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We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer's disease. We sort existing mode
BACKGROUND: Lateral ankle sprain (LAS) is a common and burdensome injury. However, the quality of its management is scant. Nowadays, physiotherapy management of musculoskeletal diseases seems to be generally not based on research evidence. Studies that investigated the knowledge-to-practice gap in LAS management are yet to be carried out. Therefore, this research investigated physiotherapists' kno
Nominal classification is a robust feature in many Amazonian languages, and aspects of these systems offer significant challenges to our broader conception of the phenomenon. Yet a clear characterization of Amazonian classification systems must be firmly grounded in detailed descriptive analysis on one hand, and in a principled definition of classification as a typological category on the other –
The paper Pendulum: the partial and global approach combines a historic introduction to the theoretical treatment of pendulum motion with presentation of data from measurements on a single pendulum. This comment focuses on the presentation and analysis of experimental data, and how the use of dimensionless variables in graphs would make use of the mathematical properties, placing the single measur
Objectives. To design protocols for specific and quantitative immunohistochemical detection of human kallikrein 2 (hK2) using lanthanide chelate-labeled monoclonal antibodies (Mabs) and time-resolved fluorescence imaging. Methods. Anti-prostate-specific antigen (PSA) Mabs were tested in microtiterplate assays for their ability to prevent PSA from cross-reacting with the anti-hK2 Mab 6H10. Europium
Aural transposition sits at a crossroads between being a tool for practice and creating work, and being a tool that illuminates aspects of another entity. In day-to-day music practice, transposition can be an age-old tool for learning material, or a multi-layered exploration of an object or place. Transposition can also be a means of recreating places, real or imagined, through the transposition o
The Cherenkov Telescope Array (CTA) is a next generation ground-based very-high-energy gamma-ray observatory that will allow for observations in the >10 GeV range with unprecedented photon statistics and sensitivity. This will enable the investigation of the yet-marginally explored physics of short-time-scale transient events. CTA will thus become an invaluable instrument for the study of the phys
This article introduces the Framework for Integrating Rights and Equality (FIRE): a transdisciplinary framework that builds synergies between human rights-based (HRBA) and gender equality approaches to disaster risk reduction (DRR) and climate change adaptation (CCA). It describes how FIRE has been developed, tested and refined over the course of a five-year regional learning and technical coopera
We report on precise Doppler measurements of L231-32 (TOI-270), a nearby M dwarf (d = 22 pc, M = 0.39 M, R = 0.38 R), which hosts three transiting planets that were recently discovered using data from the Transiting Exoplanet Survey Satellite (TESS). The three planets are 1.2, 2.4, and 2.1 times the size of Earth and have orbital periods of 3.4, 5.7, and 11.4 d. We obtained 29 high-resolution opti
Ecosystem services (ES) are an increasingly popular policy framework for connecting biodiversity with human well-being. These efforts typically assume that biodiversity and ES covary, but the relationship between them remains remarkably unclear. Here we analyse >500 recent papers and show that reported relationships differ among ES, methods of measuring biodiversity and ES, and three different app
Psychosocial treatments improve outcome in Pediatric bipolar disorder (PBD), but few are developed specifically for adolescents and none has been evaluated in Europe. This study evaluates family-focused cognitive-behavioral therapy for adolescents (ages 13-18) with PBD in routine psychiatric care in Sweden, adapted for teenagers in a European setting from the Child and Family-Focused Cognitive Beh
Complex scientific questions often require collaboration between scientists to access scientific instruments (deS. Price, Res Policy 13:3–20, 1984; Shrum et al. 2007, Structures of scientific collaboration, The MIT Press, 2007), knowledge and social capital from scientists outside of their immediate networks (Burt, Am J Sociol 110:349–399, 2004; Collins, Tacit and explicit knowledge, University of
The mucolytic human gut microbiota specialist Akkermansia muciniphila is proposed to boost mucin-secretion by the host, thereby being a key player in mucus turnover. Mucin glycan utilization requires the removal of protective caps, notably fucose and sialic acid, but the enzymatic details of this process remain largely unknown. Here, we describe the specificities of ten A. muciniphila glycoside hy
Urban green spaces are important for climate change adaptation, in particular to reduce the negative impacts of heat waves on human well-being. However, in growing cities urban green spaces are under pressure due to increasing housing demand and densification. Municipalities face the challenge of addressing both the housing shortage and the need for climate change adaptation on limited space. This
The snowmelt runoff process from small basins is discussed. A differentiation is made between overland flow in the snowpack and groundwater flow induced by infiltrating meltwater. The effect of variations of the snowmelt intensity on streamflow is studied. It is shown that the runoff is high from the first day of snowmelt runoff if the streamflow is caused by overland flow, and that there are pron
It is argued that the capacity to focus attention is crucial for intentional communication. Intentional communication is goal-intended; directed at changing mental states and as a consequence behaviour; about a referential object common to sender and recipient; and about objects that may be context-and referent-independent. Three different kinds of attention is discerned: scanning, attention attra
