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A heat transfer and sub-grid chemical reaction kinetic model for solid phase combustion of a charring polymer is presented based on distributed reactivity modeling approach. The model is used to compute flammability parameters of a polymer sheet of a given thickness to simulate test results of a cone calorimeter experiment. Comparison of model simulations with cone calorimeter test data shows that
Projectile Coulomb excitation experiments were performed at HIE-ISOLDE at CERN with the radioactive ion beams of 140Nd and 142Sm. Ions with an energy of 4:62 MeV/A were impinging on a 1.45 mg/cm2 thick 208Pb target. The γ-rays depopulating the Coulomb-excited states were recorded by the HPGe-array MINIBALL and scattered particles were detected by a double-sided silicon strip detector. Experimental
BACKGROUND: Fast-track referral is an increasingly used method for diagnostic evaluation of patients suspected of having cancer. This approach is challenging and not used as often for patients with only nonspecific symptoms. In order to expedite the diagnostics for these patients, we established Sweden's first Diagnostic Center (DC) focusing on outcomes related to diagnoses and diagnostic time int
Mucosal Toll-like receptors (TLRs) respond to pathogens, but remain inert to the indigenous flora, suggesting that the TLRs can receive pathogen-specific signals. For example, TLR4 signalling is activated in CD14-negative epithelial cells by P-fimbriated, uropathogenic Escherichia coli, but not by lipopolysaccharide. The fimbriae use glycosphingolipids as recognition receptors and there is release
Poly(arylene ether sulfone)s have been functionalised with alkyl side chains carrying phosphonic acid and bis(phosphonic acid) in order to investigate their properties as membrane materials. The phosphonated and bisphosphonated polymers were synthesised via lithiation of poly(arylene ether sulfone)s, followed by reactions with triethyl 3-phosphonopropionate and tetraisopropyl vinylidenediphosphona
A Yersinia PCR-Compatible Enrichment (YPCE) medium was developed, which removes the necessity for sample pretreatment before PCR-based detection of Yersinia enterocolitica. The medium was designed through a sequence of independent screening and factorial design experiments to study the PCR inhibition and growth characteristics of medium components. The compatibility of the YPCE medium was evaluate
The feasibility and scalability of extraction in detergent-based aqueous two-phase systems for the separation of proteins from culture broth is demonstrated. At the same time the large-scale production of a fusion protein and the influence of cultivation scale on the efficiency of separation were investigated. An amphiphilic fusion protein EGIcore-HFBI was chosen, consisting of the catalytic core
Previous studies have shown increased cardiovascular mortality as late side effects in Hodgkin lymphoma (HL) patients. This study identifies stratifying risk factors for surveillance and defines concepts for a clinical feasible and noninvasive prospective protocol for intervention of cardiovascular side effects. HL patients diagnosed between 1965 and 1995 (n = 6.946) and their first-degree relativ
When load balancing data centres with all serversactive to serve jobs, the result can be excessive energy usage. Onthe other hand, using dynamic server provisioning, the numberof servers that serve requests can be reduced by turning off idleservers and thereby save energy. However, such a scheme, usuallyincreases the risk of instability of server queues. In this work,we analyze the trade-off betwe
PURPOSE: To implement an aggregation method in Matlab for generating ActiGraph counts from raw acceleration recorded with an alternative accelerometer device and to investigate the validity of the method. METHODS: The aggregation method including the frequency band-pass filter was implemented and optimized based on standardized sinusoidal acceleration signals generated in Matlab and processed in t
Cell entry of Simian Virus 40 (SV40) involves caveolar/lipid raft-mediated endocytosis, vesicular transport to the endoplasmic reticulum (ER), translocation into the cytosol, and import into the nucleus. We analyzed the effects of ER-associated processes and factors on infection and on isolated viruses and found that SV40 makes use of the thiol-disulfide oxidoreductases, ERp57 and PDI, as well as
The financial position of the medical insurance system of Japanese government has been worsened recently, and thus the Ministry of Health, Labor and Welfare has prompted the medical reforms to reconstruct the financial balance of the medical insurance system. As one of these efforts, a fixed payment system for medical services based on “DPC” (Diagnosis Procedure Combination) was introduced to a nu
This contribution presents a modeling and optimization method for multi-column counter-current purification (MCSGP) processes. The model is based on conventional column models and by using the symmetric and cyclic steady state characteristics of the process a single column analog model was developed. The model have been used for dynamic optimization of the MCSGP process. The optimization was based
User Generated Content (UGC) is projected to make up a significant part of the total Internet traffic in the future. As such, it will significantly contribute to the total cost for Internet traffic worldwide. Arguably, UGC is a suitable content type for which the Internet Service Providers (ISPs) can take initiative and enter the content delivery market. However, despite its significance, UGC cont
Objectives: To describe the process and outcomes of using a new evidence base to develop scientific guidelines that specify the type and minimum dose of exercise necessary to improve fitness and cardiometabolic health in adults with spinal cord injury (SCI). Setting: International. Methods: Using Appraisal of Guidelines, Research and Evaluation (AGREE) II reporting criteria, steps included (a) det
To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLADRB5 (odds ratio (
In all manufacturing processes, it is important to determine the costs and their distribution between different sequential processing steps. A cost equation based directly on the losses during manufacturing, such as rejection rate, stops and waste of workpiece materials, also provides a valuable aid in giving priority to various development activities and investments. The present work concerns how
Pepper spray (OC) is a policing tool aimed to prevent or stop aggressive behavior by quickly and temporarily incapacitate without injuring. To date, few studies have investigated OC’s operational usefulness and limitations. OC reduced violent behavior in 93% of the 936 incidents investigated. However, the operative range was often <2 m and it took between 3 and 5 s of spraying before obtaining eff
