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Alpha-ketoglutarate decreases serum levels of C-terminal cross-linking telopeptide of type I collagen (CTX) in postmenopausal women with osteopenia: Six-month study

Several studies have shown that alpha-ketoglutaric acid (AKG) increases serum levels of proline and has beneficial effects on skeletal development. We studied the effect of alpha-ketoglutaric (AKG) acid calcium salt (6 g AKG and 1,68 Ca/day) or calcium alone (1.68 Ca/day) on serum C-terminal cross-linked telopeptide of type I collagen (CTX) and osteocalcin (OC), as well as lumbar spine bone minera

New scale factors for harmonic vibrational frequencies using the B3LYP density functional method with the triple-xi basis set 6-311+G(d,p)

We have calculated optimal frequency scaling factors for the B3LYP/ 6-311+G(d,p) method for fundamental vibrational frequencies on the basis of a set of 125 molecules. Using the new scaling factor, the vibrational frequencies calculated with the triple-zeta basis set 6-311+G(d,p) give significantly better accuracy than those calculated with the double-zeta 6-31G(d) basis set. Scale factors were al

How to compensate the irreplaceable? A socio-legal research project within victimology about the relation between formal and informal norms

As an ambition to stress the construction of an external and an internal dimension within law I have chosen to study the non-pecuniary damages to victims of crime. The foundation for these damages came from the deep structure of law about the idea that the right to integrity of the human body and soul are one of the corner- stones in the state governed by law. But when it comes to estimating the a

Kontinuerliga tvåfraktionsinsamlare för övervakning av partikulära luftföroreningar i arbetsmiljö

Rapporten beskriver prototyper av kontinuerliga tvåfraktionsinsamlare för övervakning av partikulära luftföroreningar i arbetsmiljö som har konstruerats. En prototyp är personburen och ger möjligheter till insamling av två partikelstorleksfraktioner i 18 diskreta intervall. PIXE-metoden (analys med partikelinducerad röntgenstrålning) används för multielementanalys av de erhållna proven. Även med m

Avian neural crest cell migration is diversely regulated by the two major hyaluronan-binding proteoglycans PG-M/versican and aggrecan

It has been proposed that hyaluronan-binding proteoglycans play an important role as guiding cues during neural crest (NC) cell migration, but their precise function has not been elucidated. In this study, we examine the distribution, structure and putative role of the two major hyaluronan-binding proteoglycans, PG-M/versicans and aggrecan, during the course of avian NC development. PG-M/versicans

Telomerase activation as a possible mechanism of action for psychopharmacological interventions.

Originally studied in relation to aging and cancer research, telomerase is now also investigated in relation to psychiatric disorders and treatments. Based on emerging clinical and preclinical data, we hypothesise that telomerase activation could represent a novel element mediating the mechanism of action of certain psychopharmacological interventions (e.g. antidepressants, lithium and antipsychot

Nonendocrine Cancers Associated with Benign and Malignant Parathyroid Tumors.

Context: There are limited reliable epidemiological data concerning whether individuals with benign/malignant parathyroid tumor are at an elevated risk of developing nonendocrine malignancies or vice versa. Objective: The objective of the study was to quantify these risks, especially risk of parathyroid tumors after other cancers. Design: This was a population-based retrospective cohort study. Par

Users’ experience of a virtual reality architectural model compared with users’ experience of the completed building

This research investigated how the employees of a company experienced a VR-model of an office building that was to be their future work place and how that VR-experience com¬pared with the employees’ experience of the completed building. About two years after the VR-showings the building was completed and the staff had moved into the building. The results for the employees who saw the VR-presentati

Generative learning management : A dual-role model for creativity in organizations

Popular Abstract in Swedish Syftet med avhandlingen var att utveckla en modell för ledarskap som påverkar målorienterad social kreativitet i organisationer. Modellen, på engelska benämnd Generative learning management, har två dimensioner: målstyrning genom tilldelning och decentralisering av beslutsrätten över strategiutveckling för att nå målen i analogi med parallell distribution. I rent praktiA main purpose of this thesis was to develop a model of leadership style named Generative Learning Management (GLM), thought to influence goal-oriented interpersonal creativity in organizations, and to test this model. Creativity is a complex consisting of both novelty and usefulness and it is a general mental ability that is determined by the interplay between different regions in a normally func

The glutamic acid decarboxylase 65 immunoglobulin G subclass profile differs between adult-onset type 1 diabetes and latent autoimmune diabetes in adults (LADA) up to 3 years after clinical onset.

Autoantibodies against glutamic acid decarboxylase 65 (GADA) are found frequently in patients with autoimmune diabetes. Immunoglobulin (Ig)G(1) is the most frequent subclass among the GADA IgG subclasses. IgG(4) is a more common subclass in latent autoimmune diabetes in adults (LADA) at clinical onset compared to type 1 diabetes. The aim of this work was to study the different GADA-IgG subclass pr

Formation of the bicoid morphogen gradient: an mRNA gradient dictates the protein gradient

The Bicoid (Bcd) protein gradient is generally believed to be established in pre-blastoderm Drosophila embryos by the diffusion of Bcd protein after translation of maternal mRNA, which serves as a strictly localized source of Bcd at the anterior pole. However, we previously published evidence that the Bcd gradient is preceded by a bcd mRNA gradient. Here, we have revisited and extended this observ

Adjuvant oil induces waves of arthritogenic lymph node cells prior to arthritis onset.

A single intradermal injection of the adjuvant-oil squalene induces T cell mediated arthritis in DA rats. The chain of events leading from nonspecific provocation of the immune system to arthritis is largely unknown. Previous studies have demonstrated that lymph node (LN) cells are of pathogenic importance, i.e. cells from LNs draining the injection site can transfer arthritis to naïve DA rats. Re

Determination of glutamic acid decarboxylase antibodies (GADA) IgG subclasses - comparison of three immunoprecipitation assays (IPAs)

IgG subclasses of glutamic acid decarboxylase (GAD(65)) antibodies (GADA) may reflect the immunological state in the pancreas of GADA-positive patients with autoimmune diabetes. The use of biotin-conjugated antibodies and streptavidin Sepharose are used commonly in immunoprecipitation assays (IPA) based on (125)I- or (35)S-labelled antigens to capture IgG subclasses directed against IA-2 or GAD(65