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Development of a Multiparametric Voxel-Based Magnetic Resonance Imaging Biomarker for Early Cancer Therapeutic Response Assessment.

Quantitative magnetic resonance imaging (MRI)-based biomarkers, which capture physiological and functional tumor processes, were evaluated as imaging surrogates of early tumor response following chemoradiotherapy in glioma patients. A multiparametric extension of a voxel-based analysis, referred as the parametric response map (PRM), was applied to quantitative MRI maps to test the predictive poten

From Husserl to Ihde and Beyond - Some Evolutionary Lines in Contemporary Philosophy of Technology

My paper is the introduction to my next book in the series 'The humanist as Engineer'. In my work, I have been deeply influenced by Don Ihde and his postphenomenological approach to the philosophy of technology. As Ihde’s postphenomenology, my approach is historical and differs strongly from the 'pure' phenomenological approach in spite of being connected with it through many common references. In

Product Standards for Multiple-Function Products in Product Policy

Emergence of multiple-function products (MFPs) poses a variety of challenges and risks for achieving sustainable consumption and production as well as fair consumer society and universal design. We overviewed MFPs from these viewpoints and then, focusing on product standard as a means to create mechanisms to reduce environmental loads from products, elucidated advantages and limitation of five app

Material Selection in Industrial Design Education : A literature review

This study reviews literature on the aspects of material selection within the field of industrial design education, specifically focusing on existing material selection tools and guidelines used in industrial design education. The growing number of materials available today has created a large variety of options for industrial designers, which they are ill-equipped to handle. A key reason behind t

Analysing vegetation changes in the Sahel using sensor data from Landsat and NOAA

The semi-arid Sahel zone of Africa has suffered several periods of severe drought since about 1950. We have analyzed AVHRR Normalized Difference Vegetation Index (NDVI) over the Sahel for the period 1982-2002, and found extensive areas of increasing NDVI. To verify these changes we have analyzed Landsat TM and ETM+ scenes from 1984-1986 and 1999-2001 for areas in the Sudan, Central African Republi

The eIF2α kinase heme-regulated inhibitor protects the host from infection by regulating intracellular pathogen trafficking

The host employs both cell-autonomous and system-level responses to limit pathogen replication in the initial stages of infection. Previously, we reported that the eukaryotic initiation factor 2α (eIF2α) kinases heme-regulated inhibitor (HRI) and protein kinase R (PKR) control distinct cellular and immune-related activities in response to diverse bacterial pathogens. Specifically for Listeria mono

Generation of an induced pluripotent stem cell line (CSC-32) from a patient with Parkinson's disease carrying a heterozygous variation p.A53T in the SNCA gene

Here, we describe the generation of an induced pluripotent stem cell (iPSC) line, from a male patient diagnosed with Parkinson's disease (PD). The patient carries a heterozygous variation p.A53T in the SNCA gene. Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver OCT3/4, SOX2, c-MYC and KLF4 factors. The generated iPSC line (CSC-32) preserved the mutati

Writing in English at University : A Guide for Second Language Writers

Writing is a central activity at university. Writing in English at University: A Guide for Second Language Writers is a textbook designed to accompany the MOOC Writing in English at University. It can also be used as a stand-alone handbook, with links to online resources, such as instructional videos on key aspects of academic writing provided throughout.Just like the MOOC, this textbook targets u

Neurofilament light chain on intensive care admission is an independent predictor of mortality in COVID-19 : a prospective multicenter study

BACKGROUND: Neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and total-tau protein (tau) are novel blood biomarkers of neurological injury, and may be used to predict outcomes in critical COVID-19.METHODS: A prospective multicentre cohort study of 117 consecutive and critically ill COVID-19 patients in six intensive care units (ICUs) in southern Sweden between May and Novem

Safeguarding Food Industry : Understanding Cyberthreats and Ensuring Cybersecurity

The food industry stands as one of the most vital manufacturing sectors globally, with an ever-increasing reliance on digitalization and technology-driven processes. However, this advancement comes with an inherent risk of cyberattacks, encompassing data breaches and system disruptions, which can severely impact production and disrupt the entire food supply chain. Consequently, such cyberthreats c

Gut Micro- and Mycobiota in Preeclampsia : Bacterial Composition Differences Suggest Role in Pathophysiology

Preeclampsia is a severe pregnancy-related inflammatory disease without an effective treatment. The pathophysiology remains partly unknown. However, an increased inflammatory response and oxidative stress are part of the maternal systemic reaction. Recent data have suggested that dysbiosis of the gut microbiome plays a role in preeclampsia as well as other inflammatory diseases. However, dysbiosis

Self-reported quality of life before, during, and after pregnancy in women with CHD

Background:Adults with CHD are a growing patient group and childbirth is a relatively new phenomenon. EQ-5D is commonly used to measure health-related quality of life. We sought to investigate EQ-5D status before, during, and after pregnancy in women with CHD.Methods:We identified 128 pregnancies in 86 CHD women giving birth in Skåne County during 2009–2021. Repeated measures ANOVA was performed t