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There is an increasing need for new biomarkers to improve prediction of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D). We aimed to identify blood-based epigenetic biomarkers associated with incident CKD and develop a methylation risk score (MRS) predicting CKD in individuals with newly diagnosed T2D. DNA methylation was analyzed epigenome wide in blood from 487 individuals

X-ray ptychography provides the highest resolution non-destructive imaging at synchrotron radiation facilities, and the efficiency of this method is crucial for coping with limited experimental time. Recent advancements in multi-beam ptychography have enabled larger fields of view, but spatial resolution for large 3D samples remains constrained by their thickness, requiring consideration of multip

Oxygen-defective metal oxides like cerium oxides exhibit giant electrostriction and field-induced piezoelectricity due to a dynamic electrosteric interplay between oxygen defects, V O ⋅ ⋅ , and the fluorite lattice. While such mechanisms are generally attributed to oxygen vacancies, recent results also highlight that trapped cationic defects, Ce Ce ′ , i.e. small polarons, can contribute to the el

The X-ray flux from X-ray free-electron lasers and storage rings enables new spatiotemporal opportunities for studying in-situ and operando dynamics, even with single pulses. X-ray multi-projection imaging is a technique that provides volumetric information using single pulses while avoiding the centrifugal forces induced by conventional time-resolved 3D methods like time-resolved tomography, and

Due to the emergence of SMS messages, the significance of effective text entry on limited-size keyboards has increased. In this paper, we describe and discuss a new method to enter text more efficiently using a mobile telephone keyboard. This method, which we called HMS, predicts words from a sequence of keystrokes using a dictionary and a function combining bigram frequencies and word length. We

Design, as a principal function for innovation in business, governments, and other social units, can play a critical role in creating sustainable solutions. While current debates acknowledge expanding design scope and continuing competencies that distinctively qualify design professionals for undertaking sustainability challenges, design schools in higher education institutions are struggling to m

As the world’s fifth largest oil producer, and holder of the third largest proven oil reserves, Canada is poised to significantly impact future global carbon emissions. The present government, under the leadership of Liberal Prime Minister Justin Trudeau, is seeking to simultaneously position itself as a global climate leader while supporting the exploitation of Canada’s extensive bitumen oil rese

Entrepreneurs often face the need to make quick decisions under uncertainty. To cope with this pressure, they may develop cognitive biases such as the illusion of control, where they overestimate their influence over outcomes, and the belief in the law of small numbers, where they rely on limited information to draw conclusions. While these biases are highly relevant in entrepreneurship, there is

The PRIMARY score was implemented in Prostate Cancer Molecular Imaging Standardized Evaluation (PROMISE) version 2 to improve accuracy for the diagnosis of clinically significant prostate cancer using prostate-specific membrane antigen (PSMA) positron emission tomography (PET). We reviewed overall survival (OS) for patients who underwent PSMA PET for initial staging to evaluate the prognostic valu

A Nordic-Soviet programme was initiated in 1990 to evaluate the external and internal radiation exposure of the inhabitants of several villages in the Bryansk region of Russia. This area was one of the number of areas particularly affected by the nuclear accident at the Chernobyl Nuclear Power Plant in 1986. Measurements were carried out yearly until 1998 and after that more irregularly; in 2000,

In the research on two of the most prominent persons among those who rescued Jews from the Holocaust, Oskar Schindler and Raoul Wallenberg, a reappearing purpose has been to separate mythical, and therefore more or less false, elements in the story from the true, and implicit, academic historical writing. However, during the last decades, it has been obvious that history is not only, and sometimes

It is apparent that climate change is progressing, increasing the frequency of heavy rainfall events. In coastal areas, halocline formation caused by increased freshwater inflow can inhibit vertical mixing, reducing oxygen concentration in the bottom layer. The Ariake Sea, an inner bay in Japan with a large tidal range, has faced serious issues such as red tides and hypoxia. Previous studies

Fencing to exclude livestock is one of the effective strategies to passively reshape grassland ecosystem function, yet the dynamics of microbial community construction and their functional traits during restoration remain poorly understood. This study systematically sampled from various microhabitats (phyllosphere, litter, soil) within long-term fenced restoration areas, as well as areas with pers

Background: Treatment with antihypertensives in patients with advanced cancer is often continued until very late in the disease trajectory, despite a considerable risk of hypotension. Objectives: The aim of this study was to investigate the time of deprescribing of antihypertensive agents in patients with cancer receiving palliative care during their last year of life. The monitoring of blood pres

Ferroelectric thin films present a powerful platform for next-generation computing and memory applications. However, domain morphology and dynamics in buried ferroelectric stacks have remained underexplored, despite their importance for real device performance. Here, nanoprobe X-ray diffraction (nano-XRD) is used to image ferroelectric domains inside BiFeO3-based capacitors, revealing local disord

Toxin-antitoxin-chaperone (TAC) systems are three-part gene clusters encoding a toxin, antitoxin, and specialized SecB-like chaperone (SecB TA) with emerging roles in phage defense. To identify and classify SecB homologs and associated TACs across bacteria, we surveyed the full RefSeq database. Phylogenetic and gene neighborhood analyses reveal three major SecB subfamilies: two housekeeping group