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Immigrant populations from the Middle East develop diabetes earlier than indigenous European populations; however, the underlying etiology is poorly understood. This study looked at the risk factors associated with early diabetes onset and, in non-diabetics, glycaemic control in immigrants from Iraq compared with native Swedes.
Objective. To investigate the in vitro effects of 6,7-dihydroxycoumarin (esculetin) on the production of matrix metalloproteinases (MMP) in rabbit articular cartilage, and the in vivo effects of orally administered CPA-926, a prodrug of esculetin, on cartilage destruction in rabbit experimental osteoarthritis (OA). Methods. In vitro studies were performed using rabbit articular cartilage explants.
Diabetes mellitus is a group of diseases characterized by chronic hyperglycemia. Women who develops hyperglycemia for the first time during pregnancy receive the diagnosis gestational diabetes mellitus (GDM). Presently, there is no consensus about the diagnostic criteria for GDM. A majority of these women subsequently develop postpartum overt diabetes making it important to identify these patients
Abstract This study relates soil organic matter (SOM) characteristics to initial soil incubation carbon release from upper permafrost samples in Yedoma region soils of northeastern Siberia, Russia. Carbon (C) and nitrogen (N) content, carbon to nitrogen ratios (C:N), δ13C and δ15N values show clear trends that correspond with SOM age and degree of decomposition. Incubation results indicate that ol
Background: People with psychosis have a reduced life expectancy of 10-20years, largely due to cardiovascular disease. This trial aimed to determine the effectiveness of a modular health promotion intervention (IMPaCT Therapy) in improving health and reducing cardiovascular risk in psychosis. Methods: A multicentre, two arm, parallel cluster RCT was conducted across five UK mental health NHS trust
Background: No previous studies have evaluated the performance of the Synergy stent in a large real-life population. Objectives: To describe the initial real-life experience with a novel everolimus eluting platinum chromium stent with abluminal biodegradable polymer (SYNERGY) in unselected patients from a nationwide registry. Methods: All implanted Synergy stents were compared with other new gener
Introduction: Drug-eluting stents (DES) reduce the risk of restenosis after percutaneous coronary intervention. The aim of the study was to evaluate, by intravascular ultrasound (IVUS), the minimum lumen area site in the stented segment and the distribution of intimal hyperplasia in patients presenting with a DES or bare-metal stent (BMS) in-stent restenosis. Methods: The “Nordic Intravascular Ult
Purpose: We present a case report that describes neoadjuvant denosumab therapy initiated in a child with a solitary giant cell-rich juvenile xanthogranuloma tumor involving the spine, and review the current literature.Methods: A giant cell-rich histiocytic lesion involving the 11th thoracic vertebral body was identified in a healthy 5-year-old girl with persistent back and pelvic pain for several
Moisture and ionic transport under non-saturated condition is an important, but poorly understood transport phenomena particularly for mature systems containing supplementary cementitious materials. This paper investigates the moisture and chloride profiles of 3-year old mortars containing Portland cement (OPC), slag and silica fume (SF) after long-term (30–48 months) wick action exposure in 1.09
A design of experiments analysis was performed to investigate the effects of pilot quantity, combustion phasing and exhaust gas recirculation on performance and emissions in a gasoline partially premixed combustion to find out the optimal combination of the all varied parameters. The experimental activities were performed on a light-duty Volvo Euro 6 diesel engine. The test was performed under ste
Objective: To determine factors associated with orthopaedic surgeons’ decision to recommend total joint replacement (TJR) in people with knee and hip osteoarthritis (OA). Design: Cross-sectional study in eleven countries. For consecutive outpatients with definite hip or knee OA consulting an orthopaedic surgeon, the surgeon's indication of TJR was collected, as well as patients’ characteristics in
Objective Polymorphisms in the CYP2R1 gene encoding Vitamin D 25-hydroxylase have been reported to correlate with circulating levels of 25-OH vitamin D3 (25(OH)D). It is unknown whether these variations also affect overall bone metabolism. In order to elucidate the overall associations of polymorphisms in the CYP2R1, we studied haplotype tagging single nucleotide polymorphisms (SNPs) in the gene a
This article looks at chronic crisis on an empirical example of radiation embodiment by survivors of a nuclear disaster. Developing further the work of Henrik Vigh, this article argues that chronic crisis is conflictual in nature, where some individuals fully embrace it, while others reject it. A total of 16 in-depth interviews were conducted with survivors of the Chernobyl nuclear disaster from B
Background: Fetal growth restriction (FGR) is a serious obstetric condition for which there is currently no treatment. The EVERREST Prospective Study has been designed to characterise the natural history of pregnancies affected by severe early onset FGR and establish a well phenotyped bio-bank. The findings will provide up-to-date information for clinicians and patients and inform the design and c
A three-dimensional (3D) direct numerical simulation (DNS) of an experimental turbulent premixed jet flame at high Karlovitz number was studied. The DNS resolution adequately resolves both the flame and turbulence structures. A reduced chemical mechanism for premixed CH4/air flames with NOx based on GRI-Mech3.0 was used, including 268 elementary reactions, and 28 transported species. Consistent po
