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Cumulative evidence in brains and cultured neurons of Alzheimer's disease (AD) transgenic mouse models, as well as in human postmortem AD brains, highlights that age-related increases in β-amyloid peptide (Aβ), particularly in endosomes near synapses, are involved in early synapse dysfunction. Our immunoelectron microscopy and high-resolution immunofluorescence microscopy studies show that this ea
To meet urgent needs for solving serious worldwide drug-resistance problems, a sensitive label-free capacitive sensor developed in our group was investigated as a tool to be applied in the field of antibiotic resistance genotyping, for instance the detection of ampicillin resistance gene (ampR). Proof-of-concept data demonstrated its detection sensitivity of pico-molar without any signal amplifica
Two short-lived isotopes 221U and 222U were produced as evaporation residues in the fusion reaction 50Ti+176Yb at the gas-filled recoil separator TASCA. An α decay with an energy of Eα=9.31(5) MeV and half-life T1/2=4.7(7) μs was attributed to 222U. The new isotope 221U was identified in α-decay chains starting with Eα=9.71(5) MeV and T1/2=0.66(14) μs leading to known daughters. Synthesis and
Recent studies indicate that the urokinase system could have an important role in atherogenesis and plaque rupture. The relationships among the soluble urokinase plasminogen activator receptor (suPAR), carotid plaque, and incidence of ischemic stroke and coronary artery disease (CAD) events were studied in a prospective cohort.
The importance of lake ecosystems for waterfowl remains a topic of debate. In order to assess how temporal variations in lake features, specifically shifts between alternative stable states, may interact with the waterfowl fauna, we performed a long-term (22 years) study of the shallow Lake Krankesjon, southern Sweden. Lower total numbers of waterfowl occurred during periods with low macrophyte co
Blogs offer a space where engineers can engage with public audiences about engineering topics, challenging and surpassing a deficit model of science communication. Communication that is adapted for a broad audience, discusses topics that are socially relevant, and facilitates participation and dialogue is more likely to be engaging. We examined 14 top engineering blogs to see how engineers present
Our paper traces the history and progressive development of environmental education and education for sustainable development (ESD) in Sweden and Denmark. Our main focus is on work in primary and lower secondary schools as part of a search for trends of international interest related to the conceptualisation and practice of environmental education and ESD in both countries, as well as the role and
Laibl, L., Fatka, O., Budil, P., Ahlberg, P., Szabad, M., Voka, V. & Kozak, V., 24.3.2015. The ontogeny of Ellipsocephalus (Trilobita) and systematic position of Ellipsocephalidae. Alcheringa 39, 477-487. ISSN 0311-5518.Well-preserved early holaspid stages of the Cambrian Series 3 trilobites Ellipsocephalus hoffi (Schlotheim, 1823) and Ellipsocephalus polytomus Linnarsson, 1877 have been disco
The potential machinability for Alloy 718 (Inconel 718) is examined in terms of five material characteristics considered to play a key role in the machinability: ductility (elongation to fracture), strain hardening (ultimate tensile strength over yield strength), thermal conductivity, yield strength and abrasiveness (amount of carbides). The material characteristics are simulated with the software
Increased efficiency and effectiveness in the product life cycle can be expected to result from extending the product development process to include the simultaneous development of the package. In this paper, three surveys performed in the Swedish mechanical, pharmaceutical and food industries are supplemented to describe the interest of such a concept in industry. This paper reveals that both the
Aims: To test if islet autoantibodies at diagnosis of type 1 diabetes (T1DM) and after 3-6 years with T1D predict residual beta-cell function (RBF) after 3-6 years with T1D. Methods: T1D children (n = 260, median age at diagnosis 9.4, range 0.9-14.7 years) were tested for GAD65, IA-2, ZnT8R, ZnT8W and ZnT8Q autoantibodies (A) at diagnosis, and 3-6 years after diagnosis when also fasting and stimul
A strict division between the formal economy and the informal economy cannot be made and every economic actor has in certain situations a propensity to engage in informal economic activities. The formal, as well as informal economy may lead to economic growth which is essential for a broad welfare policy, under which social benefits are categorized. A person's economic contribution to a state shou
With New Public Management came the idea that public organizations should be led by professional managers, rather than by professionals. This has been referred to as new managerialism. This article explores how new managerialism may affect professional autonomy in a public organization that enjoys a high – and constitutionally protected – degree of organizational autonomy. A framework distinguishi
In this paper, the controllability and admissibility of perturbed semigroup systems are studied, using tools from the theory of interpolation and Carleson measures. In addition, there are new results on the perturbation of Carleson measures and on the weighted interpolation of functions and their derivatives in Hardy spaces, which are of interest in their own right.
The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analy
This article provides an account of post-communist civil society in Latvia. Based on original survey data, the structure of civil society is analysed on both individual and organisational levels and cultural aspects are examined. The weakness of post-communist civil society found in much previous research is confirmed when measured on the individual level and in relation to some organisational asp
Using unique Swedish disclosure data from 2007 to 2012, this paper reports three important sets of findings with regard to the relationship between firms' voluntary disclosure, external financing and financial status. First, financially strong firms disclose more than weaker ones. Second, firms that obtain new financing (equity or debt) disclose more than firms that do not. Third, the association
The solution of the forward problem in fluorescence molecular imaging strongly influences the successful convergence of the fluorophore reconstruction. The most common approach to meeting this problem has been to apply the diffusion approximation. However, this model is a first-order angular approximation of the radiative transfer equation, and thus is subject to some well-known limitations. This
The random fluctuations of spins give rise to many interesting physical phenomena, such as the 'order-from-disorder' arising in frustrated magnets and unconventional Cooper pairing in magnetic superconductors. Here we show that the exchange of spin waves between extended topological defects, such as domain walls, can result in novel magnetic states. We report the discovery of an unusual incommensu
