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Introduction: Evidence-based clinical practice guidelines drive optimal patient care and facilitate access to high-quality treatment. Creating guidelines for rare diseases such as haemophilia, where evidence does not often come from randomized controlled trials but from non-randomized and well-designed observational studies and real-world data, is challenging. The methodology used for assessing av

The book is a comparative study in the status of international human rights norms in the domestic law of all the Nordic countries and the three Baltic states: Estonia, Latvia and Lithuania. An amazingly rapid development towards direct applicability of international human rights treaties has taken place in recent years in all the countries in question. This book provides in-depth analysis of the s

Azurocidin is a multifunctional endotoxin-binding serine protease homolog synthesized during the promyelocytic stage of neutrophil development. To characterize the biosynthesis and processing of azurocidin, cDNA encoding human preproazurocidin was stably transfected to the rat basophilic leukemia cell line RBL-1 and the murine myeloblast-like cell line 32D cl3; cell lines previously utilized to st

2-amino-2-methyl-1-propanol (AMP) in dimethyl sulfoxide (DMSO) is a precipitating non-aqueous amine technology that can potentially lower the energy demand during CO2 removal from industrial flue gases compared to aqueous amine technologies. However, DMSO is hygroscopic and has a high possibility of absorbing water from humid flue gases, which can affect the physical properties of the system,

We have previously demonstrated that the intracellular, non-GPI anchored CD59 isoforms IRIS-1 and IRIS-2 (Isoforms Rescuing Insulin Secretion 1 and 2) are necessary for insulin secretion from pancreatic β-cells. While investigating their expression across human tissues, we identified IRIS-1 and IRIS-2 mRNA in the human brain, though their protein expression and function remained unclear. This stud

The paper concerns a historical shift in the semiotic interpretation of financial data and how this shaped the imagination of the market. The investigation centres on the emergence of two systems of financial foresight, technical and fundamental analysis. It is demonstrated how both systems were synthesised around the codification of certain pieces of data as semiotic windows to the future which t

This editorial introduces the Special Section on 'The Borders Within: Socio-Economic Rights and Non-discrimination in EU Law' whose purpose is to provide a comprehensive and non-fragmented understanding of socio-economic rights, the right to non-discrimination and their meaning for welfare in EU Member States. Under EU law the boundaries between national socio-economic policies and the enjoyment o

Research on the rhythmic communication (RC) of nonhuman animals is undergoing a period of great effervescence and expansion. Here, we synthesize this rapidly growing literature with the aim of mapping RC forms and usage contexts in an unprecedented diversity of taxa, spanning insects, fish, frogs, birds and mammals. We see this as a first large-scale effort toward charting the functional and struc

Health is multifaceted, with divergent interpretations in diverse cultures and groups of individuals. The ways individuals understand health might aid in developing future interventions. There is scant knowledge on how adolescents with depression conceptualise health. A descriptive qualitative design with a phenomenographic approach was used to describe the different ways adolescents with depressi

Introduction: The pulmonary oxygen uptake is reduced during apnea, compared to eupneic baseline, preserving the pulmonary oxygen store. This study elucidates the time course for this reduction, comparing it to the time course for apnea-induced cardiovascular responses. Methods and results: Experiments involved two groups, performing apneas during rest, both without and with cold-water face immersi

Absolute environmental sustainability assessments quantify the environmental impacts of human activities in relation to ecological carrying capacities. Such assessments necessitate the application of sharing principles to allocate shares of carrying capacity to actors and activities at different scales, including products, companies, sectors, and countries. This can help decision-makers set target

BACKGROUND: The impact of the environmentally sustainable EAT-Lancet diet on dementia risk remains poorly understood. The aim was to investigate associations between the EAT-Lancet diet and incident dementia.METHODS: Associations of the EAT-Lancet diet with all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD) were investigated among 25,898 participants from the Malmö Diet and