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Recycling of livestock manure in agroecosystems has been shown to enhance the sustainability of food production and reduce adverse environmental consequences from intensive crop-livestock systems. However, the effect of manure application on the associations between soil quality and ecosystem multifunctionality still remains poorly understood. Hereby, we used a five-year field experiment to invest
PMCA4 is a critical regulator of Ca2+ homeostasis in mammalian cells. While its biological and prognostic relevance in several cancer types has already been demonstrated, only preclinical investigations suggested a metastasis suppressor function in melanoma. Therefore, we studied the expression pattern of PMCA4 in human skin, nevus, as well as in primary and metastatic melanoma using immunohistoch
Abstract in ItalianQuesta esposizione propone in maniera teoretica una critica dell’esagerazione come approccio utile a qualsiasi filosofia che si occupi dei cosiddetti temi esistenziali. Si segue l’esempio dell’esagerazione per proporre un pensare oltre l’essere, in contrasto con la questione dell’essere senza esagerazione. Infine, si propone la critica propria dell’esagerazione come atteggiamentThis theoretical exposition proposes the critique of exaggeration as the approach to any philosophy that deals with the so-called existential themes. It provides the example of exaggeration in thinking beyond being in contrast to the question of being without exaggeration. Finally, it proposes the critique of exaggeration as a philosophical attitude that resists the temptation to seriously engage
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 ×
The mechanisms leading to the occurrence of extreme weather and climate events are varied and complex. They generally encompass a combination of dynamic and thermodynamic processes, as well as drivers external to the climate system, such as anthropogenic greenhouse gas emissions and land use change. Here we present the ExtremeX multi-model intercomparison experiment, which was designed to investig
The vector-boson production cross section for the Higgs boson decay in the Formula Presented channel is measured as a function of kinematic observables sensitive to the Higgs boson production and decay properties as well as integrated in a fiducial phase space. The analysis is performed using the proton-proton collision data collected by the ATLAS detector in Run 2 of the LHC at Formula Presented
We have previously described a new series of selective and orally available galectin-1 inhibitors resulting in the thiazole-containing glycomimetic GB1490. Here, we show that the introduction of polar substituents to the thiazole ring results in galectin-1-specific compounds with low nM affinities. X-ray structural analysis of a new ligand-galectin-1 complex shows changes in the binding mode and l
Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia after Alzheimer disease (AD). Efforts in the field mainly focus on familial forms of disease (fFTDs), while studies of the genetic etiology of sporadic FTD (sFTD) have been less common. In the current work, we analyzed 4,685 sFTD cases and 15,308 controls looking for common genetic determinants for sFTD. We found
Cardioneuroablation has emerged as a potential alternative to cardiac pacing in selected cases with vasovagal reflex syncope, extrinsic vagally induced sinus bradycardia-arrest or atrioventricular block. The technique was first introduced decades ago, and its use has risen over the past decade. However, as with any intervention, proper patient selection and technique are a prerequisite for a safe
Within a collaboration between MAX-lab and BESSY a one stage seeded HGHG-FEL has been set up at Maxlab. BESSY has built the undulator system consisting of a modulator, a radiator and an electromagnetic chicane. BESSY has also installed three types of diagnostic tools: optical fibres for a fast Cherenkov beam loss detection, optical fibres for absolute dose measurements via their radiation-induced
The History of African Development – published by the African Economic History Network (AEHN) – aims to draw experts in the field of African History, Economics and African Development Studies together around an open access textbook. The textbook is primarily intended for teachers/lecturers and undergraduate students, at African universities, but also for an interested wider public audience. The AE
This study investigates people’s associations between the exchange of sexual services for payment and different sexual activities. Sex work entails a range of activities, from in person services to online performances. To date, no study has asked about the activities individuals associate with the exchange of sexual services for payment. The relationship between the exchange of sexual services for
PURPOSEAdjuvant radiotherapy (RT) is used for women with early-stage invasive breast cancer treated with breast-conserving surgery. However, some women with low risk of recurrence may safely be spared RT. This study aimed to identify these women using a molecular-based approach.METHODSWe analyzed two randomized trials of women with node-negative invasive breast cancer to ± RT following breast-cons
Background: The emergence of disease-modifying Alzheimer’s (AD) treatments provides new hope to patients and families but concerns have been raised about the preparedness of healthcare systems to provide timely access to such treatments because of a combination of a complex diagnostic process and a large prevalent pool. Objectives: We assess the preparedness of Sweden, a high-income country known
The objectives were to translate the University of Jyvaskyla Active Aging Scale (UJACAS) to Swedish, to establish semantic equivalence and evaluate psychometric properties for use among persons 55 years and older in Sweden. The UJACAS contains 17 items to be self-assessed regarding goals, abilities, opportunity, and activity. Psychometric properties content validity, data quality including floor a
The cultivated peanut (Arachis hypogaea L.) is an important oilseed crop worldwide, and fatty acid composition is a major determinant of peanut oil quality. In the present study, we conducted a genome-wide association study (GWAS) for nine fatty acid traits using the whole genome sequences of 160 representative Chinese peanut landraces and identified 6-1195 significant SNPs for different fatty aci
The Swedish HE Ordinance requires all supervisors of doctoral students to undergo introductory training. The content, goals, learning outcomes and duration is not specified by the Ordinance and thus practices vary between institutions. In 2009/2010, a new study program for doctoral supervisors was launched at Lund University. The program was designed to:- provide research-based support for doctora
