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Digital cognitive assessments have rapidly expanded in Alzheimer's disease (AD) research, offering a sensitive, scalable, and cost-effective alternative to traditional neuropsychological tests. This systematic review examines the validation and utility of digital cognitive assessments in cognitively normal (CN) individuals and explores their potential classification within the US Food and Drug Adm

Age estimation based on the dentition of animal remains is one of the most important methods used for analysis of the demography of past as well as contemporary animal populations by zooarchaeologists and wild game biologists (Wagenknecht 1967; Silver 1969; Morris 1972; Wilson et al. 1982). By constructing age profiles from faunal remains it is possible to study hunting of wild boar and pig husban

In the future, buildings need to be energy resilient to tackle the energy crisis. This article introduces a concept for classifying the energy resilience of buildings in extreme cold and warm weather in Finland during blackouts. It presents a techno-economic comparison between an old and a new single-family building integrated with photovoltaic (PV) systems and batteries, analyzing their resilienc

IntroductionMidwifery knowledge, education and training in practice are challenged in contemporary maternity care by the growing trend towards interventions during childbirth, a dominant risk perspective and medicalised care. There is an ongoing debate about the definition of normal birth, however, midwives continue to advocate for normal birth.ObjectiveTo explore midwives’ views and definitions o

We determine the composition dependence of the below-bandgap anisotropic refractive indices and dielectric functions of β-(AlxGa1−x )2O3 for x up to 25% Al. We use Mueller matrix generalized spectroscopic ellipsometry and investigate a set of high quality single crystalline bulk (x = 0 %, 5 %, 10 %, 15 %, 20 %, 25 %) and thin film (4.6%, 9.7%, 12%, 15%, 16.3%, 21%) samples grown by the Czochralski

BACKGROUND: In Sweden, approximately half of all individuals who die receive municipal care prior to death. Access to high-quality palliative care remains unequal, with known disparities between both care settings and diagnostic groups. Individuals receiving municipal home care are at higher risk of acute hospital admissions and in hospital death than those in long-term care facilities. However, t

Hot-wall metalorganic vapor phase epitaxy enables a superior quality of group-III nitride epitaxial layers and high electron mobility transistor structures, but has not yet been explored for N-polar growth. In this work, we aim at achieving N-polar AlN nucleation layers (NLs) with optimized properties for subsequent growth of GaN device heterostructures. The effects of substrate orientation on the

Background Long-term pathological breathlessness is a life-limiting symptom that risks taking control of the individual’s life. We aimed to evaluate how locus of control (LOC), an individual’s perceived control of present and past life events, relates to breathlessness in a middle-aged general population. Methods A population-based, cross-sectional analysis of people aged 50–64 years was conducted

Despite decades of experience in urban planning, Iran lacks a robust urban policy framework to guide its rapid urbanization toward sustainable and resilient development. Moreover, its existing sectoral policies have failed to operate within an integrated framework. The formulation of a National Urban Policy (NUP), as proposed by UN-Habitat, offers a unified structure to facilitate the preparation,

This study aimed to test and validate a dual-time-window (DTW) protocol for 6-(fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]MK6240) dynamic PET imaging in experimental datasets acquired in human subjects. Methods: DTW protocols were tested and validated in datasets previously collected in 25 participants: 13 were cognitively normal, 10 had mild cognitive impairment, and 2

Do entrepreneurs benefit post their entrepreneurial careers on re-entry into paid employment? An answer to this question provides a career value of engaging in an entrepreneurial career. Results have so far been inconclusive suggesting that we still do not know whether entrepreneurship pays or not. Using job matching as the main theoretical foundation, this study investigates how the returns from

Aims: To assess the prevalence and prevalence relative risk (PRR) of Type 1 diabetes mellitus (T1DM) and Type 2 diabetes mellitus (T2DM) among people with intellectual disabilities (ID) compared to the general population using a register-based cohort in Sweden. Methods: The study included 14,716 people with ID and 1226,955 people from the general population in Skåne, Sweden, on January 1st, 2014.

INTRODUCTION: Since the last two decades, there has been a dramatic rise in caesarean sections (CS) throughout the world. This increase has been seen even in Europe, where rates vary significantly from 17% in Northern Europe to 56% in the South. Although, CS can be a lifesaving intervention when medically necessary, non-essential CS are associated with short- and long-term complications for both t

Objective In systemic lupus erythematosus (SLE), disease activity and glucocorticoid (GC) exposure are known to contribute to irreversible organ damage. We aimed to examine the association between GC exposure and organ damage occurrence. Methods We conducted a literature search (PubMed (Medline), Embase and Cochrane January 1966-October 2021). We identified original longitudinal observational stud

Background/AimA randomized clinical trial with a starch- and sucrose-reduced diet (SSRD) in irritable bowel syndrome (IBS) patients has shown clear improvement of participants' symptoms. The present study aimed to explore the effects of the SSRD on the gut microbiota and circulating micro-RNA in relation to nutrient intake and gastrointestinal symptoms.MethodsIBS patients were randomized to a 4-we