Filetype
Ribonucleotide reductases (RNRs) catalyze all new production in nature of deoxyribonucleotides for DNA synthesis by reducing the corresponding ribonucleotides. The reaction involves the action of a radical that is produced differently for different classes of the enzyme. Class I enzymes, which are present in eukaryotes and microorganisms, use an iron center to produce a stable tyrosyl radical that
The mechanisms of coronavirus disease-2019 (COVID-19)–related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and
Iraqi diaspora mobilization and the future development of Iraq – authored by Dr. Oula Kadhum, explores Iraqi diaspora mobilization before and after the 2003 invasion and fall of the regime of Saddam Hussein. It looks at the ways members of the diaspora sought to help in the rebuilding of their country of origin, at both the elite and grassroots levels, as well as investigating changes over time. I
The future is robotic. Already we are seeing how society is changing with self-driving cars and robots at hospitals and schools. The huge potential of autonomous systems (AS) is highly discussed. What is not highly discussed, and rarely even acknowledged, is the key role trust plays in realizing these benefits. No common way of defining, testing, or measuring it exists. I argue that this lack of
Previous research suggests that parties in contractual relationships adopt a governance structure that economizes on transaction costs, and then over time learn to govern the contractual relationships in a more efficient manner by incrementally aligning contractual terms with transaction attributes based on new experiences made in the relationship. This implies that learning to contract and the de
Flerovium (Fl, element 114) is the heaviest element chemically studied so far. To date, its interaction with gold was investigated in two gas-solid chromatography experiments, which reported two different types of interaction, however, each based on the level of a few registered atoms only. Whereas noble-gas-like properties were suggested from the first experiment, the second one pointed at a vola
The purpose of this study is to apply Hambrick and Finkelstein's (1987) framework of managerial discretion to the field of capital budgeting techniques (CBT). This study uses a qualitative method based on semi-structured interviews with 12 CFOs in Swedish high-growth small and medium-sized (SMEs) firms. The findings indicate that the choice of CBTs is largely enabled by individual forces and mainl
The agricultural sector has a critical role in creating social and environmental value of natural resources in addition to its traditional role of creating economic value by supplying food to the ever-increasing world population. In fulfilling this dual role, the agricultural sector often faces competing pressures: to operate financially profitable businesses and to create, maintain, and benefit f
What makes people affectively polarized? Affective polarization is based on the idea that partisanship can be a social identity leading to polarization in the form of intergroup distancing between the own party and the other parties. In this study, we argue that perceived threats from an outgroup can spur affective polarization. To investigate this, we use the issue of immigration, often framed as
The Forward Physics Facility (FPF) is a proposal to create a cavern with the space and infrastructure to support a suite of far-forward experiments at the Large Hadron Collider during the High Luminosity era. Located along the beam collision axis and shielded from the interaction point by at least 100 m of concrete and rock, the FPF will house experiments that will detect particles outside the acc
INTRODUCTION: We studied whether adding percent free prostate-specific antigen (%fPSA) to total PSA improves prediction of clinically significant prostate cancer (csPCa) and fatal PCa.METHODS: 6727 men within the intervention arm of the Prostate, Lung, Colorectal and Ovarian Trial had baseline %fPSA. Of this cohort, 475 had csPCa and 98 had fatal PCa. Cumulative incidence and Cox analyses were con
The exchange-correlation hole and potential of the homogeneous electron gas have been investigated within the random-phase approximation, employing the plasmon-pole approximation for the linear density response function. The angular dependence as well as the time dependence of the exchange-correlation hole are illustrated for a Wigner-Seitz radius rs=4 (atomic unit). It is found that there is a su
Theorists of the transnational cleavage, defined as a political reaction against European integration and immigration, also regularly conceptualise international trade preferences as a component of this contemporary societal divide. Yet empirical analyses of this cleavage focus on the former two topics, while trade and the transnational cleavage has not been systematically investigated. Making use
