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Osteoarthritis is a chronic degenerative joint disease, and a rapidly growing cause of musculoskeletal disability, chronic pain, and reduced quality of life in an ageing European population. Our aims are to gain novel insights into osteoarthritis - its etiology, occurrence, natural history, treatments, prediction, disease monitoring, and disease burden - to allow for better care, decision making,

Anhedoni, minskad motivation att uppleva lust, är associerad med förändringar i belöningssystemet. Belägen i ventrala striatum utgör den bilaterala nucleus accumbens (NAcc) den centrala noden i detta nätverk, där dopamin agerar som huvudsaklig excitatorisk neurotransmitter. Studier med funktionell magnetresonanstomografi (fMRI) har visat att aktiviteten i ventrala striatum minskar under belöningsbAnhedonia, reduced motivation to experience pleasure, is associated with alterations in the circuitry of the reward system. Located in the ventral striatum, the bilateral nucleus accumbens (NAcc) is the central hub of this network where dopamine acts as the main excitatory neurotransmitter. Studies using functional magnetic resonance imaging (fMRI) found that activity in the ventral striatum is de

Artros, vår vanligaste ledsjukdom, orsakar smärta och funktionsnedsättning och drabbar främst knä, höft och fingerleder. Dagens behandling är fokuserad på smärtlindring, sjukgymnastik och eventuell ledersättning. Vid ledskada och artros bryts broskproteiner ner, och ledskador är en riskfaktor för artros, men mekanismerna som leder fram till artros är till stor del okända. Vi studerar de molekyläraOsteoarthritis (OA), the most common joint disease, causes pain and disability and mainly affects the knee, hip and finger joints. Treatment focuses on pain relief, physical therapy and eventually prosthesis. Cartilage proteins are degraded after joint injuries and in OA; joint trauma is a risk factor for OA, but the mechanisms leading to OA are mainly unknown. We study the molecular and structura

Streptococcus bovis/Streptococcus equinus complex (SBSEC) is a common cause of infective endocarditis (IE). For IE-pathogens, the capacity to activate and aggregate platelets is believed to be an important virulence mechanism. While the interactions between bacteria and platelets have been described in detail for many Gram-positive pathogens, little research has been carried out with SBSEC in this

As a major buyer of steel, the construction sector is uniquely positioned to advance the decarbonization of global steel through increasing the demand for green steel. To unlock this potential, deepened international collaborations on green public procurement, climate policies, and trade are needed.

Forskarna inom detta område arbetar med forskning om bruk, skadligt bruk och beroende av alkohol och andra droger, ofta ur ett socialvetenskapligt perspektiv. Även beroendeproblem kopplade till spel om pengar och dopning berörs. Forskningen rör såväl människors livsvillkor och erfarenheter som vårdens, socialtjänstens och andra samhällsaktörers arbete. Forskningen har en bred metodologisk ansats oResearchers in this area study the use, harmful use, and dependence on alcohol and other drugs, often from a social science perspective. Gambling-related addiction problems and doping are also included. The research addresses both people’s living conditions and experiences, and the work of healthcare services, social services, and other societal actors. It takes a broad methodological approach and

Introduction: Complicated perianal disease (cPD) may be the sole presentation of Crohn’s disease (CD). The role of small-bowel capsule endoscopy (SBCE) in the diagnostic algorithm of cPD is unclear. We aimed to evaluate the role of SBCE as a diagnostic tool, in patients with cPD, after a negative standard workup for CD. Methods: A multicenter, retrospective, cross-sectional study, in patients with