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α-CGRP 8-37 is a peptide fragment of calcitonin gene-related peptide and is commonly used as a CGRP antagonist in pharmacological research. CGRP signaling has been discussed in relation to neuroimmune mechanisms in psoriasis, but a practical development of α-CGRP 8-37 requires analytical methods and formulation strategies that can handle peptide instability, adsorption, and matrix effects. The aim
This thesis investigates the design and evaluation of Large Language Model (LLM) agent assistants for industrial maintenance, developed in cooperation with SSAB. The study focuses on identifying what combinations of tools and architectures best serve the needs of maintenance technicians, with an emphasis on practical usability and factual correctness. Multiple agents were developed and compared,
Cybersecurity has never been more relevant than it is today, as attacks become increasingly sophisticated. To keep devices safe from threats, a new type of smart firewall has become an active area of research. This type of firewall can dynami- cally configure itself based on incoming network traffic using reinforcement learn- ing. This research has shown promising results; however, its impact on r
Non-terrestrial networks (NTNs) are expected to become an important component of future sixth-generation (6G) wireless systems by extending broadband coverage to remote, maritime, aerial, and underserved areas. Among different NTN platforms, low Earth orbit (LEO) satellite constellations are particularly attractive due to their lower propagation delay compared with geostationary systems. However,
Traditional football analytics largely evaluates players through on-ball events such as shots, passes and dribbles, leaving the much longer periods of off-ball play poorly measured. This thesis develops a spatial framework for evaluating individual player contributions in crossing situations, where a cross is defined as an aerial or driven delivery from a wide area into the central penalty zone. T
Direct-to-Device (D2D) communication in Non-Terrestrial Networks (NTNs) enables smartphones to connect directly to satellites, extending wireless coverage beyond terrestrial networks. This thesis presents the design of a smartphone antenna optimized for NTN operation, followed by a link budget analysis and Electromagnetic Field (EMF) exposure assessment. The proposed solution is a dual-band circu
Hirshfeld atom refinement (HAR) provides a more realistic interpretation of crystallographic data than the standard independent atom model (IAM) by using aspherical atomic form factors derived from quantum mechanical (QM) calculations. With this aspherical description, it is possible to obtain improved atomic positions, atomic displacement parameters and correct bond lengths even for hydrogen atom
This article is based on anthropological fieldwork undertaken at two elite universities in Beijing. It addresses the paradoxical situation of the many instances of suicide among Chinese elite university students in Beijing, which constitute a public secret. The pressure of education weighs heavily on the shoulders of China’s only child in each family, known as the generation of little emperors and
PurposeTürkiye ranks among the highest in antibiotic consumption within OECD countries and faces growing challenges from multidrug-resistant uropathogens. Nationwide, resistance-guided treatment data remain scarce. The main objective of this work is to provide a comprehensive nationwide data on antibiotic resistance patterns among uropathogens to guide treatment options in urinary tract infections
For the Inner Tracking System 3 (ITS3) upgrade, the ALICE experiment at CERN requires monolithic active pixel sensors of dimensions up to 97 mm×266 mm, occupying a large fraction of a 300 mm wafer. To manufacture such a wafer-scale device, larger than the single design reticle size, stitching is employed. The MOnolithic Stitched Sensor (MOSS) is a prototype silicon pixel sensor of 14 mm×259 mm siz
Water management is a critical factor for the performance and reliability of polymer electrolyte fuel cells (PEFCs) operating as energy generation systems. Inadequate operating conditions may lead to non-uniform water distribution, resulting in membrane dehydration or flooding of porous media, both of which adversely affect cell operation. In this work, a two-dimensional reduced-order model is dev
Musculoskeletal health is essential to health, well-being, and independence across the life course. Musculoskeletal conditions including inflammatory joint diseases, osteoarthritis, back pain, osteoporosis, and fragility fractures are among the greatest causes of disability globally imposing a major burden on health and social care and economic impact also through lost productivity. Despite effect
BACKGROUND: The aim was to improve the realism of patient models for Monte-Carlo based evaluation of image-based quantification of tumour volume and activity in [68Ga]Ga-DOTA-TOC PET and [177Lu]Lu-DOTA-TATE SPECT images.METHODS: Three phantoms from the XCAT population were used as basis. Tumour structures were obtained from segmentation of patient 68Ga-PET images and positioned at relevant positio
Evaluating the repellency of essential oils against Tetranychus urticae requires robust methodologies to detect time-dependent changes in their efficacy, due to differential efficacy, volatility, and sustained effectiveness. This study introduces the Pole-dance bioassay, a novel no-choice method optimized for high-throughput screening of time-dependent repellency, demonstrated through tests on twe
Lime-cement mixing is a method used for ground improvement of clay soils. Before mixing at a field site, laboratory samples are prepared and tested to decide the amount of lime-cement binder needed to reach the desired material strength. Strength measurements are not possible before a sample hardens, and the test process to predict final strength takes 30 days. Resistivity measurements are possibl
Geographical Information Systems (GISs) have shown to be of great help in the work at contaminated sites. Today there is an increase in the development of 3D modeling in many fields. However, to combine the advantage working with spatial data in a GIS and 3D modeling for subsurface soil data is limited. In this study, the possibilities of interpolating volumes of soil contamination in 3D were inve
