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Microdosing is a new concept in drug development that-if implemented in the pharmaceutical industry-would mean that new drugs can be tested earlier in humans than done today. The human microdosing concept-or 'Phase 0'-may offer improved candidate selection, reduced failure rates in the drug development line and a reduction in the use of laboratory animals in early drug development, factors which w
Stochastic optimal power flow can provide the system operator with adequate strategies for controlling the power flow to maintain secure operation under stochastic parameter variations. One limitation of stochastic optimal power flow has been that only line flows have been used as security constraints. In many systems voltage stability and small-signal stability also play an important role in constrai
In this paper the sum of an orthogonal matrix and an outer product is studied, and a relation between the norms of the vectors forming the outer product and the singular values of the resulting matrix is presented. The main result may be found in Theorem 1.
This paper deals with the real-time implementation of feedback controllers. In particular, it provides an analysis of the stability property of closed-loop systems that include a controller that can sporadically miss deadlines. In this context, the weakly hard m-K computational model has been widely adopted and researchers used it to design and verify controllers that are robust to deadline misses
In this paper, bilateral teleoperation of multiple slaves coupled to a single master under scheduling communication is investigated. The sampled-data transmission between the master and the multiple slaves is fulfilled over a delayed communication network, and at each sampling instant, only one slave is allowed to transmit its current information to the master side according to some scheduling pro
Fitting a matrix of a given rank to data in a least squares sense can be done very effectively using 2nd order methods such as Levenberg-Marquardt by explicitly optimizing over a bilinear parameterization of the matrix. In contrast, when applying more general singular value penalties, such as weighted nuclear norm priors, direct optimization over the elements of the matrix is typically used. Due t
Handling of critical situations is an important part in the architecture of an autonomous vehicle. A controller for autonomous collision avoidance is developed based on a wary strategy that assumes the least tireroad friction for which the maneuver is still feasible. Should the friction be greater, the controller makes use of this and performs better. The controller uses an acceleration-vector ref
A push-pull oscillator topology that uses only one type of active device is proposed in this article. A magnetic transformer is leveraged to set positive feedback around a common-collector differential npn transistor pair, implementing the push-pull operation. This results in half the bias current for a given amplitude of oscillation, compared to more standard oscillator topologies. A thorough pha
We describe how the optimal dual controller for a discrete-time linear system can be found by approximately solving the corresponding Bellman equation using a neural network to represent the value function. We illustrate the method on an example with time-varying dynamics, where the new method is shown to give improved performance.
This paper concerns trajectory tracking control of attitude dynamics configured on SU(2). Inspired by a popular geometric tracking controller on SO(3), differential geometric tools are used to derive both continuous and discontinuous attitude controllers on the SU(2) manifold, relating these to preexisting controllers operating with imaginary quaternion errors. Additionally, a robustness result is
We exploit knowledge of linear substructure in the linear-regression Kalman filters (LRKFs) to simplify the problem of moment matching. The theoretical results yield quantifiable and significant computational speedups at no cost of estimation accuracy, assuming partially linear estimation models. The results apply to any symmetrical LRKF, and reductions in computational complexity are stated as a
We present a tracking controller for quadrotor UAVs which uses partial state information and filters measurement noise. We show uniform almost global and locally exponential asymptotic stability of the resulting closed-loop system, which implies robustness against bounded disturbances. We illustrate the performance of the controller by means of several numerical examples, including a complex loopi
This paper considers coordination control of double-integrator systems and proposes general control laws involving time-varying inputs. The nominal control input is weighted by time-varying (time-dependent or state-dependent) positive definite matrices, providing more freedoms in defining the control tasks. We present sufficient conditions to ensure the asymptotic convergence of double-integrator
Traditionally, automatic control techniques arose due to need for automation in mechanical systems. These techniques rely on robust mathematical modelling of physical systems with the goal to drive their behaviour to desired set-points. Decades of research have successfully automated, optimized, and ensured safety of a wide variety of mechanical systems. Recent advancement in digital technology ha
Modern computer systems consist of large number of entities connected through a shared resource. One such system is a video surveillance network consisting of a set of cameras and a network manager. The surveillance cameras capture a stream of images and transmit them to the manager over a shared constrained network. The central manager allocates bandwidth to the cameras in a fair manner using a t
We study the problem of controlling phase activations for signalized junctions in an urban transportation network using local feedback information consisting of measures of the queue-lengths at the incoming lanes of each junction. Our focus is on the validation and performance evaluation through micro-simulations of the recently proposed Generalized Proportional Allocation (GPA) controller. Previo
Q-design is a powerful method for designing approximately optimal LTI controllers and assessing the achievable control performance. Unfortunately, numerical issues are often encountered in Q-design which limits its applicability. This paper warns about two numerical pitfalls in Q-design when using H 2 costs and Laguerre-type basis functions.
Over the past years, interest in classifying drivers' behavior from data has surged. Such interest is particularly relevant for car insurance companies who, due to privacy constraints, often only have access to data from Inertial Measurement Units (IMU) or similar. In this paper, we present a semi-supervised learning solution to classify portions of trips according to whether drivers are driving a
