Filetype
Amyloid diseases are defined by tissue deposition of insoluble, fibrillar beta-sheet polymers of specific proteins, but it appears that toxic oligomeric species rather than the fibrils are the main cause of tissue degeneration. Many proteins can form amyloid-like fibrils in vitro, but only similar to 30 proteins have been found to cause mammalian amyloid disease, suggesting that physiological mech
After the successful completion of the Human Genome Project, the Human Proteome Organization has recently officially launched a global Human Proteome Project (HPP), which is designed to map the entire human protein set. Given the lack of protein-level evidence for about 30% of the estimated 20,300 protein-coding genes, a systematic global effort will be necessary to achieve this goal with respect
OBJECTIVES: The aim was to gather information regarding what students consider important for their motivation to attain knowledge, in order to shape courses that foster this motivation. METHOD: A qualitative design comprising focus groups including 31 nursing and medical students for interviews, semi-structured questions, and content analysis was utilized. RESULT: The students thought it was impor
The scientific objectives of the Cain mission cover areas of galactic structure and evolution, stellar astrophysics, exoplanets, solar system physics, and fundamental physics. Astrometrically, its main contribution will be the determination of millions of absolute stellar parallaxes and the establishment of a very accurate, dense and faint non-rotating optical reference frame. With a planned launc
The term ‘storytelling’ has a long history of prominence in descriptive and prescriptive talk about jazz improvisation. The main aim of this article is to point out that the ways in which jazz musicians themselves employ the ‘storytelling’ metaphor with reference to jazz improvisation display several important perspectives on perennial and fundamental prob- lems in the field of musical narrativity
As Cooren and Sandler note in their paper, communication studies has largely received Bakhtin as a theorist of dialogue, but such a framing limits his potential contributions to our thinking. They argue that when we seek to understand the communicative constitution of reality, Bakhtin's work can lead us in novel and fruitful directions. I find their claims compelling, and thus this response is mor
Trismus, a well-known sequelae after treatment of head and neck cancer, decreases a patient's oral function and quality of life. The main objectives of this study were to: 1) investigate the long-term prevalence of radiation-induced trismus in patients treated for head and neck cancer according to two different fractionation schedules; and 2) model a dose-response relationship for trismus. Materia
To better understand how silkmoth cocoons maintain the correct internal moisture levels for successful pupation, we examined cocoons from the long-domesticated mulberry silkmoth Bombyx mori as well as from two wild silkmoth species, Antheraea pernyi and Philosamia cynthia ricini. We determined fluid-independent values for the porosity, tortuosity and permeability of the inner and outer surfaces of
Evolutionary divergence in the coloration of toxic prey is expected when geographic variation in predator composition and behavior favours shifts in prey conspicuousness. A fundamental prediction of predator-driven colour divergence is that the local coloration should experience lower predation risk than novel prey phenotypes. The dorsal coloration of the granular poison frog varies gradually from
Pancrustacea (Hexapoda plus Crustacea) display an enormous diversity of eye designs, including multiple types of compound eyes and single-chambered eyes, often with color vision and/or polarization vision. Although the eyes of some pancrustaceans are well-studied, there is still much to learn about the evolutionary paths to this amazing visual diversity. Here, we examine the evolutionary history o
The mineral dust cycle responds to climate variations and plays an important role in the climate system by affecting the radiative balance of the atmosphere and modifying biogeochemistry. Polar ice cores provide unique information about deposition of aeolian dust particles transported over long distances. These cores are a palaeoclimate proxy archive of climate variability thousands of years ago.
Objective: To assess the responsiveness of the Intermittent and Constant Osteoarthritis Pain (ICOAP) measure, Hip Disability and Osteoarthritis Outcome Score Physical Function Short Form (HOOS-PS), and the Knee Disability and Osteoarthritis Outcome Score Physical Function Short Form (KOOS-PS) in a pharmacological trial. Methods: Data were obtained from a randomized double-blind trial comparing nap
Hjalmarsson (2010) considers an OLS-based estimator of predictive panel regressions that is argued to be mixed normal under very general conditions. In a recent paper, Westerlund et al. (2016) show that while consistent, the estimator is generally not mixed normal, which invalidates standard normal and chi-squared inference. The purpose of the present paper is to study the consequences of this the
This paper investigates financialisation of built environments in Stockholmand Copenhagen, especially within the sphere of housing. It presents empiricalanalyses of processes of financialisation of built environments in the two cities, and how these processes relate to urban politics and governance. The case studies include analyses of how financialisation of built environments and associated shif
The surface core-level shifts of the Al(100) and Al(111) surfaces have been measured by high-resolution photoelectron spectroscopy. For the Al(100) surface we obtain a value of (-965) meV. This value is in excellent agreement with a recent ab initio calculation by Feibelman. The surface core-level shift of the Al(111) surface is found to be close to zero, and an upper limit of 15 meV is obtained.
