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Background: 4-1BB (CD137) is a co-stimulatory receptor highly expressed on tumor reactive effector T cells and NK cells, which upon stimulation prolongs persistence of tumor reactive effector T and NK cells within the tumor and induces long-lived memory T cells. 4-1BB agonistic antibodies have been shown to induce strong anti-tumor effects that synergize with immune checkpoint inhibitors. The firs

The immune processes associated with atherogenesis have received considerable attention during recent years. IgG FcRs (FcgammaR) are involved in activating the immune system and in maintaining peripheral tolerance. However, the role of the inhibitory IgG receptor FcgammaRIIB in atherosclerosis has not been defined. Bone marrow cells from FcgammaRIIB-deficient mice and C57BL/6 control mice were tra

Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m

Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody preparations may trigger effects ranging from enhanced pro-inflammatory activity to increased anti-inflammatory activity. In contrast, reduction of IgG gly

In a previous study we presented data indicating that the expanded population of CD4(-)CD8(-) (DN) alphabeta T cells in TCRalpha-chain-transgenic mice was partially if not entirely derived from gammadelta T cell lineage cells. The development of both gammadelta T cells and DN alphabeta T cells is poorly understood; therefore, we thought it would be important to identify the immediate precursors of

Measurements are presented of inclusive charm and beauty cross sections in e(+)p collisions at HERA for values of photon virtuality 12 <= Q(2) = 60 GeV2 and of the Bjorken scaling variable 0.0002 <= x <= 0.005. The fractions of events containing charm and beauty quarks are determined using a method based on the impact parameter, in the transverse plane, of tracks to the primary vertex, as measured

OBJECTIVE: To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. METHODS: A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>

Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E

Lokala och globala företag är starkt engagerade i att bidra till masterprogrammet och utbildningen erbjuder en helhetssyn på VR- och AR-teknik i världsklass i en tvärvetenskaplig forsknings- och lärandemiljö. Programmet utbildar kvalificerade yrkesverksamma som kan utforma, implementera, genomföra och utvärdera VR- och AR-applikationer samtidigt som etiska, kulturella och sociala konsekvenserna avRecent advances in computer graphics, sensors and screen technology give us unprecedented possibilities to completely immerse humans in virtual environments or augment real environments. VR/AR constitute a completely new computing paradigm finding its way into applications for industry, health care, education, entertainment etc. The Master’s Programme in Virtual Reality and Augmented Rea

Kursen behandlar: Direkta och iterativa lösningsmetoder för olika problem i lineär algebra, såsom lineära ekvationssystem, egenvärdesproblem och minsta-kvadratmetoden, Matris- och vektornormer, ortogonalisering, projektion, matrisfaktoriseringar, direkta och iterativa lösare, konditionstal, stabilitet hos en metod, komplexitet hos en algoritm, Tillämpning av ovanstående begrepp för att konThe course covers: Direct and/or iterative solution methods for various linear algebra problems such as linear systems of equations, eigenvalue problems and the least-squares method,  Matrix and vector norms, orthogonalisation, projection, matrix factorisations, direct and iterative solvers, condition numbers, stability of a method, complexity of an algorithm,  Applying these con

I denna kurs kommer du att utforska teoretiska och praktiska koncept avseende hållbar turism samt hur planering kan utföras i ett GIS. Du lär dig också praktiska och teoretiska övningar i hur ett känsligt naturområde kan kategoriseras i känslighet för turism, samt hur GIS kan användas för fältmätningar av turistpåverkan, samt för analys och visualisering. Dessutom undersöker vi hur ett förenklat bIn this course you will explore theoretical and practical concepts of sustainable tourism planning and how tourism can be planned using a GIS. Furthermore a simplified Tourism Decision Support System (TDSS) will be explored and how such a system can be linked to a GIS. This course includes practical and theoretical exercises regarding categorisation of sensitivity for land exposed to tourism and h

I den här kursen ska du skriva ett examensarbete, vilket kan vara ett arbete rörande en specifik problemställning eller forskningsfråga. Med hjälp av din tidigare kunskap och erfarenhet i ämnet statistik, tränas du i att självständigt behandla ett problemområde.   Utöver att skriva en uppsats kommer du att muntligt presentera arbetet vid ett seminarium, att närvara och deltaga i diskusIn this course you will write a thesis, which could consist of a specific problem or a research topic. Using your previoius skills and knowledge in Statistics, you will be trained in independently investigating a problem. Apart from writing a thesis you will orally present your work during a seminar, attend and participate in discussions during semiars, and act as an opponent during a pre