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Purpose: Previous studies using FLASH radiotherapy (RT) in mice showed a marked increase of the differential effect between normal tissue and tumors. To stimulate clinical transfer, we evaluated whether this effect could also occur in higher mammals. Experimental Design: Pig skin was used to investigate a potential difference in toxicity between irradiation delivered at an ultrahigh dose rate call
A large number of experiments in successive tests of episodic memory have focused on an experimental paradigm called recognition failure of recallable words. In this paradigm, a cued recall test follows a recognition test. Large amounts of data have revealed a lawful moderate dependence between recognition and cued recall. TECO (Sikström, 1996b), a general connectionist theory of memory, has been
Some of the objections to life-extension stem from a concern with overpopulation. I will show that whether or not the overpopulation threat is realistic, arguments from overpopulation cannot ethically demand halting the quest for, nor access to, life-extension. The reason for this is that we have a right to life, which entitles us not to have meaningful life denied to us against our will and which
Incorporating time as a unit of analysis can enrich the study of agency by showing the specific ways in which actors are temporally constrained when responding to economic disturbances. In this paper, this is done by examining how the behavior of actors is affected by timing norms such as term limits that may be associated with an actor's position, as for example, an elected mayor or university vi
The 1.87–1.84 Ga Black Hills dike swarm of the Kalahari craton (South Africa) is coeval with several regional magmatic provinces used here to resolve the craton’s position during Columbia assembly. We report a new 1850 ± 4 Ma (U-Pb isotope dilution–thermal ionization mass spectrometry [ID-TIMS] on baddeleyite) crystallization age for one dike and new paleomagnetic data for 34 dikes of which 8 have
In the last decades, the substantial technical progress in radiation oncology offered the opportunity for more accurate planning and delivery of treatment. At the same time, the evolution of systemic treatment and the advent of modern diagnostic tools allowed for more accurate staging and consequently a safe reduction of radiotherapy (RT) target volumes and RT doses in the treatment of lymphomas.
Introduction: This study investigated the diagnostic and disease-monitoring potential of plasma biomarkers in mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia and cognitively unimpaired (CU) individuals. Methods: Plasma was analyzed using Simoa assays from 99 CU, 107 MCI, and 103 AD dementia participants. Results: Phosphorylated-tau181 (P-tau181), neurofilament light, amyloid-
This thesis is ta study of the intersection between dark green spirituality and the green movement in relation to climate change and ecological crisis, and it explores how some ecologically concerned people try to orientate themselves in facing the challenges and especially the role of spirituality in this context. The study is set in the period 2009–2015, and it is based in fieldwork conducted i
Within the framework Solar Heating and Cooling Programme of the International Energy Agency Task 51 “Solar Energy in Urban Planning”, case studies from Norway, Sweden, and Denmark were collected and analyzed through a comparative approach. The cases were first classified based on their urban characterization (existing and new urban areas) and then compared within the same country or in a cross-cou
The comprehensive prehistoric settlement Uppåkra, lasting over a millennium,raises questions on how food supplies and local communities were agriculturally organized. Recent investigations of archaeobotanical remains from theregional center Uppåkra and several surrounding settlements have contributed to new aspects of their agricultural relations. New patterns in consumption show that through i
I sitt tidiga verk Om empatins problem (Zum Problem der Einfühlung) försöker Edith Stein ”specificera empatins speciellt intentionella karaktär” (Zahavi 2001,158). Ett övergripande mål för Stein är att finna de element som konstituerar en individ som en ”annan” för oss. Ett liknande syfte återfinns i skrifter som koncipierades delvis under samma tid på ett annat kunskapsområde, skådespelarkonstensIn her early work On the problem of empathy, (Zum Problem der Einfühlung), Edith Stein attempts to ´specify the particular intentional character of empathy´ (Zahavi 2001, 158). An overall aim for Stein is to find out the elements of what constitutes an individual as an ´other´ for us. A similar aim is present in writings that were conceived partly at the same time within another field of knowledge
This introduction presents an overview of key concepts discussed in the subsequent chapters of this book. The book presents a typology of experimentation distinguishing between niche experiments, social experiments, transition experiments, grassroots experiments and sustainability experiments, and proposes an encompassing definition of experimentation. It highlights the connections between greenin
Error estimation and data fusion are critical to improving the accuracy of global model- and satellite-based precipitation products for practical applications. However, they face challenges over vast areas of the world due to limited ground observations. Triple collocation (TC) method can overcome this limitation and provide an efficient way for error estimation without the “ground truth” and thus
Dietary fiber is considered a strong intestinal protector, but we do not know whether dietary fiber protects against the long-lasting mucosal damage caused by ionizing radiation. To evaluate whether a fiber-rich diet can ameliorate the long-lasting pathophysiological hallmarks of the irradiated mucosa, C57BL/6J mice on a fiber-rich bioprocessed oat bran diet or a fiber-free diet received 32 Gray i
Current theories of the glymphatic system (GS) hypothesize that it relies on cerebrospinal fluid (CSF) circulation to disseminate growth factors and remove metabolic waste from the brain with increased CSF production and circulation during sleep; thereby, linking sleep disturbance with elements of CSF circulation and GS exchange. However, our growing knowledge of the relations between sleep, CSF,
Obesity is associated with an increased risk of breast cancer, which is the most common cancer in women worldwide (excluding non‐melanoma skin cancer). Furthermore, breast cancer patients with obesity have an impaired prognosis. Adipose tissue is abundant in the breast. There-fore, breast cancer develops in an adipose‐rich environment. During obesity, changes in the local environment in the breast
There is a widespread perception that present-day Nordic egalitarianism is the outcome of a long historical continuity, where the strong political position of peasant farmers and weak feudalism were marking characteristics of pre-industrial society. However, little empirical evidence so far exists on the distribution of income for the early modern period. In this paper, we draw on the schedule an
Across the developing world the preceding decade or so has witnessed a profound reconfiguration of the political economy of urban policy. This new policy environment is driven by globalization, the neo-liberal macro-economic package of 'market enablement' and structural adjustment, which now form the dominant development paradigm. The consequences of this approach for urban development agendas and
