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CCND1 amplification results in cyclin D1 overexpression. However, other unidentified genetic mechanisms contribute to enhanced gene expression. In the present study, 32 squamous cell carcinoma of the head and neck (SCCHN) were investigated regarding chromosomal abnormalities involving 11q13 by cytogenetic analysis, genomic CCND1 amplification by differential PCR and FISH, and cyclin D1 expression
Background: A study was undertaken to investigate the sociodemographic distribution of workplace exposure to environmental tobacco smoke (ETS) in a Swedish working population sample. Methods: 8,270 individuals were assessed by questionnaire in the Scania Public Health Survey. The influence of sociodemographic factors on ETS exposure at work was investigated by multivariable regression analysis. Re
PURPOSE: A new type of liposomal liver-specific contrast medium (CM) in CT was studied, and the results were compared with those obtained with Mn-DPDP, a paramagnetic hepatobiliary CM, in MR imaging. The contrasts of normal liver tissue to tumorous tissue and the importance of the CM for tumour detection in the 2 modalities were studied in a rabbit tumour model. CT and T1-weighted pre- and postcon
Empowerment has become a widespread concept in various social policy contexts referring to different marginalized groups. Empowerment has also been focused within the mental health field although little empirical research exists. The aim of the present study was to investigate internal consistency and construct validity of the Swedish version of an empowerment scale developed for people with a men
Nanoparticles in biological fluids almost invariably become coated with proteins that may confer nanomedical and nanotoxicological effects. Understanding these effects requires quantitative measurements using simple systems. Adsorption of HSA to copolymer nanoparticles of varying hydrophobicity and curvature was studied using ITC, yielding stoichiometry, affinity, and enthalpy changes upon binding
Popular Abstract in Swedish Stroke (även kallat slaganfall) är den tredje vanligaste dödsorsaken efter hjärtsjukdom och cancer i stora delar av världen. Strokesjukdomen består av blodpropp (hjärninfarkt), blödning i hjärnan (intracerebral blödning) eller blödning i dess hinnor (subaraknoidal blödning). Stroke definieras enligt WHO som snabbt påkomna neurologiska symptom (t.ex. förlamning, talsvåriBackground: Stroke is a major cause of death and disability. Investigations of the epidemiological trends for stroke might result in better understanding of stroke pathogenesis and prevention. Methods: The trends of first-ever stroke incidence and survival over 3 time periods (1983-85, 1993-95 and 2001/2002) in Lund-Orup health care district were studied. The first 2 study periods were retrospect
3,4-Dihydroxyphenyl-(L)-alanine ((L)-DOPA)-induced dyskinesia is associated with molecular and synaptic plasticity in the basal ganglia, but the occurrence of structural remodeling through cell genesis has not been explored. In this study, rats with 6-hydroxydopamine lesions received injections of the thymidine analog 5-bromo-2'-deoxyuridine (BrdU) concomitantly with (L)-DOPA for 2 weeks. A large
BACKGROUND: To describe the frequency, in some European populations, of the World Health Organisation (WHO) defined metabolic syndrome and to compare the frequency of this syndrome with an alternative definition for non-diabetic subjects, called the insulin resistance syndrome proposed by the European Group for the Study of Insulin Resistance (EGIR). METHODS: Investigators of eight European studie
We have examined the ability of KW-6002, an adenosine A2a antagonist, to modulate the dyskinetic effects of l-DOPA in 6-hydroxydopamine-lesioned rats. In animals rendered dyskinetic by a previous course of l-DOPA treatment, KW-6002 did not elicit any abnormal involuntary movements on its own, but failed to reduce the severity of dyskinesia when coadministered with l-DOPA. A second experiment was u
Popular Abstract in Swedish I den här doktorsavhandlingen presenteras ett datorprogram som utvecklats för att simulera och utvärdera biotekniska processer, där flera processteg kan vara integrerade. Speciellt har en process för framställning av mjölksyra från vetemjöl studerats. Mjölksyra har traditionellt använts i kemi-, läkemedels- och livsmedelsindustrin som t.ex. råvara, surgörare eller konseBiotechnical processes are often integrated to increase productivity and yield. It is difficult to predict the effects of process integration and to find optimum conditions for the process. A valuable tool for the evaluation of a complete process is mathematical modelling. In this thesis, a computer program developed for simulation and optimisation of integrated biotechnical processes is presented
The electronic structure of high-quality CrO2(100) films was investigated by means of x-ray absorption and resonant photoemission spectroscopy at the 2p-3d excitation threshold. The obtained binding energy of the occupied Cr 3d states is in agreement with the results predicted within the local spin-density approximation using the dynamical mean-field theory [L. Craco , Phys. Rev. Lett. 90, 237203
The relation between the isoform distribution of the myosin 17 kDa essential light chain (LC17) and the mechanical properties of smooth muscle was investigated. The relative content of the basic (LC17b) and acidic (LC17a) isoelectric variants of the 17 kDa myosin light chain was determined in different mammalian smooth muscle tissues. The relative content of LC17b varied between muscles: rabbit re
In the present study the incidence of reflux, stricture formation and changes in glomerular filtration rate in patients with the submucosal tunnel or the Camey-Le Duc technique of ureteric implantation into the caecum/detubularized right colon used for continent cutaneous diversion/orthotopic bladder substitution was investigated. Reflux was found in two renal units and ureterointestinal stenosis
PURPOSE: The aim of this study was to investigate the outcome of aortic valve replacement (AVR) and the effect on quality of life in patients aged over 85 who had symptomatic aortic stenosis. METHODS: We performed a retrospective analysis of 21 patients, aged 85-91 years (mean age 86.5), who underwent AVR, 10 of whom underwent concomitant coronary artery bypass grafting (CABG) between 1989 and 199
Popular Abstract in Swedish Denna avhandling behandlar utvecklingen av den norsk-svenska freden mellan 1905-1940. Efterhand kom denna relation att närma sig Stabil Fred—ett förhållande karaktäriserat av avsaknaden av militärt våld, hot om militärt våld, och förväntningar på hot om militärt våld. Utvecklingen mot Stabil Fred smammanfaller delvis med den svenska demokratiseringen, och författaren uThis study concerns the development of Stable Peace between states in the modern anarchical international system. As a starting point for the inquiry the author argues that the prevalence of this type of interstate relationships—characterized by the mutual expectations that neither military violence nor threats thereof will be employed—may be seen as a fundamental challenge to the validity of prev
