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Class II antigens of the major histocompatibility complex (MHC) consist of two glycosylated, membrane-integrated polypeptide chains1. These cell surface-expressed molecules are involved in several immunobiological events involving cell-cell interactions2,3, most of which seem to require that genetically identical class II antigens, or other molecules controlled by the same region of the MHC, are e
The Galactic Center is one of the most dense stellar environments in the Galaxy and is considered to be a plausible place to harbor many neutron stars. In this brief review, we summarize observational efforts in search of neutron stars within a few degrees about the Galactic Center. Up to 10% of Galactic neutron stars may reside in this central region and it is possible that more than a thousand n
Breast cancer is the most common cancer among women in the Western world. In Sweden, 1 in 9 women will be diagnosed during their lifetime, amounting to >8,000 new breast cancers per year. Each year around 1,400 patients die from their disease. A comprehensive report entitled "highlighted several areas in need of more research", including how weight, alcohol consumption, smoking, host metabolism an
Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitor cells. Two subsets, plasmacytoid DCs (pDCs) and myeloid DCs (mDCs), have been identified. Little is known regarding DC levels in bone marrow of patients with acute myeloid leukaemia (AML) before and after chemotherapy. We investigated relative pDC and mDC levels in bone marrow from 37 hospital controls and 60 patients
Collections of sayings of the desert fathers and mothers are extant in manuscripts in many languages and are organized differently. They are ‘fixed-content miscellanies’ (FCM): they include material that belongs to the same genre, but is variable both when it comes to appearance and order. Distance measurement methods are particularly suitable for large text traditions including variable content i
Human PBL from vaccinated healthy blood donors, which was transplanted i.p. into mice with severe combined immunodeficiency (SCID), exhibited an Ag-dependent humoral Ir against tetanus toxoid. This Ir was dose dependent and was completely abrogated by immunizing with large amounts of Ag, suggesting a high dose tolerization of the B cells. A dose-dependent selection of specific, high affinity B clo
While the economic impact of China’s ‘Belt and Road’ Initiative (BRI) in Sri Lanka has been closely monitored in recent years, few studies have focused on the role of China’s Buddhist narratives in furthering the countries’ interests. By analyzing the Buddhist strategic narratives used in official Chinese and Sri Lankan statements, this article argues that under the BRI’s ‘people-to-people’ bonds,
Oral direct inhibitors (ODIs) of thrombin and factor Xa are now approved as anticoagulant drugs. The first two drugs to complete phase III clinical trials for thromboprophylaxis in orthopaedic surgery and treatment of patients with atrial fibrillation or venous thromboembolism were dabigatran and rivaroxaban. These small molecules are given at fixed dose with no requirement for monitoring as pharm
In The Act of Documenting (2016), Winston, Vanstone and Chi connect production studies with reception studies in docmedia. This work signals how the act of documenting, a performative practice within the media industries, is intrinsically connected with the act of watching, a performative practice within cultures of viewing. There are challenges in conducting documentary audience research, in part
Nucleotide-binding and oligomerization domain (NOD) -like receptors (NLRs) and retinoic acid-inducible gene (RIG) -like receptors (RLRs) are recently discovered cytosolic pattern-recognition receptors sensing mainly bacterial components and viral RNA, respectively. Their importance in various cells and disorders is becoming better understood, but their role in human tonsil-derived T lymphocytes re
