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Popular Abstract in Swedish Måndagen den 16:e april 2001 informerade det amerikanska företaget Cisco, med produkter och tjänster inom nätverk och datakommunikation, att de skulle skriva ned sitt komponentlager med 2,2 miljarder dollar. Detta skedde i samband med en globalt vikande efterfrågan och det som skulle komma att kallas IT-bubblan i folkmun. Investerare och företagsledning ställde sig frågThis dissertation presents a framework for describing, a process for identifying, and a model for evaluating misalignments in the supply chain when varying elements such as structure, processes, and management components. The developed approach makes it possible to address and improve the alignment of supply chain structures, processes, and management components. To further increase knowledge of h

Pyranose 2-oxidase (P20x) has several proposed biotechnological applications such as a bio-component in biofuel cells or for carbohydrate transformations. To improve some of the catalytic properties of P20x from Trametes multicolor, we selected a semi-rational approach of enzyme engineering, saturation mutagenesis of active-site residues and subsequent screening of mutant libraries for improved ac

Huntington's disease (HD) is a devastating, neurodegenerative condition, which lacks effective treatment. Normal Huntingtin (HTT) and mutant Huntingtin (mHTT) are expressed in multiple tissues and can alter transcription of microRNAs (miRs). Importantly, miRs are present in a bio-stable form in human peripheral blood plasma and have recently been shown to be useful biomarkers in other diseases. We

This paper presents a theoretically and methodologically grounded GIS-based model for the measurement and mapping of an index of living conditions in urban residential areas across Sweden. Further, the model is compared and evaluated using the Swedish Police’s assessment of crime-exposed areas. The results indicate that the geographically measured vulnerable living conditions overlap to a large ex

Humanitarian organizations transitioning from a service provider (SP) to a capacity strengthener (CS) in countries where there is political stability and economic growth presents a set of opportunities and challenges. Despite this there has been limited research studies that have been conducted on the transition of humanitarian organizations in this context. The overall objective of this research

https://www.cors.lu.se/formular/more-human-borderlands-disease - 2026-07-05

α-Synuclein is a presynaptic protein associated to Parkinson's disease, which is unstructured when free in the cytoplasm and adopts α helical conformation when bound to vesicles. After decades of intense studies, α-Synuclein physiology is still difficult to clear up due to its interaction with multiple partners and its involvement in a pletora of neuronal functions. Here, we looked at the remarkab

Originally published in two volumes in 1748-9, John Cleland’s Memoirs of a Woman of Pleasure (or Fanny Hill) has long been an underground classic. Because of this underground status, and the prejudicial treatment of literary pornography, Memoirs has never been thoroughly investigated. Above all, insufficient attention has been given to the educational and moral aspects of Cleland’s novel. Cleland’

A new and freely available model-based PID design tool for Matlab is introduced. It can be used to solve Maximal Integral Gain Optimization (MIGO) and (load) Integral Absolute Error (IAE) problems. Robustness is ensured through H-inf constraints on the closed-loop transfer functions. A Youla parameter (Q design) method for comparison with the optimal linear time-invariant (LTI) controller for the

We show, through a combination of density function theory-based molecular dynamics simulations (DFT-MD) and experimental X-ray absorption fine structure spectroscopy (XAFS) studies, that the iodate ion (IO 3 -) contains a local region that is strongly hydrated as a cation. The local region adjoining the I atom is sufficiently electropositive that thr

The purpose of this paper is to explore themes and challenges in developing environmentally sustainable logistical activities. The approach is explorative with a cross sectional design that takes advantage of ten case studies out of selected logistics service providers (LSPs) operating primarily in the Scandinavian countries. The findings illustrate the major themes by analyzing current and future

Observationally, the galactic chemical evolution of sulphur shows a complex pattern. Some studies find no correlation between [S/Fe] and [Fe/H] at halo metallcities, which is typical for alpha -elements, others find [S/Fe] increasing towards lower metallicities, and still others find a combination of the two. Each scenario has different implications for the Galactic chemical evolution of sulphur.

Apelin, a recently discovered peptide with wide tissue distribution, regulates feeding behavior, improves glucose utilization, and inhibits insulin secretion. We examined whether apelin is expressed in human islets, as well as in normal and type 2 diabetic (T2D) animal islets. Further, we studied islet apelin regulation and the effect of apelin on insulin secretion. Apelin expression and regulatio

The development towards total offers; integrated product and service offers, is a trend in industry, particularly in business to business relations. This strive towards more extended offers can be noticed in a wide range of companies from different branches, and it has important implications on management. Today there is no established method available to handle the extended risks associated with