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OBJECTIVES: The efficacy of long-term opioid therapy (LTOT) in treating patients with chronic non-cancer pain (CnCP) is questionable, and the potential risks of adverse effects are well established. The aims were as follows: (1) compare characteristics in patients exposed to LTOT vs non-exposed. (2) Regarding opioid-exposed patients, describe characteristics of patients with risk factors for opioi
One of the aims of PhD students’ socialisation is for them to accept the norms of the teaching culture and to be fully engaged with and accepted by the university teaching community. However, when PhD students enter universities, they do not necessarily accept all of the university teaching community’s cultural norms, nor do they all experience acceptance by the community. This phenomenographic st
Background: Endocrine disrupting chemicals (EDCs) can cross the placenta and thereby expose the fetus, which may lead to developmental consequences. It is still unclear which chemicals are of concern regarding neurodevelopment and specifically behaviour, when being exposed to a mixture. Objective: The objective is to determine associations between prenatal exposure to EDCs and behavioural difficul
This study examines how one may detect Parkinson’s disease (PD) by analyzing voice recordings made with a mobile phone. The key objectives include creating a model that ensures fair and unbiased predictions while maintaining interpretability that is consistent with the existing literature on PD. We introduce a novel group-wise scaling method to address typical age and biological sex biases in the
Ti (C, N) based cermet materials are predominantly used in continuous finishing applications of metal cutting due to their high hardness, excellent resistance to oxidation and high chemical stability. However, their application in interrupted cutting like milling are limited due to their brittle-like failure due to low fracture toughness. In this work, alternative binder systems such as Co-Ni and
Seeleyosaurus guilelmiimperatoris is an early-diverging plesiosauroid from the lower Toarcian (Lower Jurassic) of the Posidonienschiefer Formation (Posidonia Shale) of Holzmaden, southwestern Germany. It is known from almost complete skeletons of two osteologically mature individuals, the holotype and a referred specimen that was largely destroyed during World War II. Although well-preserved and s
BACKGROUND: In 2013, it was discovered that a subset of the population in Ronneby, Sweden was exposed to high levels of perfluorinated compounds (PFAS) from drinking water that had been provided by the local Brantafors waterworks and was contaminated by fire-fighting foam from a nearby airport. The start and time-course of population exposures are not known.OBJECTIVE: To investigate the start of P
Background and Aims The long-term outcomes of percutaneous coronary intervention (PCI) vs. coronary artery bypass grafting (CABG) in patients with non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel disease remain debated. Methods The Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies registry
In this article, we propose a restricted gamma ridge regression estimator (RGRRE) by combining the gamma ridge regression (GRR) and restricted maximum likelihood estimator (RMLE) to combat multicollinearity problem for estimating the parameter (Formula presented.) in the gamma regression model. The properties of the new estimator are discussed, and its superiority over the GRR, RMLE and traditiona
The node of Ranvier is the key element in saltatory conduction along myelinated axons, but its specific protein organization remains elusive in the human species. To shed light on nanoscale anatomy of the human node of Ranvier in health and disease, we assessed human nerve biopsies of patients with polyneuropathy by super-resolution fluorescence microscopy. We applied direct stochastic optical rec
Brent geese, Branta bernicia hrota, were equipped with satellite transmitters on a spring stop-over site in Iceland. The brent geese deposit heavy fuel reserves for long-distance flights across the high Greenland ice-cap to breeding destinations in north Canada. Satellite tracking of brent geese on this journey serves the twofold purpose of testing specific predictions about: (i) size-dependent po
Background: Several studies have investigated the association between metabolic syndrome (MetS) and physical activity (PA). However, further research is needed using objective measures of PA in free-living conditions, while also accounting for the time-variant nature of MetS. This study aimed to: (1) investigate the association between wearable device-measured step count and 5-year MetS incidence
Sudden Unexpected Death in Epilepsy (SUDEP) is a leading cause of mortality among individuals with epilepsy, particularly those with drug-resistant forms. This review explores the complex multisystem mechanisms underpinning SUDEP, integrating recent findings on brain, cardiac, and pulmonary dysfunctions. Background/Objectives: The main objective of this review is to elucidate how seizures disrupt
Students’ possibilities to interact with peers have reduced drastically during the emergency transition to online teaching due to the Covid-19 pandemic. Students report on decreased motivation and other study related issues; hence, there is a need to better understand the effects of decreased interaction. The aim of the present exploratory study was to document changes in student networks, in rela
Bivalves are considered mainly filter-feeding organisms; they remove suspended particles including phytoplankton, zooplankton, and bacteria from the water column. Moreover, some bivalves can also feed via pedal-feeding, which is the uptake of organic matter from the sediment using cilia on the foot. Diplodon parallelopipedon is a native bivalve from South America, which can obtain their foo
Objective: To investigate the association of different aspects of cognitive impairment, depression and anxiety with walking difficulties in daily life in persons with mild PD.Background: Walking difficulties in daily life are common among persons with Parkinson’s disease (PD) and may cause falls and near falls, limitations in activity, restrictions in participation and decrease in quality of life.
