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The development of genetic counseling in Sweden in the field of medical genetics emerged in the 1950s, at the department of medical genetics at Uppsala University. The head of department, Jan Arvid Böök, a member of the WHO expert committee on Human Genetics, early realized the importance of studies in broadly distributed genetic diseases, along with genetic counseling. In the 1950s, at the same tThe development of genetic counseling in Sweden in the field of medical genetics emerged in the 1950s, at the department of medical genetics at Uppsala University. The head of department, Jan Arvid Böök, a member of the WHO expert committee on Human Genetics, early realized the importance of studies in broadly distributed genetic diseases, along with genetic counseling. In the 1950s, at the same t

Fire frequency is changing globally and is projected to affect the global carbon cycle and climate. However, uncertainty about how ecosystems respond to decadal changes in fire frequency makes it difficult to predict the effects of altered fire regimes on the carbon cycle; for instance, we do not fully understand the long-term effects of fire on soil carbon and nutrient storage, or whether fire-dr

Objective: Cancer and its treatment in childhood and young adulthood can cause hypogonadism, leading to increased risk of long-term morbidity and mortality. The aim of this study was to evaluate the risk of presenting with biochemical signs of hypogonadism in testicular cancer survivors (TCS) and male childhood cancer survivors (CCS) in relation to the type of treatment given. Design: Case-control

Global warming is driving environmental change in the Arctic. However, our current understanding of this change varies strongly among different environmental disciplines and is limited by the number and distribution of field sampling locations. Here, we use a quantitative framework based on multivariate statistical modeling to present the current state of sampling across environmental disciplines

Episodic memories typically comprise multiple elements. A defining characteristic of episodic retrieval is holistic recollection, i.e., comprehensive recall of the elements a memorized event encompasses. A recent study implicated activity in the human hippocampus with holistic recollection of multi-element events based on cues (Horner et al., 2015). Here, we obtained ultra-high resolution function

OBJECTIVE In type 2 diabetes, insulin resistance and progressive b-cell failure require treatment with high insulin doses, leading to weight gain. Our aim was to study whether a three-meal diet (3Mdiet) with a carbohydrate-rich breakfast may upregulate clock gene expression and, as a result, allow dose reduction of insulin, leading to weight loss and better glycemic control compared with an isocal

In this study, a global vegetation model (LPJ-GUESS) is forced with spatial information (Nomenclature of Units for Territorial Statistics (NUTS) 2 level) of land-use intensity change in the form of nitrogen (N) fertilization derived from a model chain which informed the Common Agricultural Policy Regionalized Impact (CAPRI) model. We analysed the combined role of climate change and land-use intens

The important role of fire in regulating vegetation community composition and contributions to emissions of greenhouse gases and aerosols make it a critical component of dynamic global vegetation models and Earth system models. Over 2 decades of development, a wide variety of model structures and mechanisms have been designed and incorporated into global fire models, which have been linked to diff

It is projected that forest disturbances, such as insect outbreaks, will have an increasingly negative impact on forests with a warmer climate. These disturbance events can have a substantial impact on forests' ability to absorb atmospheric CO2, and may even turn forests from carbon sinks into carbon sources; hence, it is important to develop methods both to monitor forest disturbances and to quan

Carbon release from the North Pacific in glacial-interglacial cycles has been mainly linked to the North Pacific Intermediate Water (NPIW) formation and associated carbon/nutrient water upwelling and biological productivity changes. However, relationship between NPIW and atmospheric CO2 change in the early interglacial remains unclear. Here we report a high-resolution sediment record of NPIW evolu

During 2010-2013, we investigated the effects of stump harvesting on greenhouse gas (GHG) fluxes of carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) with the flux-gradient technique at four experimental plots in a hemiboreal forest in Sweden. All plots were clear-cut and soil scarified and two of the plots were additionally stump harvested. The two clear-cut plots served as control plot

Remote sensing-based models are an adequate tool to estimate carbon dioxide (CO2) uptake by terrestrial ecosystems, and to upscale the results from ecosystem to regional or global scales. In this study we compare three models driven by Sentinel-2 derived vegetation indices together with eddy covariance (EC) measured CO2 flux and radiation data in order to estimate gross primary production (GPP) in

The Integrated Carbon Observation System Research Infrastructure aims to provide long-Term, continuous observations of sources and sinks of greenhouse gases such as carbon dioxide, methane, nitrous oxide, and water vapour. At ICOS ecosystem stations, the principal technique for measurements of ecosystem-Atmosphere exchange of GHGs is the eddy-covariance technique. The establishment and setup of an

Research infrastructures play a key role in launching a new generation of integrated long-Term, geographically distributed observation programmes designed to monitor climate change, better understand its impacts on global ecosystems, and evaluate possible mitigation and adaptation strategies. The pan-European Integrated Carbon Observation System combines carbon and greenhouse gas (GHG; CO2, CH4, N

Background: To investigate changes in knee 3D bone shape over the first 5 years after acute anterior cruciate ligament (ACL) injury in participants of the randomized controlled KANON-trial. Methods: Serial MR images over 5 years from 121 young (32 women, mean age 26.1 years) adults with an acute ACL tear in a previously un-injured knee were analyzed using statistical shape models for bone. A match

The importance of semi-arid ecosystems in the global carbon cycle as sinks for CO 2 emissions has recently been highlighted. Africa is a carbon sink and nearly half its area comprises arid and semi-arid ecosystems. However, the

Miniaturized thermal infrared (TIR) cameras that measure surface temperature are increasingly available for use with unmanned aerial vehicles (UAVs). However, deriving accurate temperature data from these cameras is non-trivialsince they are highly sensitive to changes in their internal temperature and low-cost models are often not radiometrically calibrated. We present the results of laboratory a

Temperature is a key constraint on ecosystem respiration but is typically measured at only one or a few points across a study site. Given the exponential relationship between temperature and respiration, small differences in temperature across a heterogeneous ecosystem may result in large differences in respiration fluxes. These differences are not captured in current respiration models which use

The ongoing development of the Global Carbon Project (GCP) global methane (CH4) budget shows a continuation of increasing CH4 emissions and CH4 accumulation in the atmosphere during 2000–2017. Here, we decompose the global budget into 19 regions (18 land and 1 oceanic) and five key source sectors to spatially attribute the observed global trends. A comparison of top-down (TD) (atmospheric and tran