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Long-term results from a phase II study of single agent paclitaxel (Taxol) in previously platinum treated patients with advanced ovarian cancer : the Nordic experience

BACKGROUND: Owing to the wide spread perception of a possible benefit from paclitaxel in the second-line situation the Nordic Gynecologic Oncology Group (NGOG) conducted two prospective phase II studies of paclitaxel single agent treatment (175 mg/m2, three-hour i.v. infusion with standard pre-medication every third week) in patients with relapsing or progressing epithelial ovarian cancer followin

Interdisciplinary risks–a delicate balance between trust and critical review

We argue that the subject matter and objectives of risk science establish it as an inherently interdisciplinary field, closely connected to both academic disciplines and practical applications. However, risk research faces a range of interdisciplinary challenges. These include the production of low-quality research—characterised by superficial and insufficiently grounded conclusions—a lack of mutu

InfraVis-The Swedish Research Infrastructure for Visualization Support

Essentially all academic research of today relies on analysis of data from a wide range of sources. Several underpinning, and rapidly developing, technologies are supporting the analysis of this data. Visualization serves as an interface to this ecosystem of tools and methods and integrates them into environments supporting scientific workflows, effectively sharing cognitive load between computers

Impact of spring rape varieties on protein extraction from press cake, emulsifying properties and antinutrient content

BACKGROUND: Rapeseed is the second most cultivated oilseed globally after soybean and a protein-rich press cake is generated after liberation of the oil. However, its use in food applications is limited by high levels of anti-nutrients such as glucosinolates and phytic acid. Although differences between botanical varieties are known, controlled comparisons of modern spring varieties for protein fu

Soil Microbial Communities Adjust Thermal Traits and Carbon Allocation in Response to Climate Manipulations in Subtropical Forest and Cropland

Soil microorganisms regulate carbon (C) cycling, and their growth and respiration are strongly dependent on temperature. Yet it remains unclear how warming alters microbial thermal traits, community structure, and the balance between microbial respiration and growth, particularly in subtropical ecosystems where high temperatures coincide with low soil moisture, potentially constraining microbial a

Exploring novel joining technique of Gas Actuated Bonding by utilizing In-situ Environmental-TEM

The reliability of a critical industrial component is decided by the durability of the weakest joint or spot. For applications involving high-temperature operational conditions especially coupled with corrosive environments like fuel cell interconnections, molten metal baths, etc., the joints are the most vulnerable regions for catastrophic failure due to localized material degradation by selectiv

Neural network connectivity by optical broadcasting between III-V nanowires

Biological neural network functionality depends on the vast number of connections between nodes, which can be challenging to implement artificially. One radical solution is to replace physical wiring with broadcasting of signals between the artificial neurons. We explore an implementation of this concept by light emitting/receiving III-V semiconductor nanowire neurons in a quasi-2D waveguide. They

Fransk litteratur i Sverige 1830-1900. Översättning, reception och spridning

The article presents some results from an international project on the introduction of French literature in Scandinavia during the 19th century. A point of departure is the database BREFS (Bibliographie du Réalisme Français en Scandinavie), containing the translations of novels, short stories, poetic works and theatre plays that were published in Denmark, Finland, Iceland, Norway and Sweden in boo

Enhanced science-stakeholder communication to improve ecosystem model performances for climate change impact assessments.

In recent years, climate impact assessments of relevance to the agricultural and forestry sectors have received considerable attention. Current ecosystem models commonly capture the effect of a warmer climate on biomass production, but they rarely sufficiently capture potential losses caused by pests, pathogens and extreme weather events. In addition, alternative management regimes may not be inte

Direct and endothelium-linked serotonergic control of vascular tone in human uterine and umbilical arteries

Popular Abstract in Swedish Blodflödet i livmoder- och navelsträngsartärerna påverkar bl a faktorer såsom tillväxt av livmoderns slemhinna, vidhäftningen av ägget och fostertillväxt. Det har betydelse för dessa funktioner både vid normal graviditet och vid tillstånd såsom t ex, havandeskapsförgiftning och tillväxthämning hos fostret. Blodflödet regleras av faktorer som inverkar på den glatta muskuThe serotonergic vascular control was investigated by in vitro pharmacology in the human uterine and umbilical arteries. The localisation of immunoreactive (IR) neuropeptide Y (NPY) and the influence of NPY on the adrenergic vascular effects in the human uterine artery were also studied. NPY-IR nerve fibres were observed predominantly at the media-adventitial border of the uterine artery. About 50

Production, Purification and Characterization of Antimicrobial Biomolecules from Potential Probiotic Lactic Acid Bacteria

Development and optimization of the production of lactic acid bacteria (LAB) and their attendant 'natural' inhibitors as biopreservatives to control undesirable bacteria currently remains a primary focus of several laboratories involved in research concerning food safety and quality. Strategies utilized to study incorporation of biopreservatives into food include either direct use of LAB-strains o

New rules for the spaces of urbanity.

The best way to conceive semiotical spaces that are not identical to single buildings, such as a cityscape, is to define the place in terms of the activities occurring there. This conception originated in the proxemics of E. T. Hall and was later generalized in the spatial semiotics of Manar Hammad. It can be given a more secure grounding in terms of time geography, which is involved with trajecto

Placing articles in the large publisher nations: Is there a "free lunch" in terms of higher impact?

This paper deals with the role of a journal's publisher country in determining the expected citation rates of the articles published in it. We analyze whether a paper has a higher citation rate when it is published in one of the large publisher nations, the U.S., U.K., or the Netherlands, compared to a hypothetical situation when the same paper is published in journals of different origin. This wo