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Tropomyosin-related kinase A (TrkA) receptor mediates the effects exerted by nerve growth factor on several subpopulations of neuronal cells. Ligand binding to TrkA induces receptor autophosphorylation on several tyrosine residues and the activation of signaling cascades. In this study, we describe a new site relevant for TrkA regulation, the tyrosine 701 (Y701), which is important for receptor tr
Dysregulation of autophagy has been observed in obesity and type 2 diabetes. Salt-inducible kinase 2 (SIK2), a member of the AMPK-related kinase family, is downregulated in adipocytes from obese or insulin resistant individuals and was previously demonstrated to regulate autophagy in cancer and normal cell lines. The aim of this study was thus to investigate a potential role of SIK2 in the regulat
Transforming growth factor-beta (TGF-beta) is involved in vascular formation through activin receptor-like kinase (ALK)1 and ALK5. ALK5, which is expressed ubiquitously, phosphorylates Smad2 and Smad3, whereas endothelial cell (EC)-specific ALK1 activates Smad1 and Smad5. Because ALK5 kinase activity is required for ALK1 to transduce TGF-beta signaling via Smad1/5 in ECs, ALK5 knockout (KO) mice w
Neuroblastoma and ganglioneuroma are neuroblastic tumors originating from the developing sympathetic peripheral nervous system. Ganglioneuromas are usually benign, while neuroblastomas have a variable prognosis and include very aggressive tumors. Examples exist of neuroblastomas regressing to ganglioneuromas and ganglioneuromas progressing to neuroblastomas. Little is known of the molecular differ
Activation of extracellular-signal-regulated kinase-1/2 (Erkl/2) by phosphorylation to p-Erkl/2, and proliferation of Schwann cells were investigated in the rat sciatic nerve by immunohistochemistry. Axotomy in vivo and culturing of nerve segments in vitro resulted in a rapid (30 min) increase of p-Erkl/2 in Schwann cells with peaks at 2 and 24 h. Proliferation measured by bromodeoxy uridine incor
Popular Abstract in Swedish Globala klimatförändringar, nationell säkerhet och ekonomisk stabilitet är alla starka drivkrafter för utveckling av nya drivmedel. Två intressanta alternativ är vätgas och metangas producerade från förnyelsebara råvaror. Detta kan göras i biologiska processer där bakterier omvandlar socker till vätgas eller metangas. Dessa processer måste dock utvecklas och förbättras A great deal of research is being carried out on the biological production of hydrogen and methane. However, little effort has been devoted to studying the technical and economic feasibility of these processes. The main objective of the work presented in this thesis was to perform techno-economic analyses to improve our understanding of the processes by identifying the bottlenecks, and to provide
Parkinson’s disease (PD) is currently the second most common neurodegenerative disorder (after Alzheimer’s disease). PD is diagnosed on its motor symptoms, which include akinesia, bradykinesia, rigidity, postural imbalance and resting tremor. It is well established that the motor symptoms develop due to lack of dopamine in the striatum. This is caused by progressive degeneration of dopaminergic ne
This study analyzes innovation activities in medium-technology sectors in Germany, Italy and Spain and checks whether cross-country similarities or differences prevail. The results have important implications for the Sectoral Systems of Innovation and the Distance-to-the-Frontier frameworks. While the Sectoral Systems of Innovation predicts the existence of technology-related similarities in innov
Data on net CO2 exchange from eight forests in Denmark, Sweden, Finland and Iceland were used to analyse which factors were controlling photosynthesis and respiration. The forests consisted of different species ranging in climatic condition from temperate to subarctic. Only well mixed conditions were analysed (u* > 0.3 m s(-1)). The parameters of a light response function showed strong seasonal va
In the midst of a global shift in world politics induced by the rise of emerging powers, the outdated and unequal international financial institutions (IFIs) that were set up after World War II are increasingly being challenged and scrutinized. International actors can use IFIs in numerous ways to enhance their position in the world system. For instance, they can be used as a vehicle to launder st
MILJÖVETENSKAP Preliminärt schema 181001 Kurs: Tillämpad Miljövetenskap Kursansvarig: Håkan Wallander Lärare: Håkan Wallander (HW), Radhlinah Aulin (RA), Per-Erik Isberg (PEI), Deniz Koca (DK), Johanna Alkan Olsson (JAO) Lokaler: Vitmossan, Ekologihuset, Sölvegatan 37, se karta över kurslokaler Litteratur: Studieteknik: Läs om studieverkstaden Studenträttigheter: Läs om dina rättigheter och skyldi
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mven14_2018x.pdf - 2026-07-12
https://www.lu.se/evenemang/eu-days-lund-2025 - 2026-07-12
Background Previous studies have indicated that vitamin K deficiency is common in non-bleeding critically ill patients with slightly prolonged prothrombin time-international normalized ratio (PT-INR). It has never been investigated thoroughly whether the administration of vitamin K to these patients could affect their PT-INR. Therefore, the aim of this registry study was to evaluate changes in PT-
