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Utvärdering av ett målprotein för behandling av ledgångsreumatism Reumatisk artrit (RA), eller ledgångsreumatism som det också kallas, är en autoimmun sjukdom som 1% av världens befolkning lider av. Kroppens egna immunceller blir autoreaktiva och attackerar lederna i främst händer och fötter. Den ökade mängden immunceller i de här lederna resulterar i svullnad och inflammation, men även ben och bRheumatoid arthritis is an autoimmune disease resulting in swelling and destruction of bone and cartilage within the small joints. The mechanism behind the disease is not fully understood, but the interaction of autoreactive T-cells with effector cells like B-cells and macrophages through cytokine signaling is believed to be important. A potential target for drug development against arthritis that

Increasing awareness and change in attitudes towards environment has given rise to the sustainable development and this development has stimulated environmental innovations globally in the last years. The recent studies show that in near future there will be more packaging solutions from renewable resources. The purpose of this thesis is to investigate how a brand owner using renewable packaging m

This master thesis work consists of the development of new hardware and software for the control box of an azimuthal guidance system used by aircrafts during the approach to the runway. The thesis work was done at Safegate International AB as a project running along the usual development projects. When designing electronics to be used on an airfield there are a lot of regulations and standards t

Total resection of glioblastoma multiform (GBM), the most common and aggressive malignant brain tumor, continues to be a challenge. Achieving complete resection is limited by difficulty in intraoperative discrimination between normal and residual tumor cells. This project contributes to the development and evaluation of a fiber-optical based fluorescence/reflectance spectroscopy system as an intra

Investigation of a novel condition monitoring approach, combining artificial neural network (ANN) with a sequential analysis technique, has been reported in this paper. For this purpose operational data from a Siemens SGT600 gas turbine has been employed for the training of an ANN model. This ANN model is subsequently used for the prediction of performance parameters of the gas turbine. Simulated

Water vapor condensation and two-phase flow appear in plate heat exchangers being used as condensers. Analysis of water phase change and flow dynamics is an important but complicated task due to large change in water physical/transport properties across the water liquid-vapor interface boundary. In particular, a singular-link behaviour in Navier-Stokes (N-S) equations is present due to the large s

This note is about promoting singularity subtraction as a helpful tool in the discretization of singular integral operators on curved surfaces. Singular and nearly singular kernels are expanded in series whose terms are integrated on parametrically rectangular regions using high-order product integration, thereby reducing the need for spatial adaptivity and precomputed weights. A simple scheme is

The development of treatments based on cognitive models of worry has led to improved outcomes for adults with Generalized Anxiety Disorder (GAD), and holds out the promise that similar improvements may be achieved for GAD further down the age range. The aim of the current study was to evaluate the effect of a GAD specific,cognitive treatment in a sample of children and adolescents with GAD. Sixtee

Popular Abstract in Swedish Om flyttningens betydelse för utbredningsmönster för arktiska fåglar Sara Henningsson Fågelflyttning är en anmärkningsvärt framgångsrik strategi som möjliggör att en större mängd individer kan försörjas genom rörelser mellan olika regioner. Inom dessa olika områden, som ofta ligger mycket långt ifrån varandra, kan fåglarna utnyttja stora säsongsmässigt tillgängliga resFlexibility as well as constraints to the evolution of migration routes has the possibility of affecting large-scale patterns of geographical ranges of animals both by facilitating, but sometimes restricting, accessibility to and colonization of new regions. This dissertation concerns the broad-scale effects migration has on the distributional patterns of birds in the Arctic. I studied the circu