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The Wee1 cell cycle checkpoint kinase prevents premature mitotic entry by inhibiting cyclin-dependent kinases. Chemical inhibitors of Wee1 are currently being tested clinically as targeted anticancer drugs. Wee1 inhibition is thought to be preferentially cytotoxic in p53-defective cancer cells. However, TP53 mutant cancers do not respond consistently to Wee1 inhibitor treatment, indicating the exi

SummaryThe human pathogen Streptococcus pyogenes (GAS) causes both superficial infections, such as strep throat, and invasive infections, such as necrotizing fasciitis, and is responsible for about half a million deaths each year. The number of GAS infections have increased since the 1980’s, due to the emergence of a M1T1 strain that has become widely disseminated. Increased expression of Streptol

This thesis aims to analyze how identity and potential ontological insecurity are expressed in the Islamic State’s narrative and how this may explain the use of suicide attacks. This is done by analyzing the language in the Islamic State’s official magazines between 2014 to 2017 through a theoretical lens of ontological security. The theory of ontological security centers around the threat to an o

https://www.ark.lu.se/media/utbildning/dokument/kurser/ARKA12/20131/Johnny_Nyman_.pdf - 2026-06-02

Den här studien undersöker i vilken utsträckning som Northern Ireland Women’s Coalition (NIWC) bidrog till att göra genus centralt i fredsprocessen i Nordirland under slutet av 1990-talet, samt hur teorin gender centrality av Fionnuala Ní Aoláin kan interpreta fallet. Utgångspunkten i studien är kvinnors historiska exkludering från den Nordirländska politiken och NIWC:s unika roll som kvinnor i fr

Remanufacturing is a key strategy in the circular economy, enabling substantial product value retention. However, inconsistent definitions across standards and legislation hinder global trade, core recovery and market acceptance. This study examines how remanufacturing is defined in laws and standards, and how these definitions impact industry practices. Through a literature review of key existing

0080.tif Self-Determination Theory and the Facilitation of Intrinsic Motivation, Social Development, and Well-Being Richard M. Ryan and Edward L. Deci University of Rochester Human beings can be proactive and engaged or, alterna- tively, passive and alienated, largely as a function of the social conditions in which they develop and function. Ac- cordingly, research guided by self-determination the

https://www.saco.se/globalassets/lokala-akademikerforeningar/kommun-och-region/goteborgs-stad/dokument/facklig-foretradare/sveriges-skolledares-dokument/self-determination-theory-and-the-facilitation-of-intrinsic-motivation-social-development-and-well-being.pdf - 2026-06-02

A key question in Huntington's disease (HD) is what underlies the early cognitive deficits that precede the motor symptoms and the characteristic neuronal death observed in HD. The mechanisms underlying cognitive symptoms in HD remain unknown. Postmortem HD brain and animal model studies demonstrate pathologies in dendritic spines and abnormal synaptic plasticity before motor symptoms and neurodeg

Sore throat is common in primary healthcare. Aetiological studies have focused on the presence of a limited number of pathogens. The aim of the present study was to investigate the presence of a wide range of bacteria and viruses, including Fusobacterium necrophorum, in patients with pharyngotonsillitis and in asymptomatic controls. A prospective case control study was performed in primary healthc

MicroRNAs (miRNAs) have been implicated in regulating multiple processes during brain development in various species. However, the function of miRNAs in human brain development remains largely unexplored. Here, we provide a comprehensive analysis of miRNA expression of regionalized neural progenitor cells derived from human embryonic stem cells and human foetal brain. We found miR-92b-3p and miR-1

Affinity proteomics, represented by antibody arrays, is a multiplex technology for high-throughput protein expression profiling of crude proteomes in a highly specific, sensitive, and miniaturized manner. The antibodies are individually deposited in an ordered pattern, an array, onto a solid support. Next, the sample is added, and any specifically bound proteins are detected and quantified using m

TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the hig