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OBJECTIVES: Patient-reported outcome measures (PROMs) are important for clinical practice and research. Given the high unmet need, our aim was to develop a comprehensive PROM for systemic sclerosis (SSc), jointly with patient experts. METHODS: This European Alliance of Associations for Rheumatology (EULAR)-endorsed project involved 11 European SSc centres. Relevant health dimensions were chosen an
Background: Vasopressin concentration is typically higher at night, during stress, and in males, but readily lowered by water intake. Vasopressin is also a causal candidate for cardiometabolic disease, which shows seasonal variation. Objective: To study whether vasopressin concentration varies by season in a temperate climate. Methods: The vasopressin surrogate marker copeptin was analyzed in fast
A large number of variants identified through clinical genetic testing in disease susceptibility genes are of uncertain significance (VUS). Following the recommendations of the American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP), the frequency in case-control datasets (PS4 criterion) can inform their interpretation. We present a novel case-control
The solution of multi-field problems and the numerical implementation by means of the finite element method constitute a sophisticated part of the characterisation of industrial processes. A comprehensive implementation framework for such a system of coupled field equations into a non-linear large strain finite element formulation is provided. The procedure is derived for a micromorphic approach i
Articular cartilage and meniscus transfer and distribute mechanical loads in the knee joint. Degeneration of these connective tissues occurs during the progression of knee osteoarthritis, which affects their composition, microstructure, and mechanical properties. A deeper understanding of disease progression can be obtained by studying them simultaneously. Time-resolved synchrotron-based X-ray pha
The rate of recombination impacts on rates of protein evolution for at least two reasons: it affects the efficacy of selection due to linkage and influences sequence evolution through the process of GC-biased gene conversion (gBGC). We studied how recombination, via gBGC, affects inferences of selection in gene sequences using comparative genomic and population genomic data from the collared flyca
In this study, the effects of fin configurations and layouts on thermal and hydraulic performances of printed circuit heat exchangers (PCHEs) with supercritical liquefied natural gas as the working fluid are studied by a numerical method, and the overall heat transfer performance of various parameters is evaluated by the JF factor. Firstly, the effect of four different airfoil configurations, i.e.
KUTE04 Manus och dramaturgi med barn och unga Lunds universitet Konstnärliga fakulteten KUTE04, Manus och dramaturgi med barn och unga, 7,5 högskolepoäng Script and Dramaturgy with Children and Youth, 7.5 credits Grundnivå / First Cycle Fastställande Kursplanen är fastställd av Institutionsstyrelsen vid Teaterhögskolan i Malmö 2023-06- 14 att gälla från och med 2024-01-15, vårterminen 2024. Allmän
BACKGROUND AND OBJECTIVE: Bacillus Calmette-Guérin (BCG) reduces disease recurrence and progression in intermediate- and high-risk non-muscle-invasive bladder cancer (NMIBC). BCG-associated adverse events during instillations are common, leading to treatment cessation. Prophylactic use of quinolones in conjunction with BCG instillations is one approach for reducing BCG-associated adverse events. O
ImportanceThe management of complications following oral cavity squamous cell carcinoma (OCSCC) surgery can be challenging. Previous studies show conflicting results on complication risks after preoperative radiotherapy (RT), necessitating a randomized controlled trial (RCT).ObjectiveTo compare early complications during hospitalization for OCSCC surgery between patients receiving preoperative acc
Endovascular therapy (EVT) has proven benefit for patients with anterior circulation large vessel occlusion (LVO) strokes with moderate-to-severe deficits, but its value in patients presenting 6-24 hours after onset with mild symptoms (NIH Stroke Scale score ≤5) remains unclear. This journal club article examines a retrospective analysis of CLEAR registry data comparing EVT with medical management
Due to a warming climate, tundra ecosystems are subject to shrub and treeline expansions which could lead to increased above- but decreased belowground carbon (C) stocks. An observed low soil C stock in some subarctic forests and tall shrublands has been suggested to be induced by priming of organic matter decomposition, possibly mediated by ectomycorrhizal fungi. On the other hand, the higher bel
Amerikanska polisens dödliga våld mot svarta människor är ett människorättsproblem som inte är nytt. Ett människorättsproblem som visar tydligt hur den strukturella rasismen samverkar i amerikanska institutioner. Den amerikanska polisen blir hållna om ryggen och detta har skapat en systematisk straffrihet. Syftet med denna studie är att visa på hur den rättsliga hanteringen och dess rättsliga påfö
Semantic Web technology has attracted much interest for its ability to integrate and deliver information from different sources, and increasingly, geodata are being published as triple data according to the graph structure laid out in the Resource Description Framework (RDF). Although the Semantic Web already contains a large volume of geotagged information, there is still a lack of suitable geome
With the rise of serious environmental threats brought about by climate change, governments, organizations, leaders, and academics are constantly seeking ways to address this growing concern, and the development of a circular economy model is seen as a viable solution towards ensuring environmental sustainability alongside economic growth. The concept of circular economy has been defined in a mult
Seeing how climate change disproportionately affects women and children, the voices of young people and women are vital to incorporate into discussions and decision-making processes regarding climate change. This thesis explores the experiences of young women in the climate movement who have participated at the COP climate conferences between 2015-2023. By drawing on the theoretical framework of f
Denna uppsats behandlar den romerska lagen lex Aquila och dess roll i det svenska rättsväsendet i stort och dess påverkan på skadeståndsrätten särskilt. Den syftar till att definiera lex Aquilias regler och bakgrund. Syftet är även att visa när lex Aquilias regler tillträde Sverige och hur dom har tillämpats. Utifrån ovannämnda redogörs följande frågeställningar: Lex Aquilias uppkomst och innehållThe purpose of the essay is to examine the ancient roman law lex Aquilia and its role in the Swedish regulatory framework. The essay is focused on lex Aquilias influence on Swedish tort law. The purpose is to define lex Aquilias code and its historic background. It also treats in which time frame it started to impact Swedish law and how it has been applied. Based on the above the following questio
The European Union’s identity as a normative power has long been examined and contested, most famously by Ian Manners' conceptualization in his 2002 work, Normative Power Europe. This study critically reassesses the EU's proposed identity through the lens of its responses to two pivotal crises: the Syrian conflict (2012-2015) and the 2016 EU-Türkiye Refugee Deal. The research interrogates
