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In this review, we summarise the current understanding of the potential link between cancer and anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), including granulomatosis with polyangiitis (Wegener's; GPA) and microscopic polyangiitis (MPA). As is true for many autoimmune or inflammatory rheumatic diseases, AAV diagnosis and therapy are associated with an increased risk of de novo
To develop concise, up-to-date, patient-focused, evidence-based, expert consensus guidelines for the management of knee osteoarthritis (OA), intended to inform patients, physicians, and allied healthcare professionals worldwide.
Radioactive beams of B-14,B-15 produced by fragmentation of a primary Ar-40 beam were directed onto a Pb target to investigate the neutron breakup within the Coulomb field. The experiment was performed at the LAND/(RB)-B-3 setup. Preliminary results for the Coulomb dissociation cross sections as well as for the astrophysically interesting inverse reactions, B-13,B-14(n,gamma), are presented.
First, we study geometric variants of the standard set cover motivated by assignment of directional antenna and shipping with deadlines, providing the first known polynomial-time exact solutions. Next, we consider the following general (non-necessarily geometric) capacitated set cover problem. There is given a set of elements with real weights and a family of sets of the elements. One can use a s
Objective To develop evidence-based recommendations for the diagnosis of knee osteoarthritis (OA). Methods The multidisciplinary guideline development group, representing 12 European countries, generated 10 key propositions regarding diagnosis using a Delphi consensus approach. For each recommendation, research evidence was searched systematically. Whenever possible, the sensitivity, specificity a
The Tile hadronic calorimeter of the ATLAS detector has undergone extensive testing in the experimental hall since its installation in late 2005. The readout, control and calibration systems have been fully operational since 2007 and the detector has successfully collected data from the LHC single beams in 2008 and first collisions in 2009. This paper gives an overview of the Tile Calorimeter perf
The MAX IV pro-injector will have one thermionic and one photocathode S-band RF gun, where the former will be used for ring injections. During ring injections, the bunches leaving the pre-injector have a structure that consists of ten 10 ns bunch trains, each containing three bunches. A chopper system consisting of two striplines and an adjustable aperture is used, where the desired bunch structur
Objectives: To develop European League Against Rheumatism (EULAR) recommendations for the management of large vessel vasculitis. Methods: An expert group (10 rheumatologists, 3 nephrologists, 2 immunolgists, 2 internists representing 8 European countries and the USA, a clinical epidemiologist and a representative from a drug regulatory agency) identified 10 topics for a systematic literature searc
Climate change poses a serious challenge to sustainable urban development, placing many cities at risk. Climatic conditions are changing to such an extent that the capacity of urban institutions and associated governance systems to deal with climatic extremes and variability is being reduced. New approaches for urban climate change adaptation are thus urgently needed. There is an increasing conse
Helsingborg, a coastal city in southern Sweden, initiated a long-term redevelopment project called H+ in 2009, aiming to convert industrial harbor space in the city's south into a new, livable urban neighborhood and city center. The project aims to create an open and ‘tolerant city’ in Helsingborg over the next twenty years. In 2010-2011, H+ used an open-source planning method as a strategy to inc
This report identifies fundamental problems to be addressed in order to build relevant clinical tests of human balance while standing. The stated purpose of these tests is identification of lesion site and/or definition of functional balance deficits in a specific patient. During a recent consensus meeting (ESCEBD), 60 researchers and experienced clinical users of posturography (14 European countr
Objective To derive simple and clinically useful ultrasound-based rules for discriminating between benign and malignant adnexal masses. Methods In a multicenter study involving nine centers consecutive patients with persistent adnexal tumors underwent transvaginal gray-scale and Doppler ultrasound examination using a standardized examination technique and standardized terms and definitions. Inform
Finns det något utpräglande för debutverk eller är debutverk snarare en utgångspunkt för fortsatt skrivande? Föreliggande magisteruppsats beskriver Edith Södergrans, Karin Boyes, Elsa Graves, Sonja Åkessons och Katarina Frostensons debutverk. Dessa poeter analyseras i förhållande till senare verk. Metoden är textcentrerad och komparativ. Syftet med uppsatsen är att genom en jämförelse mellan debut
Aim. This paper reports the findings of a study that aimed to elucidate the meaning of fatigue for women with multiple sclerosis (MS). Background. Living with chronic illness can involve giving up usual activities. MS is a chronic autoimmune disease of the central nervous system. Fatigue is a common experience among people with MS; however, little is known about the meaning of fatigue experienced
Samples were prepared for ultrastructural studies of the intact interface between metallic implants and tissue by transmission electron microscopy. The method is based on plastic embedding of implant and tissue and subsequent removal of the bulk metal by electrochemical dissolution (electropolishing), to facilitate preparation of ultrathin sections for transmission electron microscopy. Surface sen
C4b-binding protein (C4BP) is a regulator of the classical complement pathway C3 convertase (C4bC2a complex). It is a disulfide-linked polymer of seven alpha-chains and a unique beta-chain; the alpha- and beta-chains are composed of eight and three complement control protein (CCP) domains, respectively. To elucidate the importance of the polymeric nature of C4BP and the structural requirements for
