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BACKGROUND AND OBJECTIVES: Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by 3 core symptom complexes: parkinsonism, cerebellar syndrome, and dysautonomia. Recent Movement Disorder Society (MDS) criteria allow for the clinical diagnosis of MSA based solely on motor symptoms, without requiring dysautonomia. This study aimed to evaluate the frequency and disease trajecto
The Chambolle–Pock method is a versatile three-parameter algorithm designed to solve a broad class of composite convex optimization problems, which encompass two proper, lower semicontinuous, and convex functions, along with a linear operator L. The functions are accessed via their proximal operators, while the linear operator is evaluated in a forward manner. Among the three algorithm parameters
Explicit finite element schemes are extensively used in industrial applications characterised by elevated strain rates and complex contact interactions. A central challenge in such simulations is the achievement of mesh-independent results while accurately capturing damage localisation and evolution. Gradient-enhanced damage models provide a robust regularisation framework. However, using a microm
Background: The dairy industry has gradually adopted cutting-edge technology in the past few years. This review explores the evolution and interventions of Artificial Intelligence (AI), Machine Learning (ML), and Industry 4.0 in the dairy industry through a systematic literature review and bibliometric analysis. Methods: The Web of Science, Scopus, etc. databases were used for bibliometric analysi
BACKGROUND: Patients receiving intraoperative ventilation during general anesthesia often have low end-tidal CO2 (etCO2). We examined the association of intraoperative etCO2 levels with the occurrence of postoperative pulmonary complications (PPCs) in a conveniently-sized international, prospective study named 'Local ASsessment of Ventilatory management during General Anesthesia for Surgery' (LAS
The impact of variations in the three-dimensional structure of the genome has been recognized, but solid cancer tissue studies are limited. Here, we performed integrated deep Hi-C sequencing with matched whole-genome sequencing, whole-genome bisulfite sequencing, 5-hydroxymethylcytosine (5hmC) sequencing and RNA sequencing across a cohort of 80 biopsy samples from patients with metastatic castrati
In this article, we use a crowd theoretical perspective to look at student crowds and how they have been managed through various subdivisions of student housing. How has the student cohort been territorialised and divided into entities according to differences in group sizes, gender, family constellations, etc., and how has housing played a role in these social differentiations? Using the history
Paper on Charles XII as he was portrayed by Gösta Ekman the older in the film Charles XII (1925).
IMPORTANCE: Key information is often omitted from pediatric randomized controlled trial (RCT) protocols, including details on dose adjustments of interventions based on age, body surface area, or weight; developmental appropriateness of trial outcome measures and processes; or strategies to minimize participants' anxiety and pain. These deficiencies impair the planning and implementation of potent
INTRODUCTION: Parents can act as important agents of change and support for healthy childhood growth and development. Studies have found that parents may not be able to accurately perceive their child's weight status. The purpose of this study was to measure parental perceptions of their child's weight status and to identify predictors of potential parental misperceptions.METHODS: We used data fro
Genetics as a science has roots in studying phenotypes of relatives, but molecular approaches facilitate direct measurements of genomic variation between individuals. Agricultural and human biomedical research are both emphasizing genotype-based instruments, such as polygenic scores, but unlike in agriculture, there is an emerging consensus that family variables act nearly independently of genotyp
Infections caused by anaerobes are common in children. However, limited data are available on bloodstream infections caused by these bacteria in Europe. A multicentre retrospective observational study was conducted over a 4-year period (2020–2023) across 44 European hospitals to analyze all anaerobes isolated from blood cultures. The study examined the epidemiology and antimicrobial resistance pro
The development and manufacturing process for Integrated Circuits (ICs) has become complex and globally distributed. System integrators use a mix of custom made logic with third-party Intellectual Property (IP) blocks, untrusted software tools, and external actors for manufacturing, post-production test, and validation. The many untrusted actors involved throughout the IC’s lifetime become a secur
