sha
Wide-angle neutron scattering experiments combined with empirical potential structural refinement modeling have been used to study the detailed structure of decyltrimethylammonium bromide micelles in the presence of acid solutions of HCl or HBr. These experiments demonstrate considerable variation in micelle structure and water structuring between micelles in the two acid solutions and in comparis
Bertrand Russell’s speech “Why I Am Not a Christian” (1927) triggered many theologians to defend Christian beliefs. Aside from his rational criticism of the so-called “proofs” of God’s existence, it is his humorous irony as a rhetorical weapon that made many abandon their faith in Christianity and become atheists or at least agnostics. In this article I examine two British theologians’ unsuccessfu
In recent years Genuine Savings (GS) has emerged as an indicator of weak sustainability and predictor of socio-economic well-being. This paper presents the first long-term GS estimates for Norway, covering the period from 1865 until 2018. The preliminary results indicate unsustainable development throughout most of the period leading up to the Second World War and positive GS since 1946, with a si
This book investigates the activities undertaken by the variety of actors that contribute to accomplishing cultural policy in Europe. These range from policy formulation and administration at the national and local levels, to artistic and cultural production activities to institutional governance.
This chapter focuses on the diplomatic, security, and defence dimensions of EU foreign policy. Developments in the last decade, not least Russia's annexation of Crimea, China's increasing global political - and not only economic - prevalence, and America's reoriented foreign policy all speak to this dynamic - and also render the EU a more challenging position in international relations. Recognitio
This chapter reviews the most important beginning with the long tradition of prescriptive tracts, offering observations and advice concerning the conduct of diplomacy. Authors from du Rosier to Nicolson were practitioners, who not only aimed at describing and explaining diplomacy but also had a clear prescriptive bent, offering recommendations as to the best conduct of diplomacy. War and military
