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Inherited resistance to activated protein C (APC) was recently discovered to be a cause of familial thrombophilia and is now known to be the most common genetic risk factor for venous thrombosis. It is caused by a single point mutation in the gene for factor V, which predicts substitution or arginine (R) at position 506 with a glutamine (Q). Accordingly, the activated form of mutated factor V (FVa
CD40 is a tumour necrosis factor receptor (TNFR) family member of central importance for the adaptive immune system. To elucidate the functional role of the different extracellular domains of CD40, we have created a set of truncated CD40 molecules where domains, or parts of domains, have been removed. These CD40 proteins, which contain a peptide tag in the N-terminal end, have been expressed in a
Integration of machine learning (ML) components in critical applications introduces novel challenges for software certification and verification. New safety standards and technical guidelines are under development to support the safety of ML-based systems, e.g., ISO 21448 SOTIF for the automotive domain and the Assurance of Machine Learning for use in Autonomous Systems (AMLAS) framework. SOTIF an
Purpose Hodgkin lymphoma (HL) survivors are at an increased risk of stroke because of carotid artery irradiation. However, for early-stage HL involved node radiation therapy (INRT) reduces the volume of normal tissue exposed to high doses. Here, we evaluate 3-dimensional conformal radiation therapy (3D-CRT), volumetric-modulated arc therapy (VMAT), and proton therapy (PT) delivered as INRT along w
The emergence of the Faster-Than-Nyquist signaling (FTN) technology has im- proved the tight spectrum resources by compressing the transmission interval between adjacent pulses. In a natural environment, data transmission via a wire- less medium and through multi-path, at a high data rate, the leakage of these paths among symbols can cause severe inter-symbol interference (ISI). In order to compen
A concept for a bee, - and beekeeper friendly horizontal top bar beehive for northern climates, aiming to provide a platform for discussion and further development of bee keeping methods. An ergonomic alternative to the heavy handled traditionally used vertical hives, Apivaria aims to offer an older generation a possibility to postpone retirement from beekeeping, while introducing a new generation
Probing the solid/liquid interface of batteries operando/in situ with ambient pressure X-ray photoelectron spectroscopy (APXPS) using the dip-and-pull method remains a challenging endeavor due to spatial and temporal variations in liquid layer shape, thickness, and composition. Monitoring the electrochemical and topographical nature of the liquid edge where the interface is accessed is essential t
Many studies have tried to explain the stock market value premium identified by Fama and French and Rosenberg, Reid and Lanstein. To the proponents of conventional asset pricing theory the value premium, measured by HmL (high book-to-market minus low book-to-market), is a bit of a dilemma. This is due to that the value of growth stocks depend more on business cycles than on value stocks, whose val
Exploring new ways of studying communication and interactions in media and journalism is of high interest considering that we live in a constantly transforming media landscape. To build sustainable journalism and media organizations requires a holistic approach of the development involving audience, news producers and other stakeholders.This panel originates from studies applying action research o
The gene, acyl-CoA:diacylglycerol acyltransferase1 (DGAT1), was recently identified as the one underlying the quantitative trait locus (QTL) for milk production traits in the centromeric region of the bovine chromosome 14. Until now, 2 alleles, the lysine variant (increasing fat yield, fat and protein percentage) and the alanine variant (increasing protein and milk yield), were postulated at DGAT1
The purpose of this thesis is to develop knowledge about visual information seeking and how it might be affected by socio-technical circumstances, with its focus on GeoGuessr players’ research through Google Street View. The study asks two research questions: 1. How do GeoGuessr players use Google Street View to do research? and 2. How can Google Street View’s socio-technical circumstances affect
Predicting live birth after the first IVF/ICSI treatment is challenging, as many factors may interact to affect IVF/ICSI outcomes. Adenomyosis is one factor that impacts live birth rates. Machine learning algorithms have been shown valuable for detecting complex dependencies and predicting outcomes in different clinical settings. We aimed to develop a prediction model for live birth after IVF/ICSI
Bakgrund Fotledsstukningar är den vanligaste skadan inom basket och kan leda till bestående funktionsnedsättningar samt rädsla för återkommande skada. Syfte Syftet med studien var att undersöka funktionella skillnader mellan den skadade och den oskadade foten. Studien syftade även till att utvärdera självrapporterad funktion och rädsla för återgång till aktivitet bland basketspelare som drabbats a
