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Recent studies provide insights about local agency in regional development. While acknowledging non-local actors and drivers, these studies have not systematically discussed the link between extra-regional relations and local agency. This paper first discusses three key arguments in the literature on extra-regional relations covering context-specific dependencies, strategic coupling and open innov
Background: Serially interconnected microfluidic devices enable advanced applications such as multi-step chemical processing and multi-organ-on-chip systems. However, managing these systems presents challenges due to interdependent fluid dynamics in their connecting channels, where even minor disturbances can propagate throughout the network, affecting overall system performance. Methods: This stu
Background: Available fluid biomarkers, neuroimaging techniques, and clinical assessments may enhance prediction of conversion to secondary progressive multiple sclerosis (SPMS). Objectives: : To identify robust real-world predictors of MS progression in the literature. Methods: : A systematic review was conducted in EMBASE. A total of 20,338 MS patients from 64 eligible studies were included. A p
Background: Multiple clinical practice guidelines and head computed tomography decision rules exist for emergency department (ED) triage of children with traumatic brain injury (TBI). These vary in structure, aim, target cohort, and outcomes, yet are used clinically in similar populations. We compared important clinical and practical characteristics of all major guidelines in a large, real-world p
Improving energy efficiency in agriculture is key to reducing environmental impact. Lighting in animal buildings is one of the most cost‐effective energy saving measures. Lighting retrofit offers a short payback period, enhances animal welfare and production, and aligns with regulations for phasing out fluorescent lighting. The purpose of this study was to investigate the energy-saving potential o
The feasibility of South Africa's just energy transition, as dictated by the speed of phasing out coal and scaling up renewables, will rest on a range of techno-economic, socio-political, and socio-technical factors. Interactions between these dimensions of the transition carry significant implications for energy justice. In response, this paper proposes the Just Transition Feasibility Framework (
The European Spallation Source is currently under construction in Lund, Sweden. Consisting of a linear accelerator delivering an unprecedented 5 MW proton beam to the spallation source, i.e. a rotating Tungsten disk, it will deliver high-flux neutron beams to multiple beamlines at which scientific experiments will be conducted in many scientific disciplines.To simulate the proton beam and for crea
Universities, operating at the intersection of state, market, and civil society, are increasingly called upon to address urgent global challenges, such as climate change, inequalities, and social injustice. This has given rise to hybrid roles for scholars, ranging from public intellectuals to policy advisers and academic entrepreneurs. Among these roles, scholar-activism stands out by explicitly a
We aimed to investigate the association between psychotropic drug use (proxy for psychological health) and Complex Regional Pain Syndrome (CRPS) type 1 and type 2 in upper and lower limbs. We also assessed the impact of demographic and socioeconomic factors. From a national record linkage database [4,706,821 individuals (25–64 years); CRPS type 1 = 809; type 2 = 225], prevalence ratios (PR), absol
Developing a robust decision analysis framework for selecting appropriate building envelope assemblies is essential to ensure moisture safety, energy efficiency, and sustainability. Recently, Bayat Pour et al. introduced the inutility decision analysis (IDA) method, which integrates moisture safety criteria with sustainability considerations, including economic and environmental aspects. This stud
Adaptive reuse, the conversion of buildings for new functions, is gaining prominence for its cost-saving and environmental benefits. However, prior research primarily focuses on preserving the building envelope, often overlooking building services such as ventilation, which affect occupant well-being, costs, and environmental performance. This study explores a novel adaptive reuse approach by reus
BACKGROUND: Monitoring of vital signs is essential in anaesthesia care and plays a key role in preventing adverse events. Technological innovation is recognised as an important factor in enhancing patient safety. Smart glasses represent a novel tool that may support anaesthesia professionals in monitoring vital signs; however, their practical use and user experiences in anaesthesia care remain ins
Tin modified sodium manganese hexacyanoferrate, as a Prussian blue analogue, is studied as a cathode material for sodium ion batteries. By co-precipitation of Sn4+ during the synthesis process, the modified sodium manganese hexacyanoferrate materials crystallize with face-centered cubic structure with space group Fm3¯m, while the unmodified one possesses a rhombohedral structure with space group R
(Graph Presented) In the search for new cathode materials for rechargeable lithium batteries, conversion-type materials have great potential because of their ability to achieve high specific capacities via the full utilization of transition metal oxidation states. Here, we report for the first time that copper phosphate can be used as a novel high-capacity cathode for rechargeable Li batteries, ca
Self-harm, including nonsuicidal self-injury and suicide attempts, is common among youth, associated with elevated psychopathology, suicide risk, and increased demand for clinical services. Despite advances in understanding and treatment, few interventions have demonstrated efficacy in randomized controlled trials (RCTs), which are considered the gold standard for evaluating treatment effects by r
Background: Sjögren’s disease (SjD) is an autoimmune condition affecting exocrine glands, resulting in decreased saliva and tear production. Aquaporin 5 (AQP5) is a transmembrane water channel playing a central role in water transport. In SjD, deregulation of AQP5 expression, trafficking and interactions with various proteins contribute to the underlying disease mechanisms. Methods: Co-immunopreci
Remission is emerging as a feasible treatment goal in moderate-to-severe asthma, driven by the success of biologic therapies in controlling inflammation and reducing exacerbations. Yet current definitions of remission—focused on symptom control, lung function, and corticosteroid reduction—lack precision, can only be ascertained retrospectively, and do not reflect the underlying mechanisms and path
Health-related quality of life (HRQoL) has been shown to predict overall survival (OS) in several different malignancies, but not in patients with small intestinal neuroendocrine tumours (siNET). We evaluated the influence of HRQoL on survival in patients with siNET. We included 85 patients with advanced siNET who completed the validated HRQoL instruments, EORTC QLQ-C30 and GI.NET21. We used Cox p
