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Here we investigated the impact of WNT5A signaling on aerobic glycolysis and evaluated its effects on breast cancer cell migration/invasion. WNT5A signaling reduced migration and lactate production and caused selective down-regulation of the glycolytic enzyme phosphofructokinase platelet-type (PFKP). These events occurred in parallel with a WNT5A-induced inhibition of β-catenin signaling. Support
Background and Purpose: In this multicentre phase I-II trial we evaluated the feasibility and efficacy of capecitabine and oxaliplatin followed by the combination of these two drugs with radiotherapy in patients with locally advanced pancreatic or biliary tract cancer. Material and methods: Thirty-nine patients with inextirpable adenocarcinoma of the pancreas, gallbladder or extrahepatic bile duct
High latitude mires are key ecosystems in the context of climate change since they store large amounts of carbon while constituting an important natural source of methane (CH4). However, while a growing number of studies have investigated methane fluxes (FCH4) at the plot- (~1 m2) and ecosystem-scale (~0.1–0.5 km2) across the boreal biome, variations of FCH4 magnitudes and drivers at the mesoscale
This article summarises the current understanding of the heterogeneity of type 1 diabetes from a June 2024 international Expert Forum organised by the editors of Diabetes, Diabetes Care, and Diabetologia. The Forum reviewed key factors contributing to the development and progression of type 1 diabetes and outlined specific, high-priority research questions. Knowledge gaps were identified and, nota
The future role of boreal forests in the global carbon cycle is uncertain given the rapid climate change in high latitudes. At the landscape scale, heterogeneity in stand age and land cover, contributions from terrestrial and aquatic fluxes, and harvest export may create complex carbon cycle-climate interactions. However, the integrated response of the net landscape carbon balance (NLCB) to inter-
Deposition of phosphorus (P) is important for the nutrient supply to forests and open land but also contributes to the eutrophication of surface waters. Deposition to open land can be measured as bulk deposition while deposition to forests cannot be measured directly, due to internal circulation of P within forest canopies. This study aimed to quantify the total deposition of P to open land and fo
The interaction between chitosans and Langmuir monolayers mimicking cell membranes has been explained with an empirical scheme based on electrostatic and hydrophobic forces, but so far this has been tested only for dimyristoyl phosphatidic acid (DMPA). In this paper, we show that the mode of action in such a scheme is also valid for dipalmitoyl phosphatidyl choline (DPPC) and dipalmitoyl phosphati
Popular Abstract in Swedish Det sägs att ögonen är själens spegel och att man genom att titta på någons ögon kan säga något om personens sinnesstämning och hur personen mår. Forskning kring ögonrörelser har visat att man genom att mäta ögats rörelser kan tolka hur den visuella informationen som vi tar in genom ögonen har behandlats. Eftersom det är hjärnan som styr muskulaturen runt ögat som i sinThis doctoral thesis has signal processing of eye-tracking data as its main theme. An eye-tracker is a tool used for estimation of the point where one is looking. Automatic algorithms for classification of different types of eye movements, so called events, form the basis for relating the eye-tracking data to cognitive processes during, e.g., reading a text or watching a movie. The problems with t
MÅL. För att svara på hur psykodynamisk psykoterapi av posttraumatiskt stressyndrom upplevdes bland flyktingar analyserades och jämfördes deras erfarenheter av grupp- och individuell psykoterapi. METOD. 10 tidigare patienter från en öppenvårdsmottagning specialiserad på behandling av patienter med erfarenheter av migration, krig och tortyr rekryterades till studien. 5 patienter hade gått i psykoanOBJECTIVE. How is psychodynamic psychotherapy experienced by refugees with posttraumatic stress disorder? To answer this, patients’ experiences of group and individual psychotherapy were analyzed and compared. METHOD. Semi-structured interviews were carried out with 10 former patients at a Swedish outpatient clinic specialized in the treatment of patients with experiences of migration, war, and to
Brazed stainless steel joints are critical in heat exchanger applications but often suffer from residual stresses and brittle intermetallics. Using in-situ synchrotron X-ray diffraction and fluorescence at the DanMAX beamline, we investigated Fe-based filler joints in SS316 under tensile loading. Elemental mapping and phase analysis revealed distinct interfacial solidification zones (ISZ), atherma
Background: Co-occurring substance use disorders, and mental disorders are associated with significant suffering, high risks of violent reoffending and relapse in both substance use and psychotic episodes. Treatment for co-occurring substance use disorders in forensic mental health settings would benefit from incorporating patients’ understanding of their disorders. Method: Using an interpretative
ESS, a European Research Infrastructure Consortium (ERIC), is getting ready to be a leading multidisciplinary facility with the world's most potent neutron source. Dedicated to scientific breakthroughs, ESS focuses on materials, energy, health, and environmental research to address key societal challenges. ESS will host 22 specialized scientific instruments selected to cover a broad range of exper
Effective environmental policies for the tropics depend on accurate, representative scientific data. However, there is strong evidence from particular disciplines and regions that existing research is patchily distributed. Here, we show that poor representation of sampling and citation in some biomes and across key environmental gradients from all disciplines for the entire tropics may lead to fla
Boreal forests play a crucial role in the global carbon cycle and currently act as an important carbon sink. At the same time, these forests are increasingly affected by intensive forest management and a changing disturbance regime driven by climate change. Clear-cutting has been the dominant harvesting method in managed boreal forests, while wildfire, although rare over the last century in Sweden
This study presents an integrated simulation framework that combines agent-based transport modeling with probabilistic load-flow analysis to quantify power system loading of long-haul heavy-duty electrification. The approach is applied to a case study considering fully electrified road freight in the Skåne region in Sweden, using high-resolution transport demand data and the actual power grid mode
BACKGROUND:: In soft tissue sarcoma, better distinction of high-risk and low-risk patients is needed to individualize treatment and improve survival. Prognostic systems used in clinical practice identify high-risk patients based on various factors, including age, tumor size and depth, histological type, necrosis, and grade. METHODS:: Whole-tumor sections from 239 soft tissue sarcomas of the extrem
Pheromone-based monitoring could be a very efficient method to assess the conservation status of rare and elusive insect species, but there are still few studies for which pheromone traps have been used to obtain information on presence, abundance, phenology and movements of such insects. We performed a mark-recapture study of two threatened saproxylic beetles, Osmoderma eremita (Scarabaeidae) and
