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Anxiety disorders are common in children and adolescents, but access to evidence-based treatment is limited. Most clinical guidelines recommend stratified care, where less complex patients are offered low intensity interventions and complex patients more intensive options. Stepped care, where all patients initially receive low-intensity treatment, has gained traction due to its potential cost-effe
This Study Protocol article outlines the aims, theory, and methodology of a 4-year project that primarily seeks toenhance our understanding of the role of starting age and Extramural English. The project unravels the language proficiencyof individuals studying English as a foreign or second language (L2) who encounter substantial exposure to English outsideschool (extramural English, EE), but begiThis Study Protocol article outlines the aims, theory, and methodology of a 4-year project that primarily seeks to enhance our understanding of the role of starting age and Extramural English. The project unravels the language proficiency of individuals studying English as a foreign or second language (L2) who encounter substantial exposure to English outside school (extramural English, EE), but b
Recent studies provide insights about local agency in regional development. While acknowledging non-local actors and drivers, these studies have not systematically discussed the link between extra-regional relations and local agency. This paper first discusses three key arguments in the literature on extra-regional relations covering context-specific dependencies, strategic coupling and open innov
Background: Serially interconnected microfluidic devices enable advanced applications such as multi-step chemical processing and multi-organ-on-chip systems. However, managing these systems presents challenges due to interdependent fluid dynamics in their connecting channels, where even minor disturbances can propagate throughout the network, affecting overall system performance. Methods: This stu
Background: Available fluid biomarkers, neuroimaging techniques, and clinical assessments may enhance prediction of conversion to secondary progressive multiple sclerosis (SPMS). Objectives: : To identify robust real-world predictors of MS progression in the literature. Methods: : A systematic review was conducted in EMBASE. A total of 20,338 MS patients from 64 eligible studies were included. A p
Background: Multiple clinical practice guidelines and head computed tomography decision rules exist for emergency department (ED) triage of children with traumatic brain injury (TBI). These vary in structure, aim, target cohort, and outcomes, yet are used clinically in similar populations. We compared important clinical and practical characteristics of all major guidelines in a large, real-world p
Improving energy efficiency in agriculture is key to reducing environmental impact. Lighting in animal buildings is one of the most cost‐effective energy saving measures. Lighting retrofit offers a short payback period, enhances animal welfare and production, and aligns with regulations for phasing out fluorescent lighting. The purpose of this study was to investigate the energy-saving potential o
The feasibility of South Africa's just energy transition, as dictated by the speed of phasing out coal and scaling up renewables, will rest on a range of techno-economic, socio-political, and socio-technical factors. Interactions between these dimensions of the transition carry significant implications for energy justice. In response, this paper proposes the Just Transition Feasibility Framework (
The European Spallation Source is currently under construction in Lund, Sweden. Consisting of a linear accelerator delivering an unprecedented 5 MW proton beam to the spallation source, i.e. a rotating Tungsten disk, it will deliver high-flux neutron beams to multiple beamlines at which scientific experiments will be conducted in many scientific disciplines.To simulate the proton beam and for crea
Universities, operating at the intersection of state, market, and civil society, are increasingly called upon to address urgent global challenges, such as climate change, inequalities, and social injustice. This has given rise to hybrid roles for scholars, ranging from public intellectuals to policy advisers and academic entrepreneurs. Among these roles, scholar-activism stands out by explicitly a
We aimed to investigate the association between psychotropic drug use (proxy for psychological health) and Complex Regional Pain Syndrome (CRPS) type 1 and type 2 in upper and lower limbs. We also assessed the impact of demographic and socioeconomic factors. From a national record linkage database [4,706,821 individuals (25–64 years); CRPS type 1 = 809; type 2 = 225], prevalence ratios (PR), absol
Developing a robust decision analysis framework for selecting appropriate building envelope assemblies is essential to ensure moisture safety, energy efficiency, and sustainability. Recently, Bayat Pour et al. introduced the inutility decision analysis (IDA) method, which integrates moisture safety criteria with sustainability considerations, including economic and environmental aspects. This stud
Purpose: The sugar industry is always pressured to be suitable and enhance its operational effectiveness. Digital Twin (DT) has the potential to transform this industry. However, the lack of industry-specific Key Performance Indicator (KPI) frameworks makes it challenging to implement them. This study provides a hierarchical KPI model for DT adoption in the sugar sector, interconnecting the United
Background: Psychological resilience refers to a person's positive adaptation when faced with adversities, such as a breast cancer (BC) diagnosis. Highly resilient patients are more likely to regain stability and be protected from health conditions such as depression, anxiety, and posttraumatic stress disorder. We aimed to identify epigenetic markers that distinguish high- and low-resilient patien
Polyethylene glycol (PEG) is commonly used in the conservation of wooden artifacts, but its presence adversely affects the accuracy of radiocarbon dating. It is therefore critical to have robust methods for the removal of PEG from heritage materials. This paper presents the results of an experiment designed to test a protocol for the removal of low molecular-weight PEG-400 from conserved wood. We
Ulnar nerve entrapment at the elbow (UNE) is the second most common compression neuropathy in the upper limb. Immediate return-to-work (RTW) after surgery is seldom possible due to restrictions and recovery demands. We aimed to explore RTW after UNE surgery and investigate factors contributing to variations. A prospective study with patients undergoing primary UNE surgery was conducted. Treatment
Remission is emerging as a feasible treatment goal in moderate-to-severe asthma, driven by the success of biologic therapies in controlling inflammation and reducing exacerbations. Yet current definitions of remission—focused on symptom control, lung function, and corticosteroid reduction—lack precision, can only be ascertained retrospectively, and do not reflect the underlying mechanisms and path
Health-related quality of life (HRQoL) has been shown to predict overall survival (OS) in several different malignancies, but not in patients with small intestinal neuroendocrine tumours (siNET). We evaluated the influence of HRQoL on survival in patients with siNET. We included 85 patients with advanced siNET who completed the validated HRQoL instruments, EORTC QLQ-C30 and GI.NET21. We used Cox p
