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Groups associated to surfaces isogenous to a higher product of curves can be characterized by a purely group-theoretic condition, which is the existence of the so-called ramification structure. In this paper, we prove that infinitely many quotients of the Grigorchuk groups admit ramification structures. This gives the first explicit infinite family of 3-generated finite 2-groups with ramification
In this chapter, the authors highlight that the challenges related to managing modern projects are that the management problems have changed since traditional project management methods were developed. This calls for new project management methods, adapted to situations of rapid technological change and flexibility. The authors identify and highlight the limitations of both traditional and agile m
This chapter rests on participant observation and interviews from Malungs folkhögskola, the distance education “Folkmusik fiol”, led by the doyen of Swedish folk music pedagogy, Jonny Soling. With his life-long experience of fiddle education for grown-ups, Soling has unique knowledge of holistic fiddle didactics. At the age of 73, he still attracts course participants from all ages and all parts o
The p53 tumor suppressor protein can induce both apoptosis and cell cycle arrest. Moreover, we and others have shown previously that p53 is a potent mediator of differentiation. For example, expression of ptsp53, a temperature-inducible form of p53, induces differentiation of leukemic monoblastic U-937 cells. The functions of p53 have for long been believed to be dependent on the transactivating c
Fix some p∈ [0 , 1] and a positive integer n. The discrete Bak–Sneppen model is a Markov chain on the space of zero-one sequences of length n with periodic boundary conditions. At each moment of time a minimum element (typically, zero) is chosen with equal probability, and it is then replaced alongside both its neighbours by independent Bernoulli(p) random variables. Let ν(n)(p) be the probability
Proteomics is widely utilized to understand the function of cellular processes at the molecular level. Using liquid chromatography interfaced with mass spectrometry (LC-MS)-based proteomics, thousands of proteins can be identified and quantified in a single experiment and their relationship and interactions can be analyzed. This makes the analysis of high-throughput proteomics data a cornerstone i
Background: Norm values for patient reported outcomes, that is knowledge about how the general population of women rate their breast-related satisfaction and quality of life, are necessary to interpret the meaning of scores. The aims of this study were to create Swedish normative values for the BREAST-Q reduction/mastopexy module and to describe what healthy women are most satisfied/dissatisfied w
The risk assessment of pesticide residues in food is a key priority in the area of food safety. Most jurisdictions have implemented pre-marketing authorization processes, which are supported by prospective risk assessments. These prospective assessments estimate the expected residue levels in food combining results from residue trials, resembling the pesticide use patterns, with food con-sumption
3D food printing is a fascinating novel technology with many promising applications, from futuristic-looking food topersonalized nutrition, and space food for astronauts. However, much of its potential is only realized in the laboratoryor speculated in the literature. This research is an attempt to explore the barriers to the diffusion of this newtechnology to the wider market. It argues that the
With the continuous increase of rapid urbanization and population growth, sustainable urban land-use planning is becoming a more complex and challenging task for urban planners and decision-makers. Multi-objective land-use allocation can be regarded as a complex spatial optimization problem that aims to achieve the possible trade-offs among multiple and conflicting objectives. This paper proposes
We present the design, prototype developments and test results of the new time-of-flight detector (ToFD) which is part of the R3B experimental setup at GSI and FAIR, Darmstadt, Germany. The ToFD detector is able to detect heavy-ion residues of all charges at relativistic energies with a relative energy precision σΔE/ΔE of up to 1% and a time precision of up to 14 ps (sigma). Together with an
Background: Celiac disease (CD) is an autoimmune disease leading to gastrointestinal symptoms and mineral deficiencies. The pathogenetic mechanisms, besides the clear HLA association, are elusive. Among environmental factors infections have been proposed. Covid-19 infection results in a systemic inflammatory response that often also involves the gastrointestinal tract. The aim of the present study
Multi-gigawatt-scale hydrogen production by water electrolysis is central in the green transition when it comes to storage of energy and forming the basis for sustainable fuels and materials. Alkaline water electrolysis plays a key role in this context, as the scale of implementation is not limited by the availability of scarce and expensive raw materials. Even though it is a mature technology, th
This paper introduces the use of a multi-zone modelling approach for analysing smoke spread in tunnels. The approach suggested in this paper is based on an existing model, i.e., the Multi-Zone Fire model developed for large spaces. The Multi-Zone Fire model has been adapted and modified for tunnel fire scenarios by including features that consider longitudinal ventilation flow, tunnel gradient and
INTRODUCTION: Treatment efficacy of reflex syncope is mainly related to the mechanism underlying syncope rather than its etiology or clinical presentation. The predominant mechanism underlying reflex syncope can be assigned to hypotensive or to bradycardic phenotypes.AREAS COVERED: Methodology and diagnostic criteria of the most useful tests for the identification of hypotensive and bradycardic ph
This themed journal issue provides many examples of ways forward in the study of death and memory in the Viking world. While all contributions demonstrate that there are exciting new ways to study remains from funerary contexts that focus on different forms of citation involving material culture and monuments, this article will very briefly discuss dimensions that have not been addressed here. Spe
In pre-industrial Europe, many thousands of ‘middle-class’ individuals retired by purchasing a corrody: a contract allowing them life-long food and lodging, usually by spending their remaining years in a hospital. Given that people usually struggle to prepare for the later stages of life, this article asks whether corrodies were priced in line with the market. We study institutions that specialize
FLASH radiotherapy is a novel technique that has been shown in numerous preclinical in vivo studies to have the potential to be the next important improvement in cancer treatment. However, the biological mechanisms responsible for the selective FLASH sparing effect of normal tissues are not yet known. An optimal translation of FLASH radiotherapy into the clinic would require a good understanding o
