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Purpose: The platelet-derived growth factor (PDGF) signalling pathway is often dysregulated in cancer and PDGF-receptor expression has been linked to unfavourable prognostic factors in breast cancer (e.g. ER negativity, high Ki67 and high grade). This study aimed to evaluate the expression of PDGFRα, PDGFRβ and ligand PDGF-CC in breast cancer in relation to molecular subtypes and prognosis. Method

Objectives Critically ill COVID-19 patients admitted to the intensive care unit (ICU) are at an increased risk of acquiring bacterial bloodstream infections (BSI). We aimed to describe patient characteristics, risk factors, and the microbiological spectrum in blood cultures and evaluate the impact of ICU-acquired BSI on outcomes in a Nordic setting. Methods A prospective multicenter cohort study w

Disclosed is a method (310) for providing operational feedback during power transfer in a wireless power transfer system. The wireless power transfer system comprises a power transmit device arranged to transfer power over an inductive wireless power transfer interface operating at a transmit frequency to a power receive device. The wireless power transfer system is adapted to transfer information

In order for any learning-based model to be considered reliable, it needs a well-behaved uncertainty or confidence estimate. Most modern neural networks do produce a confidence estimate in the form of their softmax output probability. However, the softmax probability is invalid for out-of-distribution data. Gaussian processes are known to produce a well-behaved confidence estimate that is aware of

In this paper, we propose the design of a roof-glass integrated microstrip antenna for vehicular SDARS tuners. The proposed microstrip antenna is sandwiched inside a multi-layer roof glass and uses a solar-heat reduction coating on the bottom side of the glass as ground plane. To offset the effect of the lossy glass, parasitic elements are added to enhance the antenna gain. Simulation results show

Although variations in temperature have a profound impact on cardiac function, little is known regarding the excitation and contractile parameters over a broad temperature interval. In view of the clinical implications of lowered temperature in resuscitation and in cardiac preservation/evaluation for transplantation, we have examined the contractile function using Langendorff perfused hearts and i

The unquenchable thirst for bandwidth to support next-generation wireless systems is increasingly bringing D-band into the spotlight. This work proposes a scalable D-band patch antenna that features both coplanar and stacked parasitic patch structures. By leveraging inter-patch coupling, different coplanar parasitic elements are excited across different frequency bands, enabling multi-mode operati

Although 6G is not only about higher data rates, its envisioned peak data rate of 1 terabits per second requires larger frequency bandwidth than what 5G millimeter wave bands offer. Therefore, new frequency bands have been allocated in the sub-THz range for 6G applications. This paper reviews the concept of distributed deployment to provide coverage in sub-THz bands, focusing on the design and imp

In multi-user multiple-input multiple-output (MU-MIMO) systems, the non-linear behavior of the power amplifiers (PAs) may cause degradation of the linear precoding schemes dealing with interference between user equipments (UEs), e.g., the zero-forcing (ZF) precoder. One way to minimize this effect is to use digital-pre-distortion (DPD) modules to linearize the PAs. However, using perfect DPD modul

Together with response time the force of responses to stimuli can provide important clues about cognitive and affective processes. However, while there has been much discussion of factors involved in the accurate measurement of response time (RT), key issues and assumptions in assessment of response force (RF) have been far less studied. Here, hierarchical Bayesian analysis is used to examine the

Abstract in UndeterminedThe increasing effectiveness and efficiency of modern society is not only beneficial, but also liable for new or increased vulnerabilities. The seemingly ever-increasing complexity of modern society is in other words bringing new challenges for safety, security and sustainability. At the heart of these challenges lay an incremental increase in dependencies between sectors,

Abstract in UndeterminedOur world is changing and cities and regions are increasingly understood not only asplaces, but also as vital hubs in national and global networks, through which people,capital, goods and services flow to ensure the functioning of society, as we know it. Peopleand capital are increasingly concentrated in these hubs, which aside of positive effects onefficiency also is assoc

Adverse early-life conditions have lasting effects on old-age health and mortality (Almond, 2006, Barker, 1992, Barker, 1994, Mazumder et al., 2010 and Roseboom et al., 2006). Some have even considered reductions in early life disease exposure to be a primary driver of historical mortality declines (Finch and Crimmins, 2004). Consequently, understanding the mechanisms through which early and later

This pilot study aimed to investigate whether mammographic compression procedures might cause shedding of tumor cells into the circulatory system as reflected by circulating tumor cell (CTC) count in peripheral venous blood samples. From March to October 2012, 24 subjects with strong suspicion of breast malignancy were included in the study. Peripheral blood samples were acquired before and after

Purpose: The increase in clinical trials with androgen receptor (AR)-targeting drugs emphasizes the need of clarifying the role of AR expression in different breast cancer subtypes. AR confers good prognosis in estrogen receptor positive (ER+) breast cancer, but its role in ER-negative (ER−) breast cancer is unclear. The aim of this study was to elaborate on previous findings of a differential pro

Although recommended by the Kidney Disease Improving Global Outcomes, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPICR) creatinine equation was not targeted to estimate glomerular filtration rate (eGFR) among older adults. The Berlin Initiative Study (BIS1CR) equation was specifically developed in older adults, and the Lund-Malmö revised (LMRCR) and the Full Age Spectrum (FASCR) eq

Recent years have seen the development of new iron-centered N-heterocyclic carbene (NHC) complexes for solar energy applications. Compared to typical ligand systems, the NHC ligands provide Fe complexes with longer-lived metal-to-ligand charge transfer (MLCT) states. This increased lifetime is ascribed to strong ligand field splitting provided by the NHC ligands that raises the energy levels of th